Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups

Vasudevan, Sreelakshmi; Abraham, Annie

doi:10.1016/j.jep.2015.12.012

Cited by 12 publications

(8 citation statements)

References 38 publications

(32 reference statements)

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“…This results in lens epithelial cell apoptosis and connexin modifications, the hall mark of cataractogenesis [16]. We previously reported the preventive potential of an edible plant Cassia tora in alleviating oxidative stress induced cataract on neonatal rats, and identified a flavonoid (kaempferol) and two anthraquinones (chrysophanol and emodin) from its leaves [17][18][19].…”

mentioning

confidence: 99%

Evaluation of the Drug-like Properties of Kaempferol, Chrysophanol and Emodin and their Interactions with EGFR Tyrosine Kinase - An in silico Approach

Vasudevan

Raj

Abraham

2017

Natural Product Communications

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In this study, a molecular docking was performed on EGFR tyrosine kinase with plant phenolic compounds kaempferol, chrysophanol and emodin; identified from Cassia tora, an edible plant employed for eye diseases traditionally. The results illustrated that all the compounds have strong binding abilities with epidermal growth factor receptor and validated the reported anticataractogenic potential of C. tora leaves. Further, the compounds also satisfied the criteria for being a drug through its structural features. Taken together, it was proposed that the compounds; kaempferol, chrysophanol and emodin might be helpful for further drug design and development and could be employed as efficient lead compounds in ophthalmic drug formulations.

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confidence: 99%

Evaluation of the Drug-like Properties of Kaempferol, Chrysophanol and Emodin and their Interactions with EGFR Tyrosine Kinase - An in silico Approach

Vasudevan

Raj

Abraham

2017

Natural Product Communications

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“…Cassia tora leaves delayed the onset and progression of cataract formation in neonatal rats. In addition to preserving the antioxidant defense system, lens morphology and the expression of lens crystallins, Cassia tora attenuated lipid peroxidation, compared to selenite-only treated lenses [235,236].…”

Section: Plant-derived Compounds and Herbal Remediesmentioning

confidence: 96%

Current Trends in the Pharmacotherapy of Cataracts

et al. 2020

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Cataracts, one of the leading causes of preventable blindness worldwide, refers to lens degradation that is characterized by clouding, with consequent blurry vision. As life expectancies improve, the number of people affected with cataracts is predicted to increase worldwide, especially in low-income nations with limited access to surgery. Although cataract surgery is considered safe, it is associated with some complications such as retinal detachment, warranting a search for cheap, pharmacological alternatives to the management of this ocular disease. The lens is richly endowed with a complex system of non-enzymatic and enzymatic antioxidants which scavenge reactive oxygen species to preserve lens proteins. Depletion and/or failure in this primary antioxidant defense system contributes to the damage observed in lenticular molecules and their repair mechanisms, ultimately causing cataracts. Several attempts have been made to counteract experimentally induced cataract using in vitro, ex vivo, and in vivo techniques. The majority of the anti-cataract compounds tested, including plant extracts and naturally-occurring compounds, lies in their antioxidant and/or free radical scavenging and/or anti-inflammatory propensity. In addition to providing an overview of the pathophysiology of cataracts, this review focuses on the role of various categories of natural and synthetic compounds on experimentally-induced cataracts.

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“…The identification of compounds by ESI-MS is based on the comparison with standards from a library of plant phenolics (Figures S1 and S2 ) (Sreelakshmi & Abraham 2016b ). The present work is an extension of our previous studies on the attenuation of cataract pathology by reducing protein and lipid modifications by Cassia tora leaves on oxidative stress cataract models (Sreelakshmi & Abraham 2016a , 2016b , 2016c ). The current study is designed to evaluate the mechanism of anti-cataractogenic effect of edible Cassia tora leaves on selenite-induced animal models by focusing on membrane integrity, energy metabolism, proteolysis and ubiquitin-proteasome pathway in the lens.…”

Section: Introductionmentioning

confidence: 71%

Protective effects of Cassia tora leaves in experimental cataract by modulating intracellular communication, membrane co-transporters, energy metabolism and the ubiquitin-proteasome pathway

Sreelakshmi

Abraham

2017

Pharmaceutical Biology

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Context: Cataract is the clouding of eye lens which causes impairment in vision and accounts for the leading factor of global blindness. Functional food-based prevention of cataract finds application in vision research because of its availability and easy access to all classes of the society. Cassia tora Linn. (Caesalpinaceae) is an edible plant mentioned in the traditional systems of medicine for whole body health, especially to the eyes.Objective: The present study evaluates the potential of ethyl acetate fraction of Cassia tora leaves (ECT) on experimental cataract.Materials and methods: Cataract was induced by a single subcutaneous injection of sodium selenite (4 μg/g body weight) on 10th day. ECT was supplemented orally from 8th day up to 12th day at a concentration of 5 μg/g body weight and marker parameters were evaluated after 30 days.Results: The production of MPO and the activation of calpain were reduced 52.17% and 36.67% by ECT in lens tissue, respectively. It modulated the energy status by significantly increasing the activity of CCO 1 (55.56%) and ATP production (41.88%). ECT maintained the ionic balance in the lens by reducing the level of sodium (50%) and increasing the level of potassium (42.5%). It also reduced cell junction modifications and preserved a functional ubiquitin-proteasome pathway.Discussion and conclusion: The results reinforce the growing attention on wild plant food resources for preventive protection against cataract. The data suggest the value of Cassia tora leaves as a functional food for ameliorating cataract pathology.

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Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups

Cited by 12 publications

References 38 publications

Evaluation of the Drug-like Properties of Kaempferol, Chrysophanol and Emodin and their Interactions with EGFR Tyrosine Kinase - An in silico Approach

Evaluation of the Drug-like Properties of Kaempferol, Chrysophanol and Emodin and their Interactions with EGFR Tyrosine Kinase - An in silico Approach

Current Trends in the Pharmacotherapy of Cataracts

Protective effects of Cassia tora leaves in experimental cataract by modulating intracellular communication, membrane co-transporters, energy metabolism and the ubiquitin-proteasome pathway

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