Phytochemical and pharmacological aspects of Tephrosia genus: A brief review

Abstract

Tephrosia, the plant genus belongs to the family Fabaceae. It belongs to the major group of angiosperms (flowering plants) that comprises more than 350 species which is widely distributed in the regions of tropical and subtropical countries of the world. Since the herbal medicine is in demand due to its fewer associated side effects, the genus Tephrosia is extensively used for the treatment of large number of diseases in traditional medicines. The main aim of this review is to summarize and document the phytochemical and pharmacological activities performed on Tephrosia genus. To promote the continual use of these plants and in order to plan for the future studies, it becomes important to provide a basis by combining a number of available information into a single data covering the different aspects of the plant.

Anti-inflammatory Flavanones and Flavones from Tephrosia linearis

“…(Fabaceae) mainly inhabit tropical and subtropical regions with over 30 species occurring in Kenya . Many of the species have been used ethnomedicinally to alleviate diverse illnesses. , Phytochemical investigations of some of these plants by our research group have led to the isolation of a chalcone, rotenoids, flavanonols, and flavones that are biologically active. Also, the genus Tephrosia is reported to elaborate other bioactive flavonoids such as flavanones, isoflavones, and pterocarpans. , Some of these flavonoids also exhibit anti-inflammatory properties.…”

Antimicrobial investigation of Tephrosia Vogelii hook.f from Hai District in Tanzania towards development of antifungal agents for topical application

“…Also, this study on phytochemical screening revealed the absence of alkaloids and anthraquinones suggesting that these medicinal properties of Tephrosia vogelii found particularly in Tanzania may be branded mainly by tannins, steroids, terpenes, flavonoids and glycosides. On the other hand, the chemical nature of the phytochemicals analysed from this medicinal plant clearly coincides with the antimicrobial activities and ectoparasitic activities reported in the previous studies (Alamgir, 2017;Arif et al, 2011;Badri et al, 2017;Kenechukwu et al, 2012;Irawan et al, 2018;Makoshi & Arowolo, 2011;Mbunde et al, 2016;Mlozi et al, 2020;Murtaza et al, 2015;Nneka & Jude, 2012;Okpogba et al, 2019;Omodamiro & Amechi, 2013;Pietta, 2000;Priya et al, 2014;Ramawat & Mérillon, 2013;Sahu et al, 2014;Samuel et al, 2019;Sasidharan et al, 2011;Singh et al, 2017;Swamy et al, 2015;Trakranrungsie, 2011).…”

“…On the other hand, pharmacological studies of Swamy and colleagues (2015) pointed-out the usefulness of Tephrosia vogelii as a medicinal plant for management of bacterial diseases (Inalegwu & Sodipo, 2015;Swamy et al, 2015). The biological assay of ether-ethanolic extracts of Tephrosia vogelii seeds showed that the extracts exhibit anti-oxidants and free scavenging properties, and hence indicated the presence of flavonoids which have been reported to be responsible for such antioxidant and free radical scavenging properties (Samuel et al, 2019). Other studies reported that the methanolic extracts of Tephrosia vogelii also exhibited purgative activities after being subjected to the rabbit (Samuel et al, 2019).…”

“…The biological assay of ether-ethanolic extracts of Tephrosia vogelii seeds showed that the extracts exhibit anti-oxidants and free scavenging properties, and hence indicated the presence of flavonoids which have been reported to be responsible for such antioxidant and free radical scavenging properties (Samuel et al, 2019). Other studies reported that the methanolic extracts of Tephrosia vogelii also exhibited purgative activities after being subjected to the rabbit (Samuel et al, 2019). Moreover, extracts of Tephrosia vogelii stem barks containing flavonoids were reported to exhibit anti-cancer activities (Gbadamosi & Erinoso, 2016).…”

Tephrosia purpurea Ameliorates Oxidative and Histological Alterations Induced by Aflatoxin B1 in Rats

“…Extract of TP possess free radical scavenging activity and antioxidant properties due to presence of various phytochemicals like alkaloids, amino acids, glycosides, sterols, rotenoids, isoflavones, flavanones, flavonoids, chalcones, flavanols, flavones, saponins, reducing sugars, terpenes and tannis. [9][10][11] Due to presence of these phytochemicals, it has a peculiar property of curing all types of wounds. Hence, it is known as "Sarwa wranvishapaka".…”