Phytochemical Analysis, Standardization and Cytotoxic Activity of <i>Curcuma aureginosa</i> Extract in Human Breast Cancer (MCF-7) Cell Line

Isrul, Muhammad; Juliansyah, Risky; Saleh, Ahmad; Yuliastri, Wa Ode; Pusmarani, Jastria; Himaniarwati, None; Maulidina, Wa Ode Wahyuni

doi:10.5958/0974-360x.2019.00329.9

Cited by 8 publications

(2 citation statements)

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“…The value of IC 50 is expressed from the relationship between the extract concentration curve (x-axis) and the inhibition (%) curve (y-axis) with the linear regression analysis. According to the National Cancer Institute, the IC 50 value is the concentration of the extract used to inhibit the growth of 50% of cancer cells (Isrul et al, 2019). Categorization of IC 50 value if the IC 50 value < 4 ppm is highly cytotoxic, 4 ppm ≤ IC 50 value < 20 ppm is moderately cytotoxic, 20 ppm ≤ IC 50 value < 100 ppm is weakly cytotoxic, and IC 50 ≥ 100 ppm is not cytotoxic (Mutiah, 2020).…”

Section: Anticancer Activity Of Simpor Leaf Extract With Mtt Assaymentioning

confidence: 99%

Simpor leaf extract- (Dillenia suffruticosa Martelli) induced apoptosis of the MCF-7 and HepG2 cell lines

Rahayu¹,

Chang²,

Supiyani³

et al. 2023

J App Pharm Sc

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Cancer is a malignant tumor with characteristics of uncontrolled cell growth, poor metastasis, leading to the dysfunction of organs and death of patients. Many efforts have been made, including the exploration of natural products. The purpose of this study was to determine the cytotoxicity of the Dillenia suffruticosa leaf extract against the cell lines MCF-7 and HepG2. The method used is an experimental research design with a completely randomized design. The treatment group consisted of the leaf extract of 500, 1,000, 2,000, 5,000, and 9,000 ppm for the brine shrimp lethality test (BSLT). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) test used 10, 15, 20, 25, and 50 ppm concentrations and control (without extract). The data on the BSLT test was determined by analyzing the lethal concentration 50 (LC 50 ) value using the probit analysis, while the MTT test was determined by analyzing the IC 50 and analysis of variance test. The BSLT test results showed an LC 50 value of 5,221 ppm, which means that the leaf extract is not toxic. Simpor leaf extract at 25 ppm with IC50 of 88.52 was seen as the best concentration for liver cancer treatment. It can be concluded that D. suffruticosa shows cytotoxicity against the cell lines MCF-7 and HepG2 and can be used as a candidate for breast and liver cancer treatment.

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Section: Anticancer Activity Of Simpor Leaf Extract With Mtt Assaymentioning

confidence: 99%

Simpor leaf extract- (Dillenia suffruticosa Martelli) induced apoptosis of the MCF-7 and HepG2 cell lines

Rahayu¹,

Chang²,

Supiyani³

et al. 2023

J App Pharm Sc

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show abstract

“…Currently, breast and lung cancer are the two most common forms of human cancer which led to a relatively high mortality rate. There have been many studies on evaluating the pharmacological effects of plant extract on these two cancers [20][21][22][23] . However, there have been a limited number of studies on the impact of A. setaceus dry extract on cancer cell lines.…”

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confidence: 99%

Anti-cancer activity of dry extract of Anoectochilus setaceus blume against BT474 breast cancer cell line and A549 lung cancer cell line

Chac¹,

Thinh²,

Yến³

2021

Research Journal of Pharmacy and Technology

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Breast and lung cancer are the two most common forms of human cancer, which also have a relatively high mortality rate, particularly lung cancer. It is urgent and essential to discover pharmaceutical products that can prevent the growth of cancer cells in general, especially breast and lung cancer. Anoectochilus setaceus Blume has been used in several pharmacological applications and has a long history of medicinal use in traditional medicine. This research was conducted to evaluate the anti-cancer potential of A. setaceus dry extract, which was created by the fermentation method, against the BT474 breast cancer cell line and the A549 lung cancer cell line. High-performance liquid chromatography indicated that A. setaceus dry extract contains three pharmacological compounds, including quercetin, isorhamnetin and ferulic acid. Meanwhile, MTT assay showed that A. setaceus dry extract had quite a strong cytotoxic activity against the BT474 breast cancer cell line and the A549 lung cancer cell line with IC50 value of 5.45 µg/mL and 14.85 µg/mL respectively. These results also concluded that A. setaceus has good medicinal effects, especially on the treatment of breast and lung cancer.

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Natural Approaches to Whiten the Dental Enamel Surface Versus the Conventional Approaches

Bishbishy

Hamza

Taher

et al. 2021

RJPT

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To the public majority, teeth whitening and appearance is crucial and affect their esthetic qualities. Despite that, in many cultures, home remedies been employed for teeth whitening, there is dearth of solid scientific evidence regarding their effectiveness. This study was conducted aiming to characterize and formulate some of these remedies and to compare their teeth whitening effect to conventional teeth whitening toothpaste after tooth brushing at one and six months’ intervals. Cocos nucifera L. (Coconut) oil, along with the alcoholic extracts of Salvia officinalis L. (Sage) herb, Curcuma longa L. (Turmeric) rhizomes, Psidium guajava L. (Guava) leaves, Citrus limon L. (Lemon) fruits peels and Fragaria ananassa Duchesne (Strawberry) fruits were separately used to prepare toothpastes. The oil and extracts were subjected to GC and HPLC-MS/MS respectively. The formulated toothpastes were of different colors, smooth in nature, foamability around 10, pH-8.2 and extrudability 95%. The best formulations were of S. officinalis (SO), C. longa (CL) and C. nucifera (CN), therefore, their corresponding toothpastes were further investigated. 20 extracted premolars were selected based on orthodontic reasons, randomly distributed into four groups and evaluated using CIELAB measurement system at base line before brushing T0 and after brushing for one month T1 and six months T2. SO showed color changes ( E > 3.3) which can be easily observed clinically. Therefore, it could be concluded that SO toothpaste was effective in changing the color of dental enamel with results comparable to those of the conventional toothpaste.

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Phytochemical Analysis, Standardization and Cytotoxic Activity of Curcuma aureginosa Extract in Human Breast Cancer (MCF-7) Cell Line

Cited by 8 publications

References 0 publications

Simpor leaf extract- (Dillenia suffruticosa Martelli) induced apoptosis of the MCF-7 and HepG2 cell lines

Simpor leaf extract- (Dillenia suffruticosa Martelli) induced apoptosis of the MCF-7 and HepG2 cell lines

Anti-cancer activity of dry extract of Anoectochilus setaceus blume against BT474 breast cancer cell line and A549 lung cancer cell line

Natural Approaches to Whiten the Dental Enamel Surface Versus the Conventional Approaches

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