Antimicrobial and Histological Data Effect of Silybum marianum and Suaeda vermiculata Against Doxorubicin Induced Toxicity in Male Rats

Abstract

Objective: Silybum marianum and Suaeda vermiculata are popular plants wealthy in cancer prevention agents. There is no enough research on both plants since they are not available in many places. They are widely spread in Egypt. Methods: This research was performed to estimate their antimicrobial effect as well as their hepatoprotective effect against strong drugs inducing oxidative stress such as doxorubicin which may be a chemotherapeutic operator utilized to treat different sorts of cancer and demonstrated to be hepatotoxic medicate. Six bunches of male Wistar rats were utilized (control, Silybum marianum extricate, Suaeda vermiculata extricate, doxorubicin, Silybum marianum extricate additionally doxorubicin and Suaeda vermiculata extricate additionally doxorubicin). Results: Our data confirmed the effective antimicrobial effect of both plants and also the hepatoprotective effect against oxidative damage. Both plants are highly recommended as natural supplements by patients treated by different drugs inducing oxidative stress whereas; Milk thistle was proved to be stronger hepatoprotective herb.

Targeting the PI3K/pAKT/mTOR/NF‐κB/FOXO3a signaling pathway for suppressing the development of hepatocellular carcinoma in rats: Role of the natural remedic Suaeda vermiculata forssk

“…Suaeda vermiculata (SV) is a halophytic plant rich in antioxidant and antimicrobial constituents. 37 SVE was reported to treat respiratory diseases such as asthma, 48 has an antimicrobial effect 49 and treats viral diseases. 31 Mohammed SAA et al, demonstrated that SVE has no deleterious effects on kidney and liver enzymes, lipid profiles, or glucose, with only a mild lowering effect on triglyceride levels.…”

“…Suaeda vermiculata (SV) is a halophytic plant rich in antioxidant and antimicrobial constituents 37 . SVE was reported to treat respiratory diseases such as asthma, 48 has an antimicrobial effect 49 and treats viral diseases 31 .…”

“…27,34 The plant has been documented to exhibit supplementary bioactivities, including anti-inflammatory, antioxidant, antibacterial, antidiabetic, and analgesic characteristics. 32,36,37 It was previously stated that the aforementioned bioactivities acknowledge the rich content of phenolic acids and flavonoids in SVE, which in turn might be attributed to the tough environmental conditions, for example, high salinity, drought, and marsh environments, in which the plant grows. [38][39][40] It has been demonstrated that SVE contains flavonoids and phenolic acids using spectrophotometric and spectroscopic analysis.…”

“…They enhanced HepG‐2/ADR cell sensitivities towards the anticancer drug doxorubicin, a result that was linked to the plant's abundant flavonoids 27,34 . The plant has been documented to exhibit supplementary bioactivities, including anti‐inflammatory, antioxidant, antibacterial, antidiabetic, and analgesic characteristics 32,36,37 . It was previously stated that the aforementioned bioactivities acknowledge the rich content of phenolic acids and flavonoids in SVE, which in turn might be attributed to the tough environmental conditions, for example, high salinity, drought, and marsh environments, in which the plant grows 38–40 .…”