Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insects

Abstract

The objective of the current study was to examine the phytochemical and in vitro thrombolytic, anti-arthritic, anthelmintic, and insecticidal effects of Trewia nudiflora (TN) methanolic leaf extract with its methanol (MTN), chloroform (CTN), and ethyl acetate (ETN) fractions. Pheretima posthuma and Tribolium castaneum were employed for evaluating the antihelmintic and insecticidal properties, respectively. All the tested extracts showed the presence of copious potential constituents in phytochemical analysis. Among all extracts, MTN extract exhibited the utmost clot lysis (35.95 ± 4.81%) property compared to standard streptokinase (SK) (53.77 ± 7.52%). All samples displayed striking protein denaturation activity in a dose-dependent manner (100–500 µg/mL), where the highest inhibition was observed for MTN (67.26 ± 6.39% at 500 µg/mL). Each extract demonstrated considerable anthelmintic activity at 25–75 mg/mL dose ranges. ETN showed the strongest anthelmintic activity at the highest dose. Among all samples, the CTN extract displayed the utmost mortality rate (77.22%) in the insecticidal test. The results of the study suggest that T. nudiflora leaf extracts may have potential against thrombosis, arthritis, helminths, and insects, which warrants the necessity of extensive isolation and identification of bioactive compounds to develop newer effective drugs upon preclinical and clinical investigations.

Two rare flavonoid glycosides from Litsea glutinosa (Lour.) C. B. Rob.: experimental and computational approaches endorse antidiabetic potentiality

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Stixis suaveolens (Roxb.) Fruit Extract Deciphered Antidepressant and Antidiarrheal Effects via In vivo Approach

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The Allelopathic Effects of Trewia nudiflora Leaf Extracts and Its Identified Substances

“…Moreover, phytochemical profiling of T. nudiflora leaf extracts found that this plant included different classes of bioactive compounds, such as flavonoids, phenols, tannins, saponins, etc. ; however, their allelopathic actions have not been elucidated [ 41 ]. Therefore, the purpose of this research was to reveal the plant’s allelopathic effect as well as to isolate and determine the molecular characterization of the allelopathic substances from the leaf extract of T. nudiflora .…”