Phytochemical characterization and bioactivity of Lycium europaeum: A focus on antioxidant, antinociceptive, hepatoprotective and nephroprotective effects

Rjeibi, Ilhem; Feriani, Anouar; Saad, Ahmed S.; Ncib, Sana; Sdayria, Jazia; Saidi, Issam; Souid, Sami; Hfaïedh, Najla; Allagui, Mohamed Salah

doi:10.1016/j.biopha.2017.09.035

Cited by 22 publications

(13 citation statements)

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“…The scavenging activity of the antioxidant or the bleaching of the color stochiometrically depends on the number of electrons taken up (Shirwaikar, Patel, Kamariya, 2011). The present work also involved the evaluation of the antiradical activity of aqueous L. europaeum extract (IC 50 = 200 µg/mL) which was three fold higher than that obtained by Rjeibi et al (2017) with IC 50 = 65.87 µg/mL. It was observed that despite the inability of L. europaeum leaf extract to compete with the positive control BHT in scavenging DPPH (IC 50 = 24 µg/mL), this extract did possess mild antioxidant activity and may be considered as a potential preservative for medical applications.…”

Section: Discussionmentioning

confidence: 82%

“…Results showed that the total polyphenol and flavonoid amounts that could be extracted from L. europaeum leaves were 9.31 mg GAE/g DW and 6.01 mg CE/g DW, respectively. Rjeibi et al (2017) showed higher content of polyphenols (15.70 mg GAE DW) and flavonoids (7.64 mg CE/g DW) in the aqueous leaf extract of L. europaeum. Dahech et al (2013) showed that polyphenol and flavonoid contents of L. shawii fruit ranged from 75 to 377 mg GAE/g DW and from 2 to 11.60 mg CE/g DW, respectively.…”

Section: Discussionmentioning

confidence: 91%

“…Therefore, the potent antioxidant activity of L. europaeum leaves might be related to the presence of secondary metabolites such as polyphenols and flavonoids. In this way, Rjeibi et al (2017) reported that the chemical composition of L. europaeum leaf extract was rich in phenolic acids, namely caffeic (140.18 µg/g), gallic (117.17 µg/g), vanillic (26.54 µg/g) and coumaric (1.38 µg/g) acids, and flavonoids, namely naringenin (57.18 µg/g), epicatechin (33.14 µg/g), rutin (25.16 µg/g), kaempferol (12.33 µg/g), .0 a 590.6±112.5 d Data are expressed as mean± SD of measurements from 6 rats. Groups are labeled as follows: Group NC: normal control, Group DC: diabetic control, Group CLE: normal control fed with Lycium europaeum extract, Group DLE: diabetic rats fed with Lycium europaeum extract.…”

Section: Discussionmentioning

confidence: 95%

“…As reported by Akah, Uzodinma and Okolo (2011), the regeneration of islet β-cells after destruction by alloxan may be the primary recovery mechanism of alloxan-injected rats following plant extract administration. In addition, L. europaeum leaf extract was characterized by the presence of wellknown antioxidant phytochemicals, namely phenolic acids (caffeic, gallic, vanillic and coumaric acids) and flavonoids (naringenin, epicatechin, rutin, kaempferol, catechin, luteolin, apigenin and quercetin) as mentioned by Rjeibi et al (2017). Several studies have mentioned the antidiabetic effect of caffeic acid (Jung et al, 2006), gallic acid (Adeniyi et al, 2015), coumaric acid (Amalan et al, 2016), naringenin (Ortiz-Andrade et al, 2008), catechin (Liu et al, 2014), rutin (Ghorbani, 2017), kaempferol (Al-Numair et al, 2015), luteolin (Zang, Igarashi, Li, 2016), apigenin (Cazarolli et al, 2012) and quercetin (Vessal, Hemmati, Vasei, 2003).…”

Section: Discussionmentioning

confidence: 99%

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Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects

Tej

Hamdi

Beji

et al. 2019

Braz. J. Pharm. Sci.

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The purpose of the present investigation is to assess, for the first time, the antidiabetic, antihyperlipidemic and antioxidant activities of Lycium europaeum extract in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (120 mg/kg). Lycium europaeum aqueous extract was orally administered at a dose of 20 mg/kg for 28 consecutive days. Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were assayed at the end of the experimental period in all investigated groups. Antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were sought in the serum and pancreas. Lycium europaeum extract significantly increased HDL-C and reduced blood glucose, TC, LDL-C and TG as compared to the alloxan-control group. Lycium europaeum extract was also efficient in reducing oxidative stress in diabetic rats by increasing SOD, CAT and GPx activities both in the pancreas and the plasma of the animals. Moreover, Lycium europaeum extract contained considerable levels of polyphenols and flavonoids. It also exhibited an important antioxidant capacity and a remarkable ability to quench DPPH radicals and reduce irons. The obtained results highlight potentially relevant health beneficial effects of Lycium europaeum extract, reversing hyperglycemic, hyperlipidemic and oxidative stress effects in rats with alloxan-induced diabetes. Therefore, it may be considered as a promising alternative or complementary agent to diabetes treatment.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects

Tej

Hamdi

Beji

et al. 2019

Braz. J. Pharm. Sci.

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“…The quantity of proof reveals that customized cell demise, together with apoptosis of hepatic cells, is a vital explanation behind CCl 4 -incited hepatotoxicity. 60 Apoptosis is directed by a succession of modifiable proteins. The Bcl-2 relatives of proteins are principle apoptosis controllers.…”

Section: Discussionmentioning

confidence: 99%

Combination of metformin and luteolin synergistically protects carbon tetrachloride‐induced hepatotoxicity: Mechanism involves antioxidant, anti‐inflammatory, antiapoptotic, and Nrf2/HO‐1 signaling pathway

Yang¹,

Yang²,

Jiangmei³

2019

BioFactors

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Liver diseases are one of the fatal disorders due to the vital role of the liver. Carbon tetrachloride (CCl4) is the most perceived chemical substance utilized in developing models of hepatic damage. Metformin (Met) is a potent antidiabetic and redox modulatory agent that has shown anticancer and protective effects on various organs. Therefore, addition of therapy with natural antioxidative agents or herbal extracts shows defensive impacts against different injuries inside the body. Luteolin (Lut) can be found in several customary Chinese remedies. It has been reported for various pharmacological actions such as antitumor, antioxidative, and anti‐inflammatory impacts. Here, the liver injury rat model was established using CCl4 (1.00 mL/kg body weight) in vivo. The protective roles of Met and Lut separately or in combination were observed in hepatotoxicity induced by CCl4. The result was shown that both Met and Lut, while individually used, were normally active in diminishing CCl4‐caused hepatotoxicity. The combination of two drugs performed synergistically to improve liver damage caused by CCl4, as shown by the considerably improved liver dysfunction. Met and Lut showed highly antioxidative effects on CCl4‐treated rats moderately by increasing the activities and expression of the antioxidant enzymes. Along with this, a combination of Met and Lut significantly suppressed inflammatory responses, which is evidenced by the reduced level of inflammatory cytokines together with interleukin 1 beta (IL‐1β), tumor necrosis factor alpha (TNF‐α), and interleukin 6 (IL‐6). Additionally, CCl4‐agitated apoptosis was intensely reduced by Met and Lut through reducing cleaved caspase‐3 and Bax (pro‐apoptotic factor) while increasing Bcl‐2 (antiapoptotic factor) signaling pathways. Cotreatments of Met and Lut upregulated nuclear factor erythroid 2‐related factor 2 (NRF2) and heme oxygenase‐1 (HO‐1) expression in the CCl4‐intoxicated rat's liver. The above result recommended that combination of Met and Lut may have a substantial potential and synergizing impact against CCl4‐induced hepatotoxicity.

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Nephroprotective role and antioxidant capacity of Atriplex halimus on carbon tetrachloride-induced kidney damage in rats

et al. 2021

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Phytochemical characterization and bioactivity of Lycium europaeum: A focus on antioxidant, antinociceptive, hepatoprotective and nephroprotective effects

Cited by 22 publications

References 56 publications

Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects

Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects

Combination of metformin and luteolin synergistically protects carbon tetrachloride‐induced hepatotoxicity: Mechanism involves antioxidant, anti‐inflammatory, antiapoptotic, and Nrf2/HO‐1 signaling pathway

Nephroprotective role and antioxidant capacity of Atriplex halimus on carbon tetrachloride-induced kidney damage in rats

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