<i>Mikania micrantha</i> Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Ali Khan, Muahmmad; El‐Kersh, Dina M.; Islam, Md. Shafiqul; Ara Khan, Shams; Kamli, Hossam; Sarkar, Chandan; Bhuia, Md. Shimul; Islam, Tawhida; Chandra Shill, Manik; Gobe, Glenda C.; Sönmez Gürer, Eda; Setzer, William N.; Sharifi‐Rad, Javad; Torequl Islam, Muhammad

doi:10.1002/cbdv.202300392

Cited by 5 publications

(1 citation statement)

References 93 publications

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“…Medicinal plants have been an essential source of human therapeutic preparations for both curative and preventive purposes. They have also been utilized to extract significant bioactive components [42,43] . Historically, natural products and their structural analogs have played a significant role in pharmacotherapy, particularly in the treatment of infectious disorders and cancer [44] .…”

Section: Botanical Sourcesmentioning

confidence: 99%

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Bhuia,

Chowdhury,

Sonia

et al. 2024

Chemistry & Biodiversity

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Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with a multitude of pharmacological activities. The primary emphasis of this study is on summarizing the anticancer properties with the underlying mechanisms of RA and its derivatives, as well as the pharmacokinetic features. Data was collected (up to date as of November 10, 2023) from various reliable and authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings imply that RA and its synthetic derivatives possess promising anti‐cancer properties against breast, colorectal, liver, and cervical cancers in various preclinical pharmacological test systems. The results also indicate that RA and its derivatives demonstrated anticancer effects via a number of cellular mechanisms, including apoptotic cell death, inhibition of oxidative stress, anti‐inflammatory effect, cytotoxicity, cell cycle arrest, anti‐proliferative effect, anti‐angiogenic effect, and inhibition of cancer cell migration and invasion. It has been proposed that RA and its derived compounds have the capability to serve as a hopeful chemotherapeutic agent, so further extensive clinical research is necessary.

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Section: Botanical Sourcesmentioning

confidence: 99%

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Bhuia,

Chowdhury,

Sonia

et al. 2024

Chemistry & Biodiversity

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Longevity Spinach (Gynura procumbens) Ameliorated Oxidative Stress and Inflammatory Mediators in Cisplatin‐Induced Organ Dysfunction in Rats: Comprehensive in vivo and in silico Studies

Chandra Shill,

El‐Nashar,

Prova Mollick

et al. 2024

Chemistry & Biodiversity

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This study aimed to investigate the efficacy of Gynura procumbens (GP) leaf extract against cisplatin (CP)‐induced hepatorenal complications in Wister albino rats. Additionally, it aims to detect pol‐yphenolic compounds using high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD). The rats were treated intraperitoneally with CP (7.5mg/kg) to mediate hepatorenal damage. They were then treated with GP extract (75 and 150mg/kg, P.O.) for 7 consecutive days. CP‐mediated hepatorenal biomarkers like alkaline phosphatase, alanine aminotransferase, aspar‐tate aminotransferase, creatinine and blood urea nitrogen levels were normalized by GP extract in a dose‐dependent manner. Similarly, it significantly reduced CP‐induced oxidative stress inducers including nitric oxide and advanced oxidative protein products. Besides, it enhanced the antioxi‐dant enzymes, and glutathione levels. Histopathological studies showed that CP caused collagen accumulation in the liver and kidney tissues. GP extract drained the collagen mass and acted against hepatorenal damage. Ellagic acid, gallic acid, quercetin hydrate, kaempferol, and rutin hydrate were revealed in GP extract. In‐silico modelling showed good docking scores of the polyphenolic compounds with molecular targets including CYP4502E1, NF‐κB, caspase‐3, and TNF‐α. GP could be an effective therapeutic option for management of anticancer drugs’ complications like CP‐induced organ damage, although clinical studies are required to establish herbal formulation.

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A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives

Bhuia,

Chowdhury,

Akter

et al. 2024

Phytotherapy Research

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Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, and berry fruits. It is renowned for its several health advantages. The phytochemical is well known for its anticancer properties, and a substantial amount of clinical evidence has also established its promise as a chemotherapeutic agent. This study focuses on assessing the anticancer properties of resveratrol and gaining insight into the underlying molecular mechanisms. It also evaluates the biopharmaceutical, toxicological characteristics, and clinical utilization of resveratrol to determine its suitability for further development as a reliable anticancer agent. Therefore, the information about preclinical and clinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings from this study revealed that resveratrol has potent therapeutic benefits against various cancers involving different molecular mechanisms, such as induction of oxidative stress, cytotoxicity, inhibition of cell migration and invasion, autophagy, arresting of the S phase of the cell cycle, apoptotic, anti‐angiogenic, and antiproliferative effects by regulating different molecular pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, and so on. However, the compound has poor oral bioavailability due to reduced absorption; this limitation is overcome by applying nanotechnology (nanoformulation of resveratrol). Clinical application also showed therapeutic benefits in several types of cancer with no serious adverse effects. We suggest additional extensive studies to further check the efficacy, safety, and long‐term hazards. This could involve a larger number of clinical samples to establish the compound as a reliable drug in the treatment of cancer.

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Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Cited by 5 publications

References 93 publications

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Longevity Spinach (Gynura procumbens) Ameliorated Oxidative Stress and Inflammatory Mediators in Cisplatin‐Induced Organ Dysfunction in Rats: Comprehensive in vivo and in silico Studies

A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives

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