Phytochemical and pharmacological study of Ficus palmata growing in Saudi Arabia

Abstract

Phytochemical study of the aerial parts of Ficus palmata utilizing liquid-liquid fractionation and different chromatographic techniques resulted in the isolation of a new isomer of psoralenoside namely, trans-psoralenoside (5) in addition to, one triterpene: germanicol acetate (1), two furanocoumarins: psoralene (2), bergapten (3), one aromatic acid vanillic acid (4) and the flavone glycoside rutin (6). Structures of the isolated compounds were established through physical, 1D- and 2D-NMR and MS data. The total extract and fractions of the plant were examined in vivo for its possible effects as hepatoprotective, nephroprotective, antiulcer and anticoagulant activities in comparison with standard drugs. Hepatoprotective activity was assessed via serum biochemical parameters including aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP) and total bilirubin. Tissue parameters such as non-protein sulfhydryl groups (NP-SH), malonaldehyde (MDA) and total protein (TP) were also measured. In addition to tissue parameters, nephroprotective effect was evaluated by measuring the serum levels of sodium, potassium, creatinine and urea. Histopathological study for both liver and kidney cells was also conducted. Antiulcer activity was explored by observing stomach lesions after treatment with ethanol. Whole blood clotting time (CT) was taken as a measure for the anticoagulant activity of the extract. Antioxidant activity of the total extract and fractions of the plant was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and ascorbic acid as standard.

Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats

“…Additional putative mechanisms that may contribute to the protective effects of DPP treatment include its previously reported anti-inflammatory potential [27], as APAP toxicity triggers an inflammatory response in the hepatic tissue [58]. Compelling evidence suggests that bioactive constituents of DPP possess anti-inflammatory activities in animal models [59][60][61][62]. It is, therefore, tempting to speculate that anti-inflammatory effect of DPP and its constituents [63] further attenuate APAP triggered hepatorenal damage.…”

Investigating hybridization and variability between Ficus species in Saudi Arabia through DNA barcoding approach and morphological characters

“…caprificus (caprifig or wild type) (Edmond et al, 1975;Weiblen, 2000). Fig fruits have mild laxative activity (Baraket et al, 2009) and their extracts are widely used to treat several diseases such as inflammation, jaundice , epilepsy, influenza, whooping cough, bronchitis, tonsillitis, enteritis, bruises, toothache and bacillary dysentery (Alqasoumi et al, 2014).…”

Isolation and Identification of <i>Ficus Palmata</i> Leaves and Their Antimicrobial Activities

“…The air dried fruits ground to moderately fine powder and soxhlet extracted with petroleum ether, chloroform, ethyl acetate, acetone, methanolic, ethanolic and water using soxhlet apparatus [7]. Each extract was evaporated to dryness under reduce pressure using rotary evaporator.…”

“…It is mostly consumed as fresh fruit in local markets but may also be dried, jam, jelly, squash, dry vegetable, pickled, and processed into marmalade, and fruits of Bedu are well known as traditional medicines in Uttarakhand and have been used for many years for the treatment of stomach ulcers, digestive system complaints [2], bronchitis, eczemas, haemorrhoids, and as a diuretic agent, among others [3]. Ficus palmata is employed frequently in the traditional medicine as gastrointestinal, hypoglycemic, insulinase, anti-tumour, anti-ulcer [4], antidiabetic, lipid lowering, Anti-calcinogenic activity [5], antifungal activities and antiinflammatory [6]. Although there are many studies on Bedu, the functional compound and antimicrobial activity of leave of Ficus palmata (Fig.…”