Phytochemical analysis and assessment of antioxidant and antimicrobial activities of some medicinal plant species from Egyptian flora

Al-Tohamy, Rania; Ali, Sameh S.; Saad‐Allah, Khalil M.; Fareed, Mervat F.; Ali, Asmaa; El-Badry, Anwer; El-Zawawy, Nessma; Wu, Jian; Sun, Jianzhong; Mao, Guanghua; Rupani, Parveen Fatemeh

doi:10.1016/j.jab.2018.08.001

Cited by 54 publications

(26 citation statements)

References 67 publications

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“…The second plant in this work is Varthemia candicans, a member of the family Asteraceae, which has been reported to be a competent treatment for some diseases in folk medicine. Phytochemical constituents of V. candicans showed that it contains many prophylactic components such as sesquiterpenes, sesquiterpene-lactone derivatives, polymethoxylated flavonoids, and coumarins [14]. Plant sesquiterpenes are known to have diverse biological and therapeutical activities, including antineoplastic agents.…”

Section: Introductionmentioning

confidence: 99%

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

Diab

Donia

Saad‐Allah

2021

Beni-Suef Univ J Basic Appl Sci

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Background Natural products from plants are very safe as compared to synthetic ones, so the aim of this study was to assess the in vitro antioxidant and antitumor activities of the ethanolic extracts of four Egyptian wild plant species (Varthemia candicans, Peganum harmala, Suaeda vermiculata, and Conyza dioscoridis), as well as polyphenols and flavonoid contents with gas chromatography–mass spectrometry (GC-MS). The antioxidant activity of the four plant extracts was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) to determine 50% inhibition of DPPH radical scavenging activity and reducing power by phosphomolybdate assay. In addition, the chemical composition of the four sample extracts was investigated using GC-MS. The total phenolic and flavonoid levels were also determined. Then, the antitumor activity of the plant extracts against HepG2 cells was determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results The results showed that Varthemia candicans extract was the highest one regarding both polyphenols and flavonoid contents. Moreover, the extract of Suaeda vermiculata exhibited the lowest half maximum inhibitory concentration (IC50) against DPPH, thus indicating its highest effectiveness. All studied plant extracts decreased the viability of HepG2 cells, in a dose- and time-dependent manner, and the lowest IC50 was for Suaeda vermiculata. Conclusion The investigated plant extracts showed potent antioxidant and antitumor activities in vitro due to their phytochemical contents.

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Section: Introductionmentioning

confidence: 99%

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

Diab

Donia

Saad‐Allah

2021

Beni-Suef Univ J Basic Appl Sci

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“…It was also proved to have antimicrobial activity. Suaeda vermiculata was moreover demonstrated to be a novel source for the investigation of unused antioxidant and antimicrobial specialists that are possibly esteemed for nourishment and biomedical applications (Al-Tohamy et al, 2018). Our inquire about pointed to utilize both plants as characteristic sources of cancer prevention agents to overcome the oxidative stretch initiated by doxorubicin (chemotherapeutic medicine).…”

Section: Antimicrobial and Histological Data Effect Of Silybum Marianum And Suaeda Vermiculata Against Doxorubicin Induced Toxicity In Mamentioning

confidence: 98%

Antimicrobial and Histological Data Effect of Silybum marianum and Suaeda vermiculata Against Doxorubicin Induced Toxicity in Male Rats

Othman

Ali

2021

Asian Pac J Cancer Prev

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Objective: Silybum marianum and Suaeda vermiculata are popular plants wealthy in cancer prevention agents. There is no enough research on both plants since they are not available in many places. They are widely spread in Egypt. Methods: This research was performed to estimate their antimicrobial effect as well as their hepatoprotective effect against strong drugs inducing oxidative stress such as doxorubicin which may be a chemotherapeutic operator utilized to treat different sorts of cancer and demonstrated to be hepatotoxic medicate. Six bunches of male Wistar rats were utilized (control, Silybum marianum extricate, Suaeda vermiculata extricate, doxorubicin, Silybum marianum extricate additionally doxorubicin and Suaeda vermiculata extricate additionally doxorubicin). Results: Our data confirmed the effective antimicrobial effect of both plants and also the hepatoprotective effect against oxidative damage. Both plants are highly recommended as natural supplements by patients treated by different drugs inducing oxidative stress whereas; Milk thistle was proved to be stronger hepatoprotective herb.

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“…In addition, the roots of S. vermiculata exhibited strong anti-acetylcholinesterase activity. Al-Tohamy et al [15] indicated high antioxidant and antimicrobial activities of S. vermiculata methanolic extract. Therefore, due to the lack of data regarding the phytochemical composition and biological properties of different parts of Salsola vermiculata, the present research focused on phytochemical study and biological activity (α-glucosidase inhibitory and acetylcholinesterase enzyme activity) of different parts (roots, seeds, leaves, and owers) of S. vermiculata.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling and Inhibitory Properties of Different Parts of Salsola Vermiculata Towards Acetylcholinesterase and α-glucosidase

Mollaei

Farnia

Ghanavi

2021

Preprint

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Background: Herbal and natural medicines play significant roles in treatment of diseases and development of novel drugs. Salsola vermiculata is an annual plant which is broadly distributed in southwest of Asia, and is used for treatment of stomach disorders. Results: This present study aimed at identifying and comparing the metabolic profiles of different parts of Salsola vermiculata and to evaluate the inhibitory potential of their extracts and fractions towards acetylcholinesterase and α-glucosidase. LC-ESI-MS, GC, and GC-MS analytical methods were employed for metabolite profiling of the extracts, and their fractions. The α-glucosidase and acetylcholinesterase inhibitory activities of the samples were determined by microplate colorimetric methods. Based on results, 44 metabolites were identified in different parts of S. vermiculata. In roots, vanillic acid, rutin, salsoline, salsoline A, palmitic acid, oleic acid, linoleic acid, cumin aldehyde, and carvone; in seeds, vanillic acid, salsoline A, palmitic acid, oleic acid, linoleic acid, carvone, and β-caryophyllene; in leaves, gallic acid, vanillic acid, caffeic acid, rosmaric acid, rutin, quercetin, limonene, and carvone, and in flowers, gallic acid, vanillic acid, cinnamic acid, rosmaric acid, rutin, kaempferol, limonene, linalool, and carvone were recorded as the main components. According to the inhibitory activities results, the ethyl acetate fractions of leaves and the aqueous-acid fraction of roots displayed highest inhibitory activity towards acetylcholinesterase (IC50: 17.24 µg/mL), and α-glucosidase (IC50: 62.37 µg/mL), respectively. Conclusion: Finally, the leaves and roots of S. vermiculata are rich of phenolic and alkaloids compounds and the findings of this study depict them as a promising acetylcholinesterase and α-glucosidase inhibitors, and therefore, can be utilized for the development of new drugs.

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Phytochemical analysis and assessment of antioxidant and antimicrobial activities of some medicinal plant species from Egyptian flora

Cited by 54 publications

References 67 publications

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

Antimicrobial and Histological Data Effect of Silybum marianum and Suaeda vermiculata Against Doxorubicin Induced Toxicity in Male Rats

Metabolic Profiling and Inhibitory Properties of Different Parts of Salsola Vermiculata Towards Acetylcholinesterase and α-glucosidase

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