Anti-inflammatory Flavanones and Flavones from <i>Tephrosia linearis</i>

Owor, Richard Oriko; Bedane, Kibrom Gebreheiwot; Zühlke, Sebastian; Derese, Solomon; Ong’amo, George; Ndakala, Albert; Spiteller, Michael

doi:10.1021/acs.jnatprod.9b00922

Cited by 19 publications

(13 citation statements)

References 32 publications

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“…Phytochemical investigation reveals the chemical nature of the pure compounds that are responsible for the pharmacological activity as well as the toxicity of medicinal plants [19,64,[98][99][100][101]. Chromatographic and spectroscopic techniques are used to identify and elucidate the chemical structures of compounds [102][103][104][105][106][107].…”

Section: Phytochemistry Of the Reported Plantsmentioning

confidence: 99%

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

et al. 2020

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Objective Many studies on the treatment of tuberculosis (TB) using herbal medicines have been undertaken in recent decades in East Africa. The details, however, are highly fragmented. The purpose of this study was to provide a comprehensive overview of the reported medicinal plants used to manage TB symptoms, and to analyze scientific reports on their effectiveness and safety. Method A comprehensive literature search was performed in the major electronic databases regarding medicinal plants used in the management of TB in East Africa. A total of 44 reports were retrieved, and data were collected on various aspects of the medicinal plants such as botanical name, family, local names, part(s) used, method of preparation, efficacy, toxicity, and phytochemistry. The data were summarized into percentages and frequencies which were presented as tables and graphs. Results A total of 195 species of plants belonging to 68 families and 144 genera were identified. Most encountered species were from Fabaceae (42.6%), Lamiaceae (19.1%), Asteraceae (16.2%), and Euphorbiaceae (14.7%) families. Only 36 medicinal plants (18.5%) have been screened for antimycobacterial activity. Out of these, 31 (86.1%) were reported to be bioactive with minimum inhibitory concentrations ranging from 47 to 12,500 μg/ml. Most tested plant extracts were found to have acceptable acute toxicity profiles with cytotoxic concentrations on normal mammalian cells greater than 200 μg/ml. The most commonly reported phytochemicals were flavonoids, terpenoids, alkaloids, saponins, cardiac glycosides, and phenols. Only Tetradenia riparia , Warburgia ugandensis , and Zanthoxylum leprieurii have further undergone isolation and characterization of the pure bioactive compounds. Conclusion East Africa has a rich diversity of medicinal plants that have been reported to be effective in the management of symptoms of TB. More validation studies are required to promote the discovery of antimycobacterial drugs and to provide evidence for standardization of herbal medicine use.

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Section: Phytochemistry Of the Reported Plantsmentioning

confidence: 99%

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

et al. 2020

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“…They were also observed for signs of toxicity and death for the first 2 hours and intermittently for 24 hours. The LD50 value was estimated by calculating the geometric mean of the lowest dose that I. Muhwana et al / J. Pharmacy & Bioresources 17 (1), 19-23 (2020) caused death and the highest dose for which the animals survived.…”

Section: Methodsmentioning

confidence: 99%

“…Inflammatory diseases and pain are a common cause of morbidity and mortality worldwide [1]. Therapeutic management of these conditions involve the use of nonsteroidal anti-inflammatory drugs, corticosteroids and opioid analgesics [2].…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive and anti-inflammatory activities of the aqueous leaf extract of<i> Erlangea tomentosa</i> (Asteraceae) in rats and mice

Muhwana¹,

Obakiro²,

Ibanda³

et al. 2020

J. Pharm Bio.

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Erlangea tomentosa (Asteraceae) is used traditionally in the preparation of herbal remedies for management of several diseases including pain and inflammation. However, its efficacy and safety have not been scientifically validated. The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of the aqueous leaf extract of this plant and its acute toxicity profile in animal models. Antinociceptive activity and anti-inflammatory activity were determined using the acetic acid-induced writhing model in mice and carrageenan induced inflammation model in ratsrespectively. The oral median lethal dose (LD50) was determined using the Lorke’s Method. The extract inhibited pain due to acetic acid significantly (p<0.05) at doses of 250 mg/kg and 500 mg/kg. The inflammation due to carrageenan was also significantly (p<0.05) reduced at dose of 500 mg/kg body weight but not 250 mg/Kg. The LD50 value of the extract was greater than 5,000 mg/kg implying that the extract was safe in 24 hours when administered in a single high oral dose. Preliminary phytochemical screening revealed the presence of alkaloids, anthraquinones, coumarins, saponins, tannins and resins. The present study has demonstrated the antinociceptive and anti-inflammatory potential of aqueous leaf extract of Erlangea tomentosa in rats and mice; thus validates the folkloric use of the plant. Keywords: Erlangea tomentosa; Antinociception; Anti-inflammation; Acetic acid; Carrageenan

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“…The cytokine release inhibition assays were performed by Pharmacelsus, Saarbrücken, Germany according to previously published procedures [33][34][35]. The PBMCs were isolated from blood ethically collected from 4 healthy donors with the ethnicity Caucasian (male, 41 y old), African-American (male, 31 y old), African American-Hispanic (male, 29 y old), and Caucasian (male, 32 y old).…”

Section: Cytokine Release Inhibition Assaysmentioning

confidence: 99%

Inhibition of Proinflammatory Cytokine Release by Flavones and Flavanones from the Leaves of Dracaena steudneri Engl.

et al. 2020

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The leaves of Dracaena steudneri yielded 6 new flavonoids–3,5,7-trihydroxy-6-methyl-3′,4′-methylenedioxyflavone (1), 5,7-dihydroxy-3-methoxy-6-methyl-3′,4′-methylenedioxyflavone (2), 3,5,7-trihydroxy-6-methoxy-3′,4′-methylenedioxyflavone (3), (2S,3S)-3,7-dihydroxy-6-methoxy-3′,4′-methylenedioxyflavanone (4), 4′,5,7-trihydroxy-3,3′,8-trimethoxy-6-methylflavone (5), (2R) 7-hydroxy-2′,8-dimethoxyflavanone (6)–together with 13 known congeners. Their structures were established using spectroscopic and spectrometric methods including NMR, CD, and HRMSn measurements. The compounds were evaluated for their anti-inflammatory potential through measurement of the levels of cytokines IL-1β, IL-2, GM-CSF, and TNF-α in the supernatant of human peripheral blood mononuclear cells stimulated by lipopolysaccharide. Flavones derivatives 1–4 with a C-3′/4′ methylenedioxy substituent led to a substantial increase in the production of IL-1β and GM-CSF out of 4 pro-inflammatory cytokines relative to LPS control. Quercetin derivatives 5, 11, and 13 with a hydroxyl group at C-4′ inhibited the production of IL-2, GM-CSF, and TNF-α. The presence of a C-2/C-3 double bond in 14 was pivotal to the significantly stronger (0.4 to 27.5% of LPS control) inhibitory effect compared to its dihydro derivative 8 (36.2 to 262.7% of LPS control) against all tested cytokines. It is important to note that the inhibitory activity of 14 was substantially higher than that of the standard drug used, ibuprofen.

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Anti-inflammatory Flavanones and Flavones from Tephrosia linearis

Cited by 19 publications

References 32 publications

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review

Antinociceptive and anti-inflammatory activities of the aqueous leaf extract of<i> Erlangea tomentosa</i> (Asteraceae) in rats and mice

Inhibition of Proinflammatory Cytokine Release by Flavones and Flavanones from the Leaves of Dracaena steudneri Engl.

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