In search of new therapeutic alternatives, scientific community had studied many kinds of mushrooms and have been shown to contain valuable sources of bioactive agents that result in beneficial health effects such as antitumor, anticancer, antiviral, anti inflammatory and hypolipidemic activity. The most significant medicinal effects of mushrooms derived compounds, both cellular components and secondary metabolites, have been shown to stimulate the immune system and could be used to treat variety of diseases, including Cancers. So these medicinal mushrooms can be called as "Immunomodulators" or "Biological Response Modifiers (BRMS)", "Immunopotentiators" and "Immunostimulant".