Phytochemical and Biological Potential of Cassia tora Linn.

Sarwa, Khomendra Kumar

doi:10.9734/ejmp/2014/8549

Cited by 7 publications

(3 citation statements)

References 54 publications

(56 reference statements)

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“…According to the literature survey, secondary metabolites isolated from different extracts of Cassia tora have been reported to have therapeutic importance. 24 For example; anthraquinones from the seeds of Cassia tora is reported to show inhibitory activity on protein glycation and aldose reductase and antimicrobial activity 25 .…”

Section: Resultsmentioning

confidence: 99%

Untitled

2019

IJPSR

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Incidence of fungal infections is increasing at an alarming rate, presenting an enormous challenge to healthcare professionals. Despite advances in preventive, diagnostic, and therapeutic interventions, the invasive fungal infection causes significant morbidity and mortality in immunocompromised patients. An effective alternative to conventional synthetic antifungal agents can be the use of medicines from natural sources for treatment of fungal infections. The present study is based on a comparative evaluation of preliminary phytochemical screening and in-vitro antimicrobial activity of petroleum ether and ethanolic extracts of Cassia tora seeds and leaves. Phytochemical screening revealed the presence of carbohydrates in all four extracts while anthraquinones were found in ethanolic extract of leaves and seeds. The in-vitro antimicrobial assay was performed by agar well diffusion method. Each of the extracts was screened for antimicrobial activity against Candida albicans, Staphylococcus aureus, and Escherichia coli. Ethanolic extract of leaves showed significant antimicrobial activity. The MIC of ethanolic extract of leaves was found to be 100 mg/ml, 75 mg/ml and 50 mg/ml against Candida albicans, Staphylococcus aureus, and Escherichia coli respectively. Microspheres were prepared as a topical formulation using an ethanolic extract of leaves and evaluated. Particle size, entrapment efficiency of the optimized batch was found to be 65.34 µm and 82.91% respectively. In-vitro diffusion studies resulted in the sustained release of the developed formulation as compared to the marketed topical formulation.

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Section: Resultsmentioning

confidence: 99%

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2019

IJPSR

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“…The leaves were used in traditional systems of medicine for eye ailments and are a good source of antioxidant secondary metabolites. Studies have reported the presence of many polyphenolic compounds such as anthraquinones, anthocyanocides, flavonoids, sterols and terpenoids in the leaves of cassia tora (Sarwa et al, 2014) and HPLC analysis of cassia tora leaves (Supplementary data) indicated the presence of chrysophanol, the marker compound of the plant. Studies have shown that chrysophanol has free radical scavenging properties and reduced the oxidative stress in experimental animals (Rani et al, 2010) and no reports are available on the anticataractogenic effect of chrysophanol till to date.…”

Section: Discussionmentioning

confidence: 96%

Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups

Vasudevan

Abraham

2016

Journal of Ethnopharmacology

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“…The seed of charota resembles a coffee seed, therefore also known as wild coffee in India. Some other vernacular name is Foetida cassia, Ktanta, and chakaramarda in Indian languages [3]. Cassia tora regarded as safe for human consumption and used in the food industry for many years.…”

Section: Introductionmentioning

confidence: 99%

Charota (Cassia tora) Gum: A Potential Element as Suspending Agent, An Investigation of Suitability forDevelopment of Paracetamol Suspension

Sarwa¹,

Vishwakarma²,

Suryawanshi³

et al. 2022

IGJPS

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Background: Charota (Cassia tora)gum is well reported as an additivefor food product and generally recognized as safe” (GRAS). It is obtained from the seedof the herbaceousplantsof the Caesalpiniaceaefamily. The plant's seedcontainsgluco-mannose polysaccharides, which swell in water and form a colloidaldispersion with increasing viscosity.This property of the gum was exploredto use as a suspending agent for the preparation ofparacetamolsuspension. Result: In the present investigation, charota gum was extracted from the plant and used as a suspending agent in a range of 2-4% w/v in preparation of paracetamol suspension(5% w/v). The investigation has beenperformed comparedwith gum acacia, tragacanth,and gelatin at a similar range of 2-4% w/v.The parameters like sedimentation profile, rheological studies, redispersibility, pH, anddissolution rate were determinedtoevaluatesuspending abilityof Cassia toragum. Conclusion: A comparative datawith other gum reported a higher viscosity and lowest zeta potential for the suspension prepared with Charota gum. At different concentrations, itshowed better suspending ability and redispersibility compare, and it was stable throughout the storage period of 6 weeks. The study's dataconclude that charota gum produced flocculated suspension,redispersedintheleast no of shakespost sedimentation.©2022iGlobal Research and PublishingFoundation. All rights reserved.Cite this article as:Sarwa, K.K.; Vishwakarma, P.K.; Suryawanshi, V.K.; Uraon, D.;Sao, M.Charota (Cassia tora) Gum: A Potential Element as Suspending Agent, An Investigation of Suitability For Development of Paracetamol Suspension.Indo Global J. Pharm. Sci., 2022; 12:228-236.

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Phytochemical and Biological Potential of Cassia tora Linn.

Cited by 7 publications

References 54 publications

Untitled

Untitled

Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups

Charota (Cassia tora) Gum: A Potential Element as Suspending Agent, An Investigation of Suitability forDevelopment of Paracetamol Suspension

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