Background: Wound-healing in the skin is one mechanism that maintains homeostasis. Ineffective skin wound healing is a significant health problem that ultimately causes morbidity and mortality. The process of wound healing using traditional medicine has a good effect with various mechanisms of action. This review aims to provide insights related to the wound-healing mechanisms of several plants in HaCat cells. Methods: The literature study method was used from primary and secondary libraries. The library search was conducted using online-based library search instruments from 1988 to 2021, such as NCBI-PubMed, Google Scholar, and Elsevier. Results: The wound-healing mechanism includes processes that restore skin integrity through four stages: hemostasis, inflammation, multiplication, and remodeling. Many plants have been studied to have activity in wound healing by various mechanisms. Conclusions: Several compounds in plants have shown the activity in wound healing in keratinocyte cells  by various mechanisms.

Background: The skin is the largest organ of the human body, around 15% of the body weight consisting of the epidermis, dermis, and subcutaneous. The skin's primary function is to protect our body from external factors that can harm the body by forming a protective barrier that covers the body. This review aims to provide insights related to wound-healing mechanisms of several plants in HaCat cells. Methods: The literature study method used, both from primary and secondary libraries. The library search was conducted using online-based library search instruments from 2009 to 2021, such as NCBI-PubMed and Google Scholar. Results: The wound-healing mechanism includes processes that restore skin integrity through four stages: hemostasis, inflammation, multiplication, and remodeling. Many plants have been studied to have activity in wound-healing by various mechanisms. Conclusions: Therefore, it is essential to research wound-healing mechanisms to find treatments sourced from natural compounds.

Melanoma skin cancer is a malignant melanocyte tumor considered the most invasive and dangerous skin cancer, with an average five-year survival rate of less than 5% after metastasis. Thus, a new strategy for preventing and treating cancer from the natural product is required. Medicinal plants are the potential as an alternative against cancer. This review article aims to determine natural products from medicinal plants which have the potential as an anticancer in melanoma skin cancer in vitro and in vivo. 40 plants have been selected based on the selection criteria for anticancer compounds. In vitro studies showed that the plant can reduce cell viability through cell cycle inhibition and apoptosis induction and inhibit angiogenesis, invasion, and metastasis in human melanoma skin cancer. Therefore, further research is required to explore more plants, especially medicinal plants, their active compounds, and the mechanism of anticancer action to be used as standard herbal medicines.

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