Phytochemical and Pharmacological screening of Coccinia grandis Linn.

Abstract

Ethanol extract of Coccinia grandis Linn. (Family- Cucurbitaceae) were subjected to Phytochemical screening, which showed the presence of Alkaloids, Reducing sugar and Saponins. The pharmacological interest of these compounds, coupled with the use of this plant in traditional medicine encouraged to check Coccinea grandis (Linn.) for possible antimicrobial, antidirrhoeal and analgesic activities. The ethanolic extract at the dose of 500 mg/kg exhibited marked action against pain, (p<0.001), percentage of protection was 60% while the standard drug diclofenac’s percent of protection was found to be 76% at a dose of 50 mg/kg body weight. It showed no antidiarrhoeal activity at the dose of 500 mg/kg body weight. The obtained results provide a support for the use of this plant for traditional medicine and for its further investigation.

Effect of Different Drying Methods on Antioxidant Activity and Availability of Phytochemicals in Leaves of Costus speciosus, Coccinia grandis and Gymnema sylvestre

“…The qualitative phytochemical screening test results were demonstrated in Table II Except for anthraquinones, the findings of the current qualitative analysis of phytochemicals indicated that all shade dried, oven-dried and freeze-dried leaf plant ethanolic extracts consisted of several bioactive compounds, including alkaloids, saponins, phenols, polyphenols, tannins, terpenoids, steroids, flavonoids, and phytosterols. Based on the results in Table II Previous studies reported that flavonoids and tannins were not present in sun-dried C. grandis leaf ethanolic extract [29]. In addition to that, [30] reported that the air-dried G. sylvestre leaf ethanolic extract was not contained terpenoids, steroids, coumarins and quinones.…”

Evaluation of the antibacterial activity of Coccinia grandis, against bacteria isolated from chronic suppurative otitis media infection

“…Aqueous and ethanolic extracts of the plant have shown hypoglycemic principles. This plant has been used to treat diabetics, skin diseases, and jaundice [18,19]. Antioxidant, antimutagenic, antibacterial, antiulcer, hepatoprotective, expectorants, and analgesic properties have been documented, and anthelmintic, cytotoxic, anti-diabetic, mast cellstabilizing, anti-anaphylactic, and antihistaminic potential, antimitotic, and anti-inflammatory activities also reported [20][21][22][23].…”

Ethnobotanical and Phytochemical Study of members of Cucurbitaceae from Ralegaon Region-A Review

“…[10] Antibacterial, antifungal, antimicrobial, antiulcer, antioxidant, anti-inflammatory, antihyperglycemic, anti-cancer, anti-diabetic, anti-hepatotoxic, anti-inflammatory, anti-helminthics, anti-virus, anti-bacterial, anti-microbial [10] 3 Coccinia grandis (L.) Voigt Ivy Gourd, Kundru, Tondli Steroid, carbohydrates, tannins, flavonoids, saponins, alkaloids bamyrine, lupeol, cucubbitacin, cephalandrol, cephalandrine. [15] Antibacterial, Anthelmintic, Antioxidant, antiulcer, antimalarial, anti-inflammatory, antipyretic, analgesic, hypoglycaemic, antifungal, Anti-dyslipidemic, Antitussive, anticancer, antitussive, mutagenic activity. [14] 4…”