Physiology, Pharmacology, and Topography of Cholinergic Neocortical Oscillations In Vitro

Lukatch, Heath S.; MacIver, M Bruce

doi:10.1152/jn.1997.77.5.2427

Cited by 74 publications

(45 citation statements)

References 96 publications

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“…When the slices were perfused with 100 M carbachol and 10 M bicuculline, oscillations (4 -15 Hz) occurred spontaneously, and the activity appeared as spiral and other waves in the voltage-sensitive dye imaging. These activities lasted as long as the preparation was perfused with carbachol and bicuculline, similar to coronal slices (Lukatch and MacIver, 1997;Bao and Wu, 2003).…”

Section: Methodsmentioning

confidence: 72%

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Spiral Waves in Disinhibited Mammalian Neocortex

Huang¹,

Troy²,

Yang³

et al. 2004

J. Neurosci.

373

292

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Spiral waves are a basic feature of excitable systems. Although such waves have been observed in a variety of biological systems, they have not been observed in the mammalian cortex during neuronal activity. Here, we report stable rotating spiral waves in rat neocortical slices visualized by voltage-sensitive dye imaging. Tissue from the occipital cortex (visual) was sectioned parallel to cortical lamina to preserve horizontal connections in layers III-V (500-m-thick, ϳ4 ϫ 6 mm 2 ). In such tangential slices, excitation waves propagated in two dimensions during cholinergic oscillations. Spiral waves occurred spontaneously and alternated with plane, ring, and irregular waves. The rotation rate of the spirals was ϳ10 turns per second, and the rotation was linked to the oscillations in a one-cycle-one-rotation manner. A small (Ͻ128 m) phase singularity occurred at the center of the spirals, about which were observed oscillations of widely distributed phases. The phase singularity drifted slowly across the tissue (ϳ1 mm/10 turns). We introduced a computational model of a cortical layer that predicted and replicated many of the features of our experimental findings. We speculate that rotating spiral waves may provide a spatial framework to organize cortical oscillations.

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Section: Methodsmentioning

confidence: 72%

“…Oscillations of 4 -15 Hz developed in neocortical tissue when perfused with 100 M carbachol and 10 M bicuculline (Lukatch and MacIver, 1997). The oscillations were organized as epochs, each epoch containing 10 -50 cycles.…”

Section: Oscillation and Optical Signalsmentioning

confidence: 99%

Spiral Waves in Disinhibited Mammalian Neocortex

Huang¹,

Troy²,

Yang³

et al. 2004

J. Neurosci.

373

292

View full text Add to dashboard Cite

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“…Neocortical oscillations at ϳ10 Hz are observed in vivo and in brain slices under conditions of enhanced excitability (Silva et al, 1991;Flint and Connors, 1996;Lukatch and MacIver, 1997;Steriade et al, 1998b;Castro-Alamancos, 2000, 2006Castro-Alamancos and Rigas, 2002;Castro-Alamancos et al, 2007). Oscillations at 10 Hz occur while GABA receptors are blocked (Flint and Connors, 1996), suggesting that they are generated by the excitatory network.…”

Section: Implications For Epilepsymentioning

confidence: 99%

Conditional Bursting Enhances Resonant Firing in Neocortical Layer 2–3 Pyramidal Neurons

Higgs¹,

Spain²

2009

J. Neurosci.

156

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The frequency response properties of neurons are critical for signal transmission and control of network oscillations. At subthreshold membrane potential, some neurons show resonance caused by voltage-gated channels. During action potential firing, resonance of the spike output may arise from subthreshold mechanisms and/or spike-dependent currents that cause afterhyperpolarizations (AHPs) and afterdepolarizations (ADPs). Layer 2-3 pyramidal neurons (L2-3 PNs) have a fast ADP that can trigger bursts. The present study investigated what stimuli elicit bursting in these cells and whether bursts transmit specific frequency components of the synaptic input, leading to resonance at particular frequencies. We found that two-spike bursts are triggered by step onsets, sine waves in two frequency bands, and noise. Using noise adjusted to elicit firing at ϳ10 Hz, we measured the gain for modulation of the time-varying firing rate as a function of stimulus frequency, finding a primary peak (7-16 Hz) and a high-frequency resonance (250 -450 Hz). Gain was also measured separately for single and burst spikes. For a given spike rate, bursts provided higher gain at the primary peak and lower gain at intermediate frequencies, sharpening the high-frequency resonance. Suppression of bursting using automated current feedback weakened the primary and high-frequency resonances. The primary resonance was also influenced by the SK channel-mediated medium AHP (mAHP), because the SK blocker apamin reduced the sharpness of the primary peak. Our results suggest that resonance in L2-3 PNs depends on burst firing and the mAHP. Bursting enhances resonance in two distinct frequency bands.

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“…C lass I interneurons may control burst duration, as they presumably inhibit pyramidal cells nearly synchronously with excitatory inputs. Even with GABA A receptors blocked, pyramidal cells are capable of firing in a bursting pattern, demonstrating that GABAergic interneurons promote but are not essential for burst initiation (Konopacki and Golebiewski, 1993;L ukatch and MacIver, 1997).…”

Section: The Role Of Interneurons In Carbachol Burst Generationmentioning

confidence: 99%

Functionally Distinct Groups of Interneurons Identified During Rhythmic Carbachol Oscillations in HippocampusIn Vitro

1998

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During distinct behavioral states, the hippocampus exhibits characteristic rhythmic electrical activity. Evidence in vivo suggests that both principal pyramidal cells and GABAergic interneurons participate in generating oscillations. We found that during rhythmic oscillations in area CA3, functionally distinct classes of interneurons could be identified, although all recorded interneurons had similar dendritic and axonal arbors. One group of interneurons was powerfully excited by CA3 pyramidal cells, whereas two other interneuron groups were relatively unaffected by pyramidal cell firing. One of these groups of interneurons was potently inhibited by other local interneurons during the pyramidal cell bursts. Our findings emphasize that morphologically similar cells are wired together very differently within the local circuit. The classes of hippocampal interneurons we have tentatively defined may be used during distinct behavioral states to switch the local network from one oscillatory state to another.

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Physiology, Pharmacology, and Topography of Cholinergic Neocortical Oscillations In Vitro

Cited by 74 publications

References 96 publications

Spiral Waves in Disinhibited Mammalian Neocortex

Spiral Waves in Disinhibited Mammalian Neocortex

Conditional Bursting Enhances Resonant Firing in Neocortical Layer 2–3 Pyramidal Neurons

Functionally Distinct Groups of Interneurons Identified During Rhythmic Carbachol Oscillations in HippocampusIn Vitro

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