Physiology of the Airway

Wilson, William C.; Benumof, Jonathan L.

doi:10.1016/b978-1-4377-2764-7.00005-1

Cited by 6 publications

(3 citation statements)

References 188 publications

(238 reference statements)

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“…Derived variables, such as cardiac index, stroke volume index, systemic and pulmonary vascular resistance index, left ventricular stroke work index (LVSWI), oxygen delivery index (D o 2 I), and oxygen consumption index (V o 2 I) were calculated using standard formulas as in previous studies ( 18 ). Dynamic lung compliance was calculated as tidal volume/(peak inspiratory pressure – PEEP) ( 21 ). The cumulative fluid balance was estimated as the difference between cumulative infusion volume and cumulative urine output.…”

Section: Methodsmentioning

confidence: 99%

A Selective V1A Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock*

Taccone

et al. 2016

Critical Care Medicine

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Section: Methodsmentioning

confidence: 99%

A Selective V1A Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock*

Taccone

et al. 2016

Critical Care Medicine

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“…The main limitation of this study is the experimental model. The lungs were evaluated outside the thoracic cavity, a condition that prevents adequate lung distension and retraction during the respiratory cycle [37]. The results presented and the findings observed in each experimental group of this study refer to an ex vivo experimental condition, a situation that is different from the respiratory dynamics normally observed in live animals in which lungs are continuously expanded by air under the influence of different ventilatory pressures.…”

Section: Discussionmentioning

confidence: 98%

Comparison of Different Pneumorrhaphy Methods after Partial Pulmonary Lobectomy in Dogs

da Silva,

Lopes,

Stallmach

et al. 2023

Animals

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Pulmonary loborraphy can be performed using manual sutures and staples, although other methods, such as tissue adhesives, are also cited in the veterinary literature. Although the surgery is well tolerated in the canine species, failure in pulmonary aerostasis is still a reality since all the methods described so far eventually lead to air leakage after the use of the partial lobectomy technique in the lungs. Within this context, the aim of this research was to compare the effectiveness of different hermetic sealing methods after partial lobectomy of the right caudal lung lobe (RCLL) in dogs. 30 cadavers models were divided in 6 groups: G1—cobbler suture associated with simple continuous; G2—overlapping continuous suture associated with simple continuous suture; G3—Ford interlocking suture; G4—Stapling device; G5—Tissue glue (cyanoacrylate). After performing the sealing techniques, the lungs were submerged in water and inflated with oxygen at positive ventilatory pressures at physiological (up to 14.7 mmHg, which is equivalent to up to 20 cmH2O) and supraphysiological levels (above 14.7 mmHg) to evaluate the performance of the sealing methods. At physiological ventilatory pressure levels, there was no difference between groups. Sealing with surgical glue was superior to interlocking sutures and stapling devices at supraphysiological levels of ventilatory pressure.

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“…The main limitation of this study is the experimental model. The lungs were evaluated outside the thoracic cavity, a condition that prevents adequate lung distension and retraction during the respiratory cycle 37 . Under laboratory conditions accurate assessment of the sealing methods against physiological variations of ventilatory pressures is not completely possible.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Different Synthesis Methods After Partial Pulmonary Lobectomy in Dogs

Silva

Lopes

Stallmach

et al. 2022

Preprint

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Background: Pulmonary loborraphy can be performed using manual sutures and staples, although other methods such as tissue adhesives are also cited in the veterinary literature. However, despite the wide availability, no efficient suture material has yet been recognized that is completely safe in preventing any air leakage, a complication that is heavily investigated in medicine and not uncommon in veterinary medicine, despite the few studies and reports in dogs. Although the surgery is well tolerated in the canine species, failure in pulmonary aerostasis is still a reality, since all the methods described so far eventually lead to air leakage after the use of the partial lobectomy technique in the lungs. Within this context, the aim of this research was to compare the effectiveness of different hermetic sealing methods after partial lobectomy of the right caudal lung lobe (RCLL) in dogs. Using 30 cadaver models of canine lungs obtained immediately after death. The 30 cadavers models were divided in 6 groups: G1 - cobbler suture associated with simple continuous; G2 - overlapping continuous suture associated with simple continuous suture; G3 - Ford interlocking suture; G4 - Stapling device; G5 - Tissue glue (cyanoacrylate). After performing the sealing techniques, the lungs were submerged in water, inflated with oxygen at positive ventilatory pressures at physiological (20 cmH2O) and supraphysiological levels (above 20 cmH2O) to evaluate the performance of the sealing methods and to asses the level of ventilatory pressures at which air leakage occur. Results: At physiological ventilatory pressure levels there was no difference between groups. However, when evaluating such methods at ventilation pressure levels above 20 cmH2O, it was found a superiority of G5 over G3 and G4. Conclusion: Manual sutures, as well as staples and synthetic tissue glue were able to promote aerostasis after partial lobectomy of the RCLL at physiological ventilatory pressures. Sealing with surgical glue was superior to Ford interlocking suture and stapling device at supraphysiological levels of ventilatory pressure. This study supports the efficay of all manual, mechanical sutures and synthetic glue sealant when used after partial lobectomy in dogs.

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Physiology of the Airway

Cited by 6 publications

References 188 publications

A Selective V1A Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock*

A Selective V1A Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock*

Comparison of Different Pneumorrhaphy Methods after Partial Pulmonary Lobectomy in Dogs

Comparison of Different Synthesis Methods After Partial Pulmonary Lobectomy in Dogs

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