Phytochemical and In-Vivo Anti-Arthritic Significance of Aloe thraskii Baker in Combined Therapy with Methotrexate in Adjuvant-Induced Arthritis in Rats

Kamal, Rania M.; Sabry, Manal M.; Aly, Zeinab Y; Hifnawy, Mohamed S.

doi:10.3390/molecules26123660

Cited by 13 publications

(6 citation statements)

References 40 publications

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“…CFA-induced arthritis is one of the most common and widely accepted methods for mimicking RA in animal models due to the similarities with the clinical features of human arthritis. 19,20 Consistent with previous studies, the CFA-induced arthritis rats displayed significant decrease in body weight gain, significantly increased paw bulbous swelling and redness, limp and paw edema as well as joint deformation, suggesting the development of spontaneous inflammation. 7,16 Treatment with DHZ significantly suppressed the increased arthritis score as well as paw oedema and swelling in the treated RA rats.…”

Section: Discussionsupporting

confidence: 87%

Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats

Liu¹,

Li²,

Wen³

et al. 2022

DDDT

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Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease with severe inflammatory responses. Dehydrozingerone (DHZ) is a potent bioactive compound found in the rhizomes of Zingiber officinale, and it has been reported as an excellent anti-inflammatory and antioxidant agent. This study evaluated the anti-arthritic effects of DHZ in complete Freund’s adjuvant (CFA)-induced arthritis. Methods CFA administered rats were intragastrically treated with DHZ (100 mg/kg) for 28 days, and arthritis severity was assessed via body weight, arthritic score, paw edema and hyperalgesia. Serum inflammation biomarkers, oxidative stress markers, inflammatory cytokines and liver function enzymes were evaluated. Results The results indicated that DHZ significantly ameliorated arthritis severity as shown by reduced arthritic score, thymus and spleen indexes, paw circumference, paw withdrawal threshold and latency as well as increased body weight gain. Furthermore, DHZ treatment persuasively reduced serum levels of alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), rheumatoid factor (RF), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin-1β and 6 (IL-1β and IL-6), malondialdehyde (MDA), vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β). In addition, DHZ observably increased serum superoxide dismutase (SOD) and glutathione (GSH) levels in treated rats. Conclusion These findings suggest that DHZ possesses anti-RA effect properties via modulating the inflammatory responses and oxidative stress.

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Section: Discussionsupporting

confidence: 87%

Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats

Liu¹,

Li²,

Wen³

et al. 2022

DDDT

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“…In addition, it caused a partial increase in CAT activity. In previous studies, it was stated that GSH level decreased, MDA level increased, [ 65 ] and SOD and CAT activities decreased in CFA‐induced RA model. [ 66 ] In general, the positive effects of safranal can be seen on oxidative stress markers.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats

Cellat

İşler

Kutlu

et al. 2022

J Biochem & Molecular Tox

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Rheumatoid arthritis (RA) is a systemic chronic disease characterized by inflammation and synovitis. More effective treatment methods with less side effects need to be developed. In this context, current study investigated the therapeutic effects of safranal in a model of complete Freund's adjuvant (CFA)‐induced RA. The control group was given 1 ml of saline orally starting from the 8th day, and 0.2 ml of CFA was given to the RA, RA + Safranal and RA + Methotrexate (MTX) groups on the 0th day of the experiment. Starting from the 8th day of the experiment, 1 ml of saline was given to the RA group, safranal was given at 200 mg/kg of body weight to the RA + MTX group, and 3 mg/kg of MTX to the RA + MTX group twice a week. The results showed that weight gain decreased in the RA group compared to the control group while arthritis index score, thymus index, and planter temperature were found to be increased. Additionally, a deterioration in blood parameters, an increase in alanine aminotransferase, aspartate aminotransferase, urea, creatinine, C‐reactive protein, and malondialdehyde levels, and a decrease in reduced glutathione levels and glutathione peroxidase and catalase (CAT) activities were seen while tumor necrosis factor‐α, interleukin‐6 (IL‐6), cyclooxygenase‐2, nuclear factor kappa B levels were found to be increased. However, the safranal had a regulatory effect on all the values, except IL‐6 and CAT, and blood parameters. Moreover, histopathological examination revealed that safranal reduced inflammatory cell infiltration and edema.

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“…Biochemical considerations i.e., ALP, AST, and ALT were estimated by commercial kits and manufacture directions (Modern Lab, Maharashtra, India) ( Kamal et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Protective effect of fustin against adjuvant-induced arthritis through the restoration of proinflammatory response and oxidative stress

Alshehri

AlGhamdi

Alghamdi

et al. 2023

PeerJ

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Rheumatoid arthritis causes irreparable damage to joints. The present research sought to check fustin’s anti-arthritic efficacy against the complete Freund’s adjuvant-induced arthritis paradigm in animals by altering the inflammatory response. In the rats, complete Freund’s adjuvant was used to trigger arthritis and they received fustin at 50 and 100 mg/kg for 21 days. At regular intervals, the hind paw volume and arthritic score were assessed. After the trial period, hematological, antioxidant, pro-inflammatory cytokines, and other biochemical parameters were estimated. Fustin-treated rats showed the down-regulation of hind paw volume, arthritic score, and altered hematological parameters (TLC, DLC (neutrophil, lymphocyte, monocyte, eosinophil, basophil)). Furthermore, fustin significantly mitigates proinflammatory cytokine (reduced interleukin, tumor necrosis factor-a (TNF-α), IL-6, IL-1β), oxidative stress (attenuated malondialdehyde (MDA), catalase (CAT), glutathione (GSH), superoxide dismutase (SOD)), attenuated production of prostaglandin E2 and myeloperoxidase (MPO) and improved nuclear factor erythroid 2-related factor (Nrf2) action. Fustin led to the benefit in arthritis-prone animals elicited by complete Freund’s adjuvant via pro-inflammatory cytokine.

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Phytochemical and In-Vivo Anti-Arthritic Significance of Aloe thraskii Baker in Combined Therapy with Methotrexate in Adjuvant-Induced Arthritis in Rats

Cited by 13 publications

References 40 publications

Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats

Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats

Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats

Protective effect of fustin against adjuvant-induced arthritis through the restoration of proinflammatory response and oxidative stress

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