Phytochemical and Toxicity Evaluation of Traditional Herb: Lagerstroemia speciosa L. (Banaba) by MCF-7 Cell Line and Brine Shrimp Lethality Bioassay

Abstract

The main objective of this study was to determine the cytotoxicity of crude extract of the leaves of Lagerstroemia speciosa (Banaba). In vitro MCF-7 cell line and in vivo brine shrimp lethality bioassay methods were followed to investigate the cytotoxicity of the selected sample. In this study, the qualitative phytochemical assessment demonstrated the presence of alkaloids, carbohydrate, glycosides, saponins, terpenes, steroids, phenols and flavonoids in Banaba extract. Moreover, the present findings revealed the non-cytotoxic nature of L. speciosa leaves extract on both MTT-assay and brine shrimp lethality bioassay.
 Bangladesh Pharmaceutical Journal 22(1): 45-49, 2019

Lagerstroemia Speciosa (L.) Pers Leaf Extract Attenuates Lung Tumorigenesis via Alleviating Oxidative Stress, Inflammation and Apoptosis

“…The cytotoxic effects of LLE against A549 lung cancer cells caused significant decrease in cell viability in a concentration-dependent manner. Leaves of the L. speciosa plant are rich in polyphenolic compounds [12,45]. Anantharaju et al [46] reported the cytotoxic effects of phenolic compounds against various cell lines.…”

Green Synthesis, Characterization and Antimicrobial activity of Silver Nanoparticles from the Extract of Lagerstroemia speciosa

“…The secondary metabolites quantified in this analysis have a great deal of biological effects and pharmacological properties 49 . These prelims phytochemicals have been observed from the different parts (fruits, leaves and roots) of L. speciosa [53][54][55] . Therefore, the carbohydrates, phenols, proteins, saponins and tannins present in Ee-Ls are the most effective biomolecule in synthesis of Ls-Ag NPs 50,51 .…”

Lagerstroemia speciosa (L.) Pers. triggers oxidative stress mediated apoptosis via intrinsic mitochondrial pathway in HepG2 cells

“…These phyto-compounds are established independently as cytotoxic agents against a variety of cancer cell lines including HepG2 cells. 14,[28][29][30] Recently, studies have explored the cytotoxic potentials of ethanolic and methanolic banaba leaves extract against breast cancer cell lines. 31,32 Therefore, it is suggested that regardless of the cell line, EBLE induced cytotoxicity in HepG2 cells, and this could be due to the presence of above phytoconstituents.…”

“…The present study revealed the presence of active phytocompounds like berberine, and gallic acid in EBLE. These phyto‐compounds are established independently as cytotoxic agents against a variety of cancer cell lines including HepG2 cells 14,28‐30 . Recently, studies have explored the cytotoxic potentials of ethanolic and methanolic banaba leaves extract against breast cancer cell lines 31,32 .…”