Abstract:Genus Syringa, belonging to the Oleaceae family, consists of more than 40 plant species worldwide, of which 22 species, including 18 endemic species, are found in China. Most Syringa plants are used in making ornaments and traditional medicines, whereas some are employed for construction or economic use. Previous studies have shown that extracts of Syringa plants mainly contain iridoids, lignans, and phenylethanoids that have antitumor, antihypertensive, anti-oxidant, and anti-inflammatory activities. This stu… Show more
“…Based on these works the main phenolics in Syringa species are phenylpropanoids and iridoid‐glycosides, such as acteoside (syn. verbascoside) and oleuropein (Bi et al ., ; Birkofer et al ., ; Kurkin et al ., , ; Su et al ., ).…”
“…Based on these works the main phenolics in Syringa species are phenylpropanoids and iridoid‐glycosides, such as acteoside (syn. verbascoside) and oleuropein (Bi et al ., ; Birkofer et al ., ; Kurkin et al ., , ; Su et al ., ).…”
“…The genus Syringa L. is widely spread in various regions of the world due to its decorativeness, while the data on the number of species are contradictory [16], [27]. Some researchers believe that there are 40 species of lilacs spreading both in Europe and in Asia [27].…”
Section: Introductionmentioning
confidence: 99%
“…Some researchers believe that there are 40 species of lilacs spreading both in Europe and in Asia [27]. According to other sources, the genus Syringa L. includes 27 species, 25 of which come from Asia and only 2 from Europe [16].…”
Abstract. This article presents the data of the morpho-physiological analysis of the reproductive buds of Syringa josikaea Jacq. that was introduced in the city of Murmansk located in the Far North of Russia. It is shown, that in the conditions of the Arctic climate, the beginning of differentiation of the axes of the inflorescences and the organogenesis of flowers can occur both: a year before blooming and in the spring period, two-three months before its beginning. The polyvariance of the floral organogenesis in cenopopulations of the S. josikaea of Murmansk city has been revealed. Experimental data on the polyvariance of the organogenesis of reproductive organs of lilac are first obtained in the Arctic urbanized territory.
“…Syringa iridoids are generally substituted by various acid fragments and phenolic moieties such as 3, 4-dihydroxy-phenethyl, or caffeic acid, which contribute to their low polarity [8], and the structural similarity of which are very high.…”
Section: Accepted M Manuscriptmentioning
confidence: 99%
“…IGs are one of the most important natural compounds that are widely distributed in various plant families, which are extensively present in almost all Syringa species and have antimicrobial, antihypertensive, anti-inflammatory, anti-oxidant, and antitumor activities [8].…”
The antibacterial activity of syringopicroside, its metabolites and natural analogues from syringae folium, Fitoterapia (2016), doi: 10.1016/j.fitote. 2016.02.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT
AbstractIn the present study, the in vitro antibacterial activity of an effective fraction (ESF) from Syringae Folium (SF) on Methicillin-resistant Staphylococcus aureus (MRSA) was evaluated and then its in vivo activity was evaluated by using the MRSA-infected mouse peritonitis model. The ESF showed a significant in vitro and in vivo activity on decreasing the Minimum Inhibitory Concentrations (MICs) and increasing the survival rate of mouse from 42.8% to 100%. Six iridoid glucosides (IGs) of ESF were characterized by UPLC-TOF-MS method and also isolated by column chromatography. Most of them showed in vitro anti MRSA activity. Syringopicroside (Sy), the major compound of IGs, was found to increase the survival rate from 42.8% to 92.8% of the MRSA-infected mouse, which revealed Sy is also the main active components of ESF. In order to know why the effect of oral administration of SF is better than its injections in clinic and the metabolites of Sy, seven metabolites of Sy were isolated from rat urine and identified on the basis of NMR and MS spectra. Most of metabolites possessed stronger in vitro anti-MRSA activity than that of Sy, which furtherly proved the clinical result.
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