Phytochemical and in vitro antimicrobial and genotoxic activity in the brown algae Dictyopteris membranacea

Akremi, Najoua; Cappoen, Davie; Anthonissen, Roel; Verschaeve, Luc; Bouraoui, Abderrahman

doi:10.1016/j.sajb.2016.08.009

Cited by 29 publications

(16 citation statements)

References 41 publications

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“…Negative control included SDB medium with DMSO while clotrimazole served as positive control standard. Furthermore, MFC/MIC ratio was calculated against each fungal and yeast strain depicting whether the antifungal effect is fungicidal or fungistatic [ 33 ]. …”

Section: Methodsmentioning

confidence: 99%

Phytochemical investigation and antimicrobial appraisal of Parrotiopsis jacquemontiana (Decne) Rehder

Ali

Khan

Ullah

et al. 2018

BMC Complement Altern Med

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BackgroundParrotiopsis jacquemontiana (Decne) Rehder. is locally used for skin infections and in wound healing. In this study we have evaluated methanol extract of its leaves and derived fractions against the clinical multi-drug resistant bacterial strains.MethodsP. jacquemontiana leaves powder extracted with 95% methanol (PJM) and fractionated in escalating polarity of solvents; n-hexane (PJH), chloroform (PJC), ethyl acetate (PJE), n-butanol (PJB) and the remaining as aqueous fraction (PJA). Clinical as well as environmental 19 bacterial strains and 8 fungal strains were screened for minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC). Preliminary phytochemical investigation for various phytochemical classes was also carried out.ResultsPJM contained the coumarins, phenols, flavonoids, tannins, alkaloids, glycosides, saponins, sterols, phlobatannins, steroids, phytosterols, triterpenoids, acids, quinones, proteins, vitamin C, betacyanins, oils and resins while anthraquinones, phytosteroids, carbohydrates and anthocyanins were not detected. Disc diffusion assay (1 mg/disc) indicated the sensitivity of all the MDR strains of bacteria with PJM, PJE and PJB, while no inhibition was recorded with PJA. PJH and PJC inhibited the growth of all the strains of Staphylococcus aureus, Pseudomonas aeruginosa and Coagulase negative staphylococci used in this study. Maximum zone of inhibition (35.5 ± 1.32 mm) was obtained with PJM against Staphylococcus lugdenesis MDR (6197). Comparatively lower MIC (8-64 μg/ml) and MBC (32-256 μg/ml) values were recorded for PJM and PJE. In case of fungal strains only PJM, PJE and PJB markedly inhibited the growth and lower MIC (8-128 μg/ml) and MFC (32-512 μg/ml) values were determined for PJM and PJE.ConclusionThe remarkable inhibition of various bacterial and fungal strains at low doses of the extract/fractions suggested the strong antibacterial, antifungal and anti-candidal potential of P. jacquemontiana leaves.

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Section: Methodsmentioning

confidence: 99%

Phytochemical investigation and antimicrobial appraisal of Parrotiopsis jacquemontiana (Decne) Rehder

Ali

Khan

Ullah

et al. 2018

BMC Complement Altern Med

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“…Nevertheless, there is no standard way to carry out a qualitative evaluation. Furthermore, different authors have used different scales [ 28 , 29 , 30 , 31 ]. Therefore, to standardize the classification, this review will adopt the classification proposed by the Clinical and Laboratory Standards Institute (CLSI).…”

Section: Antibacterial Potential Of Bioactive Compounds From Macromentioning

confidence: 99%

“…The most studied species are brown algae, followed by the red and finally the green algae. As it can be seen in Table 1 , brown algae [ 28 , 50 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ] promoted inhibition growth zones larger than 15 mm diameter, allowing the antibacterial activity categorization of intermediate or susceptible. Minimal inhibition concentration (MIC) values ranging from 7.5 mg/L to 0.16 mg/L were achieved when an acetone-based crude extract of Cutleria multifida was used [ 42 ].…”

Section: Antibacterial Potential Of Bioactive Compounds From Macromentioning

confidence: 99%

“…Overall, the most studied salmonella species in antimicrobial tests performed with alga extracts is Salmonella Typhi. Studies made with these bacteria species allow the classification of the antimicrobial activity of intermediate to susceptible (diameter of the inhibition growth zone higher than 15 mm) from the Phaeophyta phylum: D. membranacea [ 28 ], P. gymnospora [ 47 ], D. dichotoma var intricate (B), D. indica (B) [ 57 ], S. lomentaria (B) [ 54 ], and Ecklonia cava [ 109 ]. Among the Chlorophytes and Rhodophytes, U. rigida and C. officinalis [ 50 ] also present antagonistic effects to S. Typhi.…”

Section: Antibacterial Potential Of Bioactive Compounds From Macromentioning

confidence: 99%

“…was the most studied genus [ 41 , 57 , 73 , 76 , 99 , 118 , 129 , 130 ]. Comparing solvent performance for bioactive compounds extraction, the following results were obtained: ethanol or acetone > crude extract or MeOH/DCM for D. membranacea [ 28 ], EtOAc > EtOH > hexane, DCM, n-BuOH, water (H 2 O) for E. cava [ 109 ]; EtOAc > DCM, BuOH> hexane > MeOH for E. bicyclis [ 121 ]; H 2 O > MeOH, acetone or ethyl acetate for F. serratus [ 131 ]; ethanol > hexane > H 2 O for H. elongata [ 21 ]; ethylacetate > MeOH for P. antillarum and P. boergeseni [ 66 ]; MeOH > acetone for S. platycarpum and for S. latifolium [ 118 ]. It can be concluded that there is not a common solvent to extract compounds with antibacterial activity against S. aureus.…”

Section: Antibacterial Potential Of Bioactive Compounds From Macromentioning

confidence: 99%

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Antibacterial Use of Macroalgae Compounds against Foodborne Pathogens

Silva

Lourenço-Lopes

et al. 2020

Antibiotics

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The search for food resources is a constant in human history. Nowadays, the search for natural and safe food supplies is of foremost importance. Accordingly, there is a renewed interest in eco-friendly and natural products for substitution of synthetic additives. In addition, microbial contamination of food products during their obtaining and distribution processes is still a sanitary issue, and an important target for the food industry is to avoid food contamination and its related foodborne illnesses. These diseases are fundamentally caused by certain microorganisms listed in this review and classified according to their Gram negative or positive character. Algae have proven to possess high nutritional value and a wide variety of biological properties due to their content in active compounds. Among these capabilities, macroalgae are recognized for having antimicrobial properties. Thus, the present paper revises the actual knowledge of microbial contaminants in the food industry and proposes antimicrobial algal compounds against those pathogenic bacteria responsible for food contamination as valuable molecules for its growth inhibition. The capacity of algae extracts to inhibit some major food pathogen growth was assessed. Moreover, the main applications of these compounds in the food industry were discussed while considering their favorable effects in terms of food safety and quality control.

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