Phytochemical Analysis of the Desert Date Balanites aegyptiaca

Abdel-Farid, Ibrahim B.; El‐Sayed, Magdi A.

doi:10.21608/ejbo.2020.37920.1533

Cited by 4 publications

(4 citation statements)

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“…Phenotypic and genotypic variations have been reported among B. aegyptiaca plants collected from different locations, which affected their chemical composition and biological activities [ 14 ]. Differences in the phytochemical composition including oil, protein, and some minerals together with the antioxidant activity of fruits collected from different B. aegyptiaca trees were reported by several authors, such as Abdel-Farid and El-Sayed [ 15 ] and Abdelaziz et al [ 4 ]. In this context, considerable variation in the phytochemical profile of B. aegyptiaca methanolic fruit extract is noticeable between the publications.…”

Section: Discussionmentioning

confidence: 99%

“…Literature data show considerable variation in bioactive compounds and biological activities of B. aegyptiaca of various origins based on geographical and environmental conditions [ 14 ]. Differences in phytochemical composition, including oil, protein, and some minerals, together with the antioxidant activity of fruits collected from different trees of B. aegyptiaca, were reported by several authors such as Abdel-Farid and El-Sayed [ 15 ] and Abdelaziz et al [ 4 ]. According to several studies, B. aegyptiaca seeds contain approximately 38–57% fats with palmitic and oleic acids being the prevalent fatty acids estimated to be around 40% of seed oil [ 1 , 3 , 7 , 8 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 98%

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Investigation of Potential In Vitro Anticancer and Antimicrobial Activities of Balanites aegyptiaca (L.) Delile Fruit Extract and Its Phytochemical Components

Ibrahim

Al‐Qurashi

Asiry

et al. 2022

Plants

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The therapeutic importance of Balanites aegyptiaca in folk medicine for the treatment of several common human diseases has led researchers to conduct phytochemical and pharmacological studies on extracts from various parts of the plant. In the current study, the phytochemical composition of the B. aegyptiaca methanolic fruit extract was characterized, and its antimicrobial activity was evaluated together with the cytotoxic activity against MCF-7, PC-3, and Caco-2, compared with normal Vero cells. Further, its effects on cell cycle arrest, apoptosis induction and expression of apoptosis-related genes were assessed. The phytochemical screening revealed the presence of fatty acids and their esters in addition to phytosterols, steroid derivatives, and bioflavonoid glycosides with oleic and palmitic acids being the prevalent components (24.12 and 21.56%, respectively). The results showed considerable cytotoxic activity of the extract against the three cancer cell lines (MCF-7, PC-3, and Caco-2) with a selectivity index ranging from 5.07 to 6.52. This effect was further confirmed with the accompanied increased total apoptosis of treated PC-3 cells (19.22% of the total number of cells) compared to the control cells (0.64% of the total number of cells) with cell cycle arrest at G1 phase and the increased transcription of pro-apoptotic genes including P53 (3.69) and BAX (3.33) expressed as fold change (2^ ΔΔCT). The calculated minimum inhibitory concentration (MIC) was similar (62.5 µg/mL) against the three tested bacterial strains (Acinetobacter johnsonii, Serratia marcescens and Agrobacterium tumefaciens), while it was higher than 1000 µg/mL for the fungal species (Rhizoctonia solani, Penicillium italicum, and Fusarium oxysporium). Our findings suggest a promising anticancer activity for B. aegyptiaca, which paves the way for more detailed future studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Investigation of Potential In Vitro Anticancer and Antimicrobial Activities of Balanites aegyptiaca (L.) Delile Fruit Extract and Its Phytochemical Components

Ibrahim

Al‐Qurashi

Asiry

et al. 2022

Plants

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“…Scientific researchers are encouraged to look for natural alternatives, examining their biological activities and purchasing their modes of action for the benefit of humanity due to the rapid development in ailments and the heavy utilization of synthetic pharmaceuticals. Because plant-derived chemicals have a variety of biological functions and action mechanisms (Larçin et al, 2015;Slima et al, 2021;Mokhtar et al, 2023), there have been some investigations on the metabolites found in seeds, grains, fruits, legumes, roots, rhizomes, and green vegetative parts of commercial plants that have been extracted using water or chemicals (Abdel-Farid & El-Sayed, 2021;Elwakf et al, 2022;Gaballa et al, 2022;Soliman et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics and Biological Activities of Residual Parts from some Egyptian Green Vegetables

et al. 2023

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Egyptian Journal of Botany http://ejbo.journals.ekb.eg/ 48 S EARCHING for natural alternatives to replace the synthetic pharmaceuticals, investigations for active metabolites ith biological activities in different plant parts (seeds, grains, fruits, peels of fruits, roots, rhizomes and green vegetables) are always of great importance and interest. As an example of the nutritional leafy vegetables, Corchorus olitorius and Portulaca oleracea are widely distributed and eaten by many countries. These plants constitute the material of interest in this study. Extraction of the leafy vegetables was carried out by methylene chloride: methanol mixture (2:1 v/v). The extract was subjected to analyse their antioxidant and anticancer efficiencies. Three methods were used for antioxidant activity determination including DPPH (2,2-diphenylpicrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and KMnO 4 (potassium permanganate). P. oleracea extract showed the greatest antioxidant activity by the three methods (86.55, 82.75 and 97.62%, respectively) compared to both C. olitorius (75.98, 57.02 and 34.98% respectively) and standard ascorbic acids (76.42, 73.93 and 99.09% respectively) at 100 µg/ml. C. olitorius extract exhibited highest cytotoxicity against HepG2 (Human liver cancer cell line) compared to both P. oleracea and the anticancer drug Doxorubicin. Gas chromatography/Mass spectroscopic analysis revealed that the leafy vegetable extracts contain 15 and 18 phytochemical compounds (in P. oleracea and C. olitorius, respectively) and the monounsaturated fatty acid oleic acid was the major constituent with 42-44.69%. The active groups in the phytochemicals were analyzed by FTIR technique. From this study, we recommend P. oleracea extract to be used as source of antioxidant agents, while C. olitorius extract can be considered as an anticancer active vegetable.

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“…Balanites aegyptiaca Delile (L.) (Family: Balanitaceae) is commonly known as the desert date, is a spiny tree that grows up to 10 meters tall and is found in Africa and South Asia. B. aegyptiaca grows in Western and Eastern deserts of Egypt and at the borders between Egypt and Sudan (Abdel-Farid and El-Sayed, 2021). B. aegyptiaca fruit is reported to have a wide variety of compounds with different biological and pharmacological effects such as anti-inflammatory, antioxidant, cytotoxic and antimicrobial activities (Chothani and Vaghasiya, 2011).…”

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confidence: 99%

Assessment of Phytochemical, Antioxidant and Antibacterial Activity of Balanites Aegyptiaca and Curcuma Longa against Some Bacterial Pathogens Isolated from Dairy Cow Infected with Mastitis

Sedky¹,

Mohamed²,

Fouad³

et al. 2021

AAVS

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Bovine mastitis is very important disease threatening the dairy industry and animal wealth globally, resulting in great economic losses. The present work was aimed to assess the phytochemical components, antioxidant activity and the antibacterial effectiveness of Balanites aegyptiaca fruits (BAF) and Curcuma longa powder (CLP) extracts. A total of 287 quarter milk samples were collected from dairy cows raised in four different governorates of Egypt; 95 from clinical mastitis, 37 from subclinical mastitis and 155 from normal milk samples. The isolates from milk samples were identified and differentiated by microbiological cultures, colony morphology, hemolytic activity of the colony, Gram's stain and biochemical tests. Antibacterial activity of the aqueous extract of BAF (AE-BAF) and ethanolic extract of CLP (EE-CLP) at different concentrations were investigated against Gram-positive and Gram-negative bacteria isolated from clinical and subclinical mastitic cows using agar well diffusion technique. The isolated bacteria from collected milk samples were Staphylococcus aureus (30.30%), Escherichia coli (28.03%), Streptococcus agalactiae (19.70%), Salmonella spp. (10.60%), Bacillus subtilis (6.06%), Klebsiella pneumoniae (3.03%) and Pseudomonas aeruginosa (2.27%). Preliminary phytochemical screening of AE-BAF indicated the presence of flavonoids, saponins, tannins, phenols, carbohydrate, cardiac glycoside, terpenoids and steroids. Except the cardiac glycoside, the EE-CLP contains the same components. The antioxidant efficacy of the tested plant extracts was evaluated by using free radical scavenging assay method. The AE-BAF and EE-CLP posses 86.6% and 85.9% free radical scavenging activity with 1.5 and 0.125 mg /ml concentrations, respectively. The AE-BAF possess significant antibacterial activity at 400 and 800 mg/ml against all isolates, except K. pneumoniae which was not suppressed at the 400 mg/ml concentration. The significant (P ≤ 0.05) antibacterial activities of EE-CLP were observed at 20 and 50 mg/ml concentrations. It could be concluded that AE-BAF and EE-CLP exhibited potent in-vitro antibacterial activities, thus justifying their application in treatment of clinical cases of bovine mastitis.

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Phytochemical Analysis of the Desert Date Balanites aegyptiaca

Cited by 4 publications

References 20 publications

Investigation of Potential In Vitro Anticancer and Antimicrobial Activities of Balanites aegyptiaca (L.) Delile Fruit Extract and Its Phytochemical Components

Investigation of Potential In Vitro Anticancer and Antimicrobial Activities of Balanites aegyptiaca (L.) Delile Fruit Extract and Its Phytochemical Components

Metabolomics and Biological Activities of Residual Parts from some Egyptian Green Vegetables

Assessment of Phytochemical, Antioxidant and Antibacterial Activity of Balanites Aegyptiaca and Curcuma Longa against Some Bacterial Pathogens Isolated from Dairy Cow Infected with Mastitis

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