Phytochemical Analysis, Antioxidant and Antimicrobial Activities of Three Samples of Dried Figs (Ficus Carica L.) From the Region of Mascara

Abstract

Ficus carica L. have always been known by their power to cure various diseases. This study aims to evaluate the antioxidant activity of twelve different extracts of three samples of dried figs. First, the extracts were tested for their polyphenolic, flavonoid and tannin contents by the Folin–Ciocalteu, the aluminium trichloride and vanillin methods and high-performance liquid chromatography (HPLC) for more characterisation. The antioxidant activity was performed by using thre different methods; the 2,2-diphenyl-2-picrylhydrazyl (DPPH), Ferric reducing antioxidant power (FRAP) and total antioxidant capacity (TAC). The results showed that the methanolic extract of Sidi Bendjebbar sample presented a higher TPC value (458 mg GAE /g) while the acetonic and aqueous extracts of El-Keurt presented a higher values of TFC and CTC. In other hand, the methanol extract of El-Keurt sample exhibited the highest antioxidant capacity with an IC50 of 0.078 mg/ml. The antimicrobial activity of the extracts against various Gram positive and Gram negative bacteria was screened by the inhibition zone using the disc and diffusion assay, minimal inhibition concentration (MIC) by micro-well method allonwing to calculate the fractional inhibitory concentration (FIC). The ethanolic extracts of the two samples El-Keurt and Sidi Bendjebbar were the most effective extracts being able to inhibit the growth of the majority of the strains tested. Our study supported the use of these fruit as supplements for nutrient deficiencies and for combating diseases associated with oxydative damage or some microbial infection for better drug alternatives.

Phytochemical Profile and Biological Activities of Ficus carica Fruit’s Extract

“…It can be noticed that g peel showed higher DPPH reducing potential compared to the pulp. Similar results have been reported by Benmaghnia et al [32], from dried gs extracts using 4 types of solvents (50% acetone, 70% ethanol, 80% methanol, and water). The ethanolic extract showed the highest DPPH reducing activity (65.1-88.1%), followed by methanolic extract (78.6-84.6%), acetonic extract (78.2-81.3%), and aqueous extract (73.1-80.6%).…”

“…The results revealed that high temperature (80°C) and solvent with higher ethanol concentration (80%) were more effective to extract TFC (2.5 mg/g) compared to 50% ethanol (0.44 mg/g), and lower temperature (25°C). Benmaghnia et al [32] compared four solvents (50% acetone, 70% ethanol, 80% methanol, and water) to evaluate their e ciency to extract phytochemicals from dried gs. Acetone was most e cient to extract TFC (228.22 mg/100g) compared to methanolic extract (38.8 mg/100g).…”

Xanthine Oxidase Inhibitory Activity of Ethanolic Extract of Ficus Carica Fruit

“…Ficus carica dried fruit was selected due to its antioxidant properties and possession of high content of flavonoids. 20 Moreover, due to high content of flavonoids and the ability to inhibit…”

Antimicrobial Effect of Ficus carica on Nosocomial Bacterial Infections

“…This diameter was 11 mm in K. pneumoniae, 10 mm in E. coli, and 15 mm in S. typhimurium. A study entitled "Phytochemical analysis, antioxidants and antimicrobial activity of three samples of dried F. carica from the region of Mascara (Western Algeria)" was conducted by Benmaghnia et al (12). The results indicated that ethanol extract could inhibit growth of most strains, and the inhibition zone diameter was 10 mm in S. aureus, 0.8 mm in P. aeruginosa, 10 mm in E. coli, and 10 mm in P. mirabilis.…”