Phytochemical and pharmacological studies on Mikania micrantha H.B.K. (Asteraceae)

Pérez-Amador, MC; Ocotero, Verónica Muñoz; Balcazar, R Ibarra; Jiménez, Federico García

doi:10.32604/phyton.2010.79.077

Cited by 11 publications

(10 citation statements)

References 9 publications

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“…The hexane extract of stems and leaves of M. micrantha showed more potent anti‐inflammatory effect than the ethyl acetate extracts of seeds and inflorescence extracts. The hexane extract from stems and leaves showed 49.69 % inhibition of inflammation of the mouse ear edema (2.5 g/ear) in comparison to the seed and inflorescence extracts (51.75 % inhibition) [38] …”

Section: Traditional Usesmentioning

confidence: 92%

“…Staphylococcus aureus and beta haemolytic Streptococcus group A, two common pathogens, were found to be sensitive at a disk concentration of 100 g. [24] The ethyl acetate extracts of M. micrantha exhibited the highest antibacterial effect on Escherichia coli and Bacillus subtilis among the methanol, hexane and ethyl acetate extracts of leaves and stems, and seeds and inflorescences. [38] Six compounds (deoxymikanolide, dihydroscandenolide, scandenolide, mikanolide, m-methoxybenzoic acid and dihydromikanolide) were isolated from the M. micrantha chloroform leaf extract and their antibacterial potential were evaluated against pathogenic bacteria. Among the compounds, deoxymikanolide, a sesquiterpene lactone, showed the best antibacterial effect.…”

Section: Anti-bacterial Effectsmentioning

confidence: 99%

“…The hexane extract from stems and leaves showed 49.69 % inhibition of inflammation of the mouse ear edema (2.5 g/ear) in comparison to the seed and inflorescence extracts (51.75 % inhibition). [38] The in-vitro anti-inflammatory assays were performed by assessing their proficiency to impede hypotonic solution and heat-mediated hemolysis of human red blood cells and found that the M. micrantha ethanol extract demonstrated a dosedependent anti-inflammatory effect and the level of protection increased with the elevation of dose of the samples. [18] In a recent investigation, the ethyl acetate extracts of flowers and leaves of M. micrantha exhibited cyclooxygenase, nitric oxide synthase, lipoxygenase, protease, and myeloperoxidase inhibition in vitro and was found to inhibit multiple pathways of inflammation and act as an efficacious plant-based antiinflammatory drug.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Ali Khan,

El‐Kersh,

Islam

et al. 2023

Chemistry & Biodiversity

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Mikania micrantha is utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches of skin, chicken pox, healing of sores and wounds, colds and fever, nausea, jaundice, rheumatism, and respiratory ailments. This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti‐inflammatory, anti‐microbial, anti‐dermatophytic, anti‐protozoal, anthelmintic, cytotoxic, anxiolytic, anti‐diabetic, lipid‐lowering and antidiabetic, spasmolytic, memory‐enhancing, wound‐healing, anti‐aging, and thrombolytic activities. No clinical studies have been reported to date. M. micrantha might be one of the potential sources of phytotherapeutic compounds against diverse ailments in humans. Studies are required to confirm its safety profile in experimental animals prior to initiating clinical trials. Moreover, adequate investigation is also crucial to clarify exact mechanism of action for each biological effect.

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Section: Traditional Usesmentioning

confidence: 92%

Section: Anti-bacterial Effectsmentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

See 1 more Smart Citation

Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Ali Khan,

El‐Kersh,

Islam

et al. 2023

Chemistry & Biodiversity

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“…The antitumor activity of M. micrantha and its ability to inhibit the growth of cancer cell lines have previously been reported [11,12]. M. micrantha is also supposed to have antifungal, antibacterial [13,14], and anti-in ammatory properties [15]. A. houstonianum has been examined for antimicrobial, mosquitocidal, and other types of bioactivity [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…Kurade et al [16] and Zeeshan et al[55] previously identi ed the presence of volatile organic compounds (VOCs) in A. huostonianum, whileIshak et al [56] and Perez-Amador et al[15] identi ed the presence of volatile compounds in M. Micrantha extracts. In the present study, we identi ed volatile compounds in these two plant species growing at two different altitudes.…”

mentioning

confidence: 99%

Determination of UPLC-ESI MS/MS- and GC-MS-based altitudinal variations in the bioactive potential of traditional medicinal plants

Singh,

Passari,

Kumar

et al. 2024

Preprint

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Traditional medicinal plants have attracted scientific interest due to their bioactive compounds, and the levels of their constituents vary with location and altitude. The present study was designed to evaluate the pharmacological potential of two traditional medicinal plants, Mikania micrantha and Ageratum huostonianum; these were collected from two sites, Murlen National Park (MNP) and Dampa Tiger Reserve (DTR), which are located at different altitudes. Both plant species are used by local traditional healers in Mizoram, Northeast India, for the treatment of various health problems. We hypothesized that altitudinal variation would affect these plants' chemical composition and bioactive potential. Plant extracts were evaluated for antioxidant, antimicrobial, and cytotoxic activities. The results show that the plants located at a higher altitude, i.e., MNP, showed higher TPC (615.7 ± 0.58 and 453.80 ± 0.95 µg gallic acid equivalents/mg of plant extract dry weight (µg GAE/mg) for M. micrantha and A. huostonium, respectively) and TFC (135.4 ± 0.46 and 120.66 ± 1.93 µg quercetin equivalents/mg of plant extract dry weight (µg GE/mg) for M. micrantha and A. huostonium, respectively). The extract of A. houstonianum (MNP) exhibited significantly greater antioxidant activity against ABTS radicals (IC50 241.6 µg/mL) as compared to the extract of A. houstonianum (DTR) (IC50 371.2 µg/mL). The composition of the bioactive compounds present in the plants was determined using UPLC-ESI MS/MS and GC/MS, which detected five and ten compounds in the A. houstonianum and M. micrantha extracts, respectively. Plant species collected from the Murlen National Park site had high bioactivity potential and contained several bioactive compounds. A distinct variation between the volatile and non-volatile compounds was revealed. The collective data in this study show the influence of altitude on the biological compound production of selected medicinal plants. The findings will be utilized in determining the plant material needed for the development of bioactive formulations.

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Preparation and characterization of mikania micrantha (MM)/chitosan (CS) nanocomposites with polyvinyl alcohol (PVA) back layer

Uddin

Mohebbullah

Islam

et al. 2023

J Sol-Gel Sci Technol

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Phytochemical and pharmacological studies on Mikania micrantha H.B.K. (Asteraceae)

Cited by 11 publications

References 9 publications

Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Determination of UPLC-ESI MS/MS- and GC-MS-based altitudinal variations in the bioactive potential of traditional medicinal plants

Preparation and characterization of mikania micrantha (MM)/chitosan (CS) nanocomposites with polyvinyl alcohol (PVA) back layer

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