Phytochemical and Therapeutic Potential ofCitrus grandis(L.) Osbeck: A Review

Abstract

Citrus grandis or Citrus maxima, widely recognized as Pomelo is widely cultivated in many countries because of their large amounts of functional, nutraceutical and biological activities. In traditional medicine, various parts of this plant including leaf, pulp and peel are used for generations as they are scientifically proven to have therapeutic potentials and safe for human use. The main objective of this study was to review the different therapeutic applications of Citrus grandis and the phytochemicals associated with its medicinal values. In this article different pharmacological properties like antimicrobial, antitumor, antioxidant, anti-inflammatory, anticancer, antiepileptic, stomach tonic, cardiac stimulant, cytotoxic, hepatoprotective, nephroprotective, and anti-diabetic activities of the plant are highlighted. The enrichment of the fruit with flavonoids, polyphenols, coumarins, limonoids, acridone alkaloids, essential oils and vitamins mainly helps in exhibiting the pharmacological activities within the body. The vitamins enriched fruit is rich in nutritional value and also has minerals like calcium, phosphorous, sodium and potassium, which helps in maintaining the proper health and growth of the bones as well as the electrolyte balance of the body. To conclude, various potential therapeutic effects of Citrus grandis have been demonstrated in recent literature. Further studies on various parts of fruit, including pulp, peel, leaf, seed and it essential oil could unveil additional pharmacological activities which can be beneficial to the mankind.

Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits

“…Antioxidants play an important role in the promotion of cardiovascular health since oxidative stress that inflicts the myocardium can be associated with the incidence of atherosclerosis, which increases the risk of coronary artery disease [ 100 , 101 ]. C. sativum has been demonstrated in many studies to possess a pronounced antioxidant activity, and this is mainly due to the activity of polyphenols, vitamins, and sterol constituents of coriander [ 78 , 89 , 90 ].…”

Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review

“…Citrus grandis (L.) Osbeck, commonly known as Pomelo, belongs to the family Rutaceae and is considered the significant ancestor of the grapefruit (Anmol et al, 2021). Red wendun is the local name for C. grandis in Taiwan.…”

Supercritical CO2 assisted extraction of essential oil and naringin from Citrus grandis peel: in vitro antimicrobial activity and docking study

“…C. grandis fruits are not only served as food but are also considered as a traditional medicine around the world. 1 Although the peel of C. grandis fruits mainly contains flavonoids and essential oils that possess beneficial bioactivities for human health, it is considered to be agricultural waste. 2 Thus, the utilization of the C. grandis peel for the manufacture of natural products is an interesting topic that is related to pharmaceutical and environmental industries.…”