Phytochemical analysis, toxicity profile, and hemomodulatory properties of Annona muricata (Soursop)

Agu, Kingsley Chukwunonso; Okolie, Ngozi Paulinus; Eze, Ikechi G.; Anionye, J. Chukwudi; Falodun, Abiodun

doi:10.4103/1110-1067.206431

Cited by 22 publications

(23 citation statements)

References 2 publications

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“…This research was able to identify and established that Annona muricata possesses potent antioxidant properties. The observations in this study on the antioxidant potentials of Annona muricata could provide a mechanistic explanation of its reported ethnomedicinal importance (Agu, Okolie, Eze, et al., ; Agu, Okolie, Falodun, et al., ; Ahalya et al., ; Fang et al., ; Gupta et al., ; Okolie et al., ; Rupprecht et al., ; Vit et al., ). It is also expected that the data and findings from this research will provide a base‐line information for researchers who have reported possible links of antioxidant properties of Annona muricata with antineoplastic, wound healing, antihyperlipidemic, antiplasmodial, antileishmanial, etc.…”

Section: Discussionmentioning

confidence: 54%

“…The antioxidant data obtained were correlated with the phytochemical contents of the fractions (Agu, Okolie, Eze et al, ) using the Pearson's correlation (r). Some of the tests were also extrapolated to obtain 50 % inhibitory concentrations (IC 50 ).…”

Section: Resultsmentioning

confidence: 99%

“…Annona muricata has been attributed numerous health benefits most of which have been linked to its antioxidant potentials (Agu, Okolie, Eze, Anionye, & Falodun, ; Agu, Okolie, Falodun, et al., ; Ahalya, Shankar, & Kiranmayi, ; Baskar, Rajeswari, & Kumar, ; Chao‐Ming et al., ; Gupta, Pandey, Shah, Yadav, & Seth, ; Okolie, Agu, & Eze, ; Rupprecht, Hui, & Mc Laughlin, ). The antioxidant properties of the plant have been attributed to some of its phytochemicals and phytoconstituents (Agu, Okolie, Eze, et al., ; Agu, Okolie, Falodun, et al., ; Baskar et al., ; Gupta et al., 2011; Okolie et al., ; Vit, Santiago y, & Pérez‐Pérez, ). Thus, this formed the basis on which this research was designed and carried out.…”

Section: Introductionmentioning

confidence: 99%

“…It is a shrubby plant located majorly in the rain forest regions of Nigeria, where it is used locally for several ethnomedicinal purposes—as a laxative and purgative, wound healing, etc. The health benefits of this plant have been attributed to their unique phytochemical composition (Agu, Okolie, Eze, et al., ; Agu, Okolie, Falodun, et al., ; Okolie et al., ; Okwu & Omodamiro, ; ; Vit et al., ). Many bioactive compounds and phytochemicals, majorly the annonaceous acetogenins and essential oils, have been isolated and elucidated from A. muricata (Agu, Okolie, Falodun, et al., ; Gleye, Laurensa, Laprevoteb, Seranib, & Hocquemiller, ) and its many uses in natural medicine have been validated by scientific researches (Weniger et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…Agu, Okolie, Eze, et al. () reported the presence of alkaloids, flavonoids, and phenols in high quantities especially in the fruit pulp and leaf. They also reported the possible hemomodulatory properties of the plant.…”

Section: Introductionmentioning

confidence: 99%

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Proximate composition, phytochemical analysis, and in vitro antioxidant potentials of extracts of Annona muricata (Soursop)

Agu

Okolie

2017

Food Science & Nutrition

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Numerous bioactive compounds and phytochemicals have been reported to be present Annona muricata (Soursop). Some of these chemical compounds have been linked to the ethnomedicinal properties of the plant and its antioxidant properties. The aim of this study was to assess the proximate composition, phytochemical constituents and in vitro antioxidant properties of A. muricata using standard biochemical procedures. The defatted Annona muricata crude methanolic extracts of the different parts of the plant were used for the estimation of proximate composition and phytochemical screening. The crude methanolic extracts of the different parts of the plant were also fractionated using solvent–solvent partitioning. Petroleum ether, chloroform, ethyl acetate, methanol, and methanol‐water (90:10) were the solvents used for the fractionation. The different fractions obtained were then used to perform in vitro antioxidant analyses including, 1, 1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging ability, ferric reducing properties, and hydroxyl radical scavenging ability. The leaf methanolic extract had a higher lipid content, whereas its chloroform fraction demonstrated a better ability to quench DPPH free radical. The root‐bark methanol‐water, leaf methanol, fruit pulp chloroform, and leaf petroleum ether fractions demonstrated potent ferric reducing properties. The leaf and stem‐bark petroleum ether fractions demonstrated better hydroxyl‐free radical scavenging abilities. The leaf and fruit pulp of Annona muricata have a very potent antioxidant ability compared to the other parts of the plant. This can be associated with the rich phytochemicals and other phytoconstituents like phenols, flavonoids, alkaloids, and essential lipids, etc. Significant correlations were observed between the antioxidant status and phytochemicals present. These results thus suggest that some of the reported ethnomedicinal properties of this plant could be due to its antioxidant potentials.

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