Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb.

Abstract

Background Traditionally, the herb Byttneria pilosa Roxb. is used for bone fractures, boils, scabies, rheumatalgia, snake bites, syphilis, elephantiasis, poisoning, and eye infection. Scientific reports suggest that it has significant anti-inflammatory, analgesic, anti-diarrheal, anxiolytic, locomotion, sedative and anti-obesity effects. This study aims at the investigation of the phytochemical and pharmacological properties of the ethanol extract of this herb. Methods Fresh whole plant was extracted with absolute ethanol. A preliminary phytochemical investigation was followed by the evaluation of thrombolytic, anti-inflammatory, and anti-nociceptive activities by applying human clotted blood lysis, egg albumin, and acetic acid-induced writhing models, respectively. Results Phytochemical investigation suggests that B. pilosa possesses alkaloids, flavonoids, glycosides, terpenoids, tannins, saponins, and reducing sugars. The extract exhibited clot lysis and anti-inflammatory effects in a concentration-dependent manner. B. pilosa extract at 250 and 500 mg/kg also showed significant (p < 0.05) dose-dependent anti-nociceptive activity in Swiss albino mice. Conclusion The B. pilosa ethanol extract contains many important secondary metabolites and has thrombolytic, anti-inflammatory, and anti-nociceptive activities. More research is necessary on this hopeful medicinal herb.

Bioactivity Profiling of Daedaleopsis confragosa (Bolton) J. Schröt. 1888: Implications for Its Possible Application in Enhancing Women’s Reproductive Health

“…Even though Fakoya et al [64] did not detect tannins and phenols in the EtOH extract of D. confragosa from Nigeria, this solvent is effective for the extraction of terpenoids, especially after the HD procedure. Hence, we assume that the DCHD extract also likely contains saponins, which are glycosides containing terpenoids or steroids [45,65]. This assumption was based on previous research, where the reactions typical of the detection of saponins themselves, observed in the species Meripilus giganteus, were foaming along with hemolysis of the cell membrane of erythrocytes [66].…”

Anti-oxidant and neuro-modulatory effects of bioactive Byttneria pilosa leaf extract in swiss albino mice using behavioral models

“…In Tripura, elephantiasis is treated externally by applying the root of B. pilosa to afflicted areas ( Jyoti et al, 2020 ). Phytochemical analysis of the whole plant has revealed the presence of phenols, tannins, steroids, alkaloids, glycosides, flavonoids, saponins, and terpenoids ( Sikder et al, 2022 ). There has been limited exploration into the pharmacological potential of the leaf of B. pilosa .…”

In vitro Anti-inflammatory, Antioxidant and Membrane Stabilization Activities of Leaf Extracts of Byttneria pilosa Roxb

“…This plant is characterized as a glabrous herb that completes its life cycle within a year, making it suitable for annual cultivation. It reproduces through seeds and reaches maturity during the winter season (Sikder et al, 2022).…”