Antinociceptive and anti-inflammatory activities of the aqueous leaf extract of<i> Erlangea tomentosa</i> (Asteraceae) in rats and mice

Abstract

<jats:p>Erlangea tomentosa (Asteraceae) is used traditionally in the preparation of herbal remedies for management of several diseases including pain and inflammation. However, its efficacy and safety have not been scientifically validated. The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of the aqueous leaf extract of this plant and its acute toxicity profile in animal models. Antinociceptive activity and anti-inflammatory activity were determined using the acetic acid-induced writhing model in mice and carrageenan induced inflammation model in ratsrespectively. The oral median lethal dose (LD50) was determined using the Lorke’s Method. The extract inhibited pain due to acetic acid significantly (p&lt;0.05) at doses of 250 mg/kg and 500 mg/kg. The inflammation due to carrageenan was also significantly (p&lt;0.05) reduced at dose of 500 mg/kg body weight but not 250 mg/Kg. The LD50 value of the extract was greater than 5,000 mg/kg implying that the extract was safe in 24 hours when administered in a single high oral dose. Preliminary phytochemical screening revealed the presence of alkaloids, anthraquinones, coumarins, saponins, tannins and resins. The present study has demonstrated the antinociceptive and anti-inflammatory potential of aqueous leaf extract of Erlangea tomentosa in rats and mice; thus validates the folkloric use of the plant.&#x0D; Keywords: Erlangea tomentosa; Antinociception; Anti-inflammation; Acetic acid; Carrageenan </jats:p>

Antibacterial, antioxidant, and sun protection potential of selected ethno medicinal plants used for skin infections in Uganda

“…E . tomentosa has been reported to contain resins, anthraquinones, and coumarins [ 25 ]. Also, plants belonging to the genus Plectranthus have been reported to contain free aglycone and triterpenes [ 13 ].…”

“…According to Ntemafack, aqueous extract of S. princeae contains some compounds that may either prolong the intestinal transit, excite directly the central nervous system, or possesses nephroprotective and hematoprotective effect when administered orally at middle doses. According to Muhwana et al [ 25 ], the aqueous leaf extract of E. tomentosa is safe when orally administered in a single dose (up to 5000 mg/kg) within 24 h. The stem bark of P . febrifugum is reported non-toxic even at higher dose of 5000 mg/kg body weight [ 4 ].…”

“…Ethnobotanical surveys were carried out by Namukobe et al [ 28 ] and Asiimwe et al [ 3 ]; these reports were based on to select the plants and parts used in this study. For example, S. princeae fresh leaves are squeezed and applied on wounds [ 27 , 28 ], the leaves of E. tomentosa are widely used by traditional herbal medicine practitioners to prepare herbal remedies for management of skin infections [ 25 ]. The stem bark of P. febrifugum powder is mixed in Vaseline for treating skin rashes [ 40 ].…”

A Hydroethanolic Leaf Extract of Persicaria lanigera Possesses Antinociceptive Activity through Cytokine and Glutamatergic Pathways In Vivo

“…ey were fed with a normal commercial pellet diet and given clean water ad libitum. e animals were acclimatized to the laboratory environment for seven (7) days before performing the experiments. All procedures and techniques used in these studies were performed following the National Institute of Health Guidelines for the Care and Use of Laboratory Animals.…”

Comparative Studies of Phytochemical and Antimicrobial Activity oc Carica papaya L. Extracts against Escherichia coli, Staphylococcus aureus and Candida albicans

“…Current estimates indicate that about 80 million people worldwide still depend on plants for their health needs (Dwivedi et al, 2020). Limited access to primary health care in developing countries has resulted into widespread use of herbal medicines due to the availability, accessibility, affordability and cultural acceptance across different ethnic backgrounds (Muhwana et al, 2020). There is widespread use of broadspectrum antibiotics which has led to the emergence of nosocomial infections caused by drug resistant microbes (Abubakar, 2009).…”