Nephroprotective role and antioxidant capacity of Atriplex halimus on carbon tetrachloride-induced kidney damage in rats

Slama, Kheira; Rouag, Meriem; Tichati, Lazhari; Taibi, Faiza; Boumendjel, Mahieddine; Boumendjel, Amel; Messarah, Mahfoud

doi:10.1007/s00580-021-03195-3

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Verbascoside, contained in the extract, favourably affected renal function and had a clear protective effect in conditions of intoxication [38]. Others investigated the nephroprotective effect of plant-derived extracts in the CCl 4 model of kidney damage [39,40]. One of the main criteria for the degree of kidney damage, are the histological changes in the renal parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Hepatoprotective Activity of an Extract from the Overground Parts of Phlomis russeliana Lag. ex Benth

Kondeva-Burdina,

Shkondrov,

Popov

et al. 2024

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An evaluation of the possible hepatotoxicity/hepatoprotective effects of a defatted extract of the above ground parts of Phlomis russeliana was conducted in vitro and in vivo. The extract was tested in vitro on hepatocytes alone and in a carbon tetrachloride (CCl4)-bioactivation model. The same toxic substance was used for the in vivo evaluation on old Wistar rats. The extract was standardised via high performance liquid chromatography (HPLC) by the quantification of total flavonoids and verbascoside. Gallic acid equivalents were used to express the content of total phenolic compounds. The identification of flavonoids in this species was undertaken for the first time. The extract was not statistically hepatotoxic in vitro on the isolated rat hepatocytes. In the CCl4-induced hepatotoxicity model, the extract had a hepatoprotective effect, which was concentration-dependant (the highest at 50 µg/mL). An in vivo study on old rats confirmed the observed antioxidant and hepatoprotective effects. The histological findings were favourable for the rats, given the extract and CCl4 in combination. They had an unchanged organ structure, which is commensurable with these animals, treated with a combination of CCl4 and silymarin.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and Hepatoprotective Activity of an Extract from the Overground Parts of Phlomis russeliana Lag. ex Benth

Kondeva-Burdina,

Shkondrov,

Popov

et al. 2024

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“…The kidney is the most crucial excretory organ, where all toxic metabolites are eliminated via urine. The toxic impact of CCL 4 on kidney function is mainly accredited to the OS caused by a high level of reactive oxygen species generation [28]. Both the liver and kidney are involved in CCL 4 metabolic pathway.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Olive Oil In Amelioration of Nephrotoxicity In Experimental Male Rats

Madany,

El-Zeftawy,

Sanosi

et al. 2023

New Valley Veterinary Journal

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The kidney is an essential part of the urinary system responsible for hormone secretion and blood filtration from waste products. Nephrotoxicity (NEP) is one of the most popular kidney diseases and originates from environmental toxic agents and a wide spectrum of therapeutic drugs. Olive oil (OO) is among the natural oils extracted from olives. It offers many health benefits against chronic diseases and has an immunostimulant role. The study was designed to predict the reno-protective impact of OO opposing NEP. The research model was performed using three groups of adult male albino rats (n=30); the control group, NEP induced group by carbon tetrachloride, and the third group protected against NEP by OO. Kidney function was evaluated by measuring serum urea, creatinine, uric acid, and electrolytes. Further, the oxidative stress parameters, thiobarbituric acid reactive substances, nitric oxide, and reduced glutathione were analyzed in renal tissue homogenate. In addition, the ELISA technique assessed both tumor necrosis factor-alpha and interleukin-6. The histopathological study of renal tissue was also inspected. The results demonstrated that OO has an excellent protective effect, such as greatly restoring the higher level of kidney parameters and oxidative stress injury. Further, OO declined the induced inflammation and fibrosis in the protective group compared to NEP. Therefore, due to OO promising nephroprotective potentiality, it could be used to avoid disorders linked to oxidative stress. It is strongly recommended to conduct further research on its application.

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“…The province (department) of El-Tarf (North East of Algeria) runs along the Mediterranean over 90km. This coastline teems with wild medicinal and aromatic plants (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). This harmonious greenery contains ecosystem variables and maintains the ecological stability of the region, which led to several inventories and researches on the vegetation of this region like the works of (16) as well as (17).…”

Section: Introductionmentioning

confidence: 99%

Insecticidal effect of Eucalyptus globulus and Rosmarinus officinalis essential oils on a stored food pest Ephestia kuehniella (Lepidoptera, Pyralidea)

Rekioua¹,

Boumendjel²,

Taibi³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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For the purpose of evaluating the local heritage of eastern Numidia, an ethnobotanical survey was conducted on a population located in the province (department) of El-Tarf (North-East of Algeria) on a frequency of use of two plants known in traditional health; Eucalyptus globulus (Myrtaceae) and Rosmarinus officinalis (Lamiaceae). After processing data, our results show a female dominance when using these plants on a fairly advanced age group (40 to 60 years old). These plants are used by the people at their fresh state and deem the leaf as the most used part for therapeutic and cosmetic purposes. Furthermore, steam baths and infusion remain the most widespread preparation methods. Most consumers use these plants to treat influenza, respiratory illnesses as well as diseases of the digestive tract. GC-MS of essential oils extracted from the plants studied disclose a dominance of the alcohols portrayed by the monoterpenes (42.73%), sesquiterpenes (32.6%) and oxides (10.48%) in E. globulus. Data also indicate a high content of oxides (38.11%) monoterpene alcohols (20.43%) and monoterpenes (19.70%) in R.officinalis. Toxicological contact tests were achieved on a store-products pest Ephestia kuehniella. The test results were assessed with E.globulus (LC50=0.013; LC95=0.081 µl/cm 2 ) and R.officinalis (LC50=0.011; LC95=0.059 µl/cm 2 ). The lethal time changes according to the dose used and the tested plant. In E.globulus, we observe (concentration: 0.005 µl/cm 2 ; LT50=56.2 h), (Concentration: 0.01 µl/cm 2 ; LT50=49.53h) and (Concentration: 0.04µl/cm 2 ; LT50=20.93h). Whereas in R.officinalis, we recorded (Concentration: 0.005 µl/cm 2 ; LT50=55.7h), (Concentration: 0.01µl/cm 2; LT50=54.99 h) and (Concentration: 0.04µl/cm 2 ; LT50=29.13 h). The bioinsecticide has also been administered by fumigation and underpins toxicity by the reduction of adults longevity in E.kuehniella with R.officinalis (LC50=4.03 µl/l air; LC95=14.73 µl/l air) and E.globulus (LC50=7.76 µl/lair; LC95=21.23 µl/l air). In addition, the tested plants show an outstanding repellent effect as long as E.globulus and R.officinalis essential oils respectively demonstrate a slightly repellent power at 42.22% (RD50=0.09 µl/cm 2 ; RD95=0.24 µl/cm 2 ) and repellent at 60.00% (RD50=0.06 µl/cm 2 ; RD95= 0.35 µl/cm 2 ) towards E.kuehniella adults. The plant resources represent a genuine reserve of bioactive molecules, which can create solutions to sustainable development issues. These plants might be the source of new molecules of combat against some pests in order to protect human health and safeguard the environment.

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Nephroprotective role and antioxidant capacity of Atriplex halimus on carbon tetrachloride-induced kidney damage in rats

Cited by 3 publications

References 41 publications

Antioxidant and Hepatoprotective Activity of an Extract from the Overground Parts of Phlomis russeliana Lag. ex Benth

Antioxidant and Hepatoprotective Activity of an Extract from the Overground Parts of Phlomis russeliana Lag. ex Benth

Efficacy of Olive Oil In Amelioration of Nephrotoxicity In Experimental Male Rats

Insecticidal effect of Eucalyptus globulus and Rosmarinus officinalis essential oils on a stored food pest Ephestia kuehniella (Lepidoptera, Pyralidea)

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