Physiology of prevertebral ganglia in mammals with special reference to inferior mesenteric ganglion

Szurszewski, Joseph H.; King, BF

doi:10.1002/cphy.cp060115

Cited by 23 publications

(25 citation statements)

References 496 publications

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“…Previous electrophysiological studies have found that the activity of fast cholinergic inputs to IMG neurons from the myenteric plexus are increased by intracolonic pressure (Crowcroft et al, 1971;Szurszewski and K ing, 1991;By water, 1993;Miller and Szurszewski, 1997). Noncholinergic slow excitatory potentials that have also been observed in these cells are thought to originate in part from transmitters released from primary afferent fibers (Peters and Kreulen, 1984Kreulen and Peters, 1986).…”

Section: Discussionmentioning

confidence: 98%

“…A small population of myenteric neurons in the colon have "intestinof ugal" projections directly to the prevertebral ganglia, where they may reflexly regulate sympathetic outflow to the gut (Crowcroft et al, 1971;Dalsgaard and Elf vin, 1982;Furness et al, 1990;Keef and Kreulen, 1990;Szurszewski and K ing, 1991;Bywater, 1993;Messenger and Furness, 1993;L uckensmeyer and Keast, 1995;Miller and Szurszewski, 1997;Sharkey et al, 1998).…”

Section: Abstract: Neuropeptide Y; Somatostatin; Prevertebral Ganglimentioning

confidence: 99%

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Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

1999

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Activation of neurons in the inferior mesenteric ganglion (IMG) was assessed using c-fos, JunB, and c-Jun expression in the guinea pig IMG and colonic myenteric plexus during mechanosensory stimulation and acute colitis in normal and capsaicin-treated animals. Intracolonic saline or 2% acetic acid was administered, and mechanosensory stimulation was performed by passage of a small (0.5 cm) balloon either 4 or 24 hr later. Lower doses of capsaicin or vehicle were used to activate primary afferent fibers during balloon passage. c-Jun did not respond to any of the stimuli in the study. c-fos and JunB were absent from the IMG and myenteric plexus of untreated and saline-treated animals. Acetic acid induced acute colitis by 4 hr, which persisted for 24 hr, but c-fos was found only in enteric glia in the myenteric plexus and was absent from the IMG.Balloon passage induced c-fos and JunB in only a small subset of IMG neurons and no myenteric neurons. However, balloon passage induced c-fos and JunB in IMG neurons (notably those containing somatostatin) and the myenteric plexus of acetic acid-treated animals. After capsaicin treatment, c-fos and JunB induction by balloon passage was inhibited in the IMG, but there was enhanced c-fos expression in the myenteric plexus. c-fos and JunB induction by balloon stimulation was also mimicked by acute activation of capsaicin-sensitive nerves. These data suggest that colitis enhances reflex activity of the IMG by a mechanism that involves activation of both primary afferent fibers and the myenteric plexus.

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Section: Discussionmentioning

confidence: 98%

Section: Abstract: Neuropeptide Y; Somatostatin; Prevertebral Ganglimentioning

confidence: 99%

Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

1999

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“…Szurszewski & King, 1989). In the experiments made on acutely dissociated neurons, we used the patch clamp technique in the whole-cell recording configuration (Hamill, Marty, Neher, Sakmann & Sigworth, 1981;Sakmann & Neher, 1983) on small cells with no apparent processes.…”

Section: Atp As a Neurotransmittermentioning

confidence: 99%

“…Sympathetic neurons, via nicotinic synapses in prevertebral ganglia such as the coeliac and interior mesenteric ganglia, are responsible for the main extrinsic inhibitory control of gastrointestinal motility (Kreulen & Szurszewski, 1979;Szurszewski & King, 1989;McLachlan & Meckler, 1989). If the complementary action of ACh and ATP is a general property of neurons controlling the gastrointestinal tract (e.g.…”

Section: Introductionmentioning

confidence: 99%

On the excitatory effects of ATP and its role as a neurotransmitter in coeliac neurons of the guinea‐pig.

Silinsky

Gerzanich

1993

The Journal of Physiology

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SUMMARY1. The effects of ATP on neurons from guinea-pig coeliac ganglia were studied to evaluate the possibility that this nucleotide acts as an excitatory neurotransmitter substance.2. In experiments with intracellular microelectrodes, ATP ( > 100 nM) depolarized coeliac neurons from the resting potential and produced an increase in the membrane conductance. These excitatory effects of ATP were observed in isolated coeliac ganglia, in acutely dissociated neurons or in cultured neurons. ATP also produced membrane conductance increases in neurons clamped at the resting potential using a single electrode voltage clamp.3. When studied in the whole-cell configuration of the patch clamp (intracellular Cs' to block K+ currents; -50 mV holding potential), ATP evoked inward currents in a manner more potent and efficacious than acetylcholine (ACh).4. Whole-cell currents induced by ATP were inwardly rectifying and reversed at -13 mV in normal Na+ solutions. Changes in extracellular Na+ concentration altered the reversal potential in a manner predicted by the Goldman-Hodgkin-Katz bi-ionic equation with a ratio of Na+ to Cs+ permeability (PNa/PCs) = 0-6. 5. Single channel currents were evoked by ATP in excised (outside-out) patches. Current-voltage relationships for single channel currents exhibited inward rectification. The mean single channel conductance was 22 pS at -50 mV.6. Antagonists of ATP-gated channels (suramin, Reactive Blue 2) reduced the effects of ATP but not ACh.7. Antagonists at nicotinic receptors/ion channels (hexamethonium or tubocurarine) reduced the effects of ACh but not ATP.8. Excitatory synaptic currents were observed in cultures of coeliac neurons. Synaptic currents possessed similar current-voltage relationships to currents produced by ATP, were increased in frequency by K+ depolarization in a Ca'+-dependent manner, and were selectively antagonized by ATP antagonists.

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“…The SCG is divided into distinct compartments by capsular septa of connective tissue as reported for mammalian sympathetic ganglia (Fioretto et al, 2007;Gabella et al, 1988;Miolan and Niel, 1996;Ribeiro et al, 2004;Schmidt, 1996;Szurszewski and King, 1989;Szurszewski and Miller, 1994). In addition, Gabella (1976) postulated that the capsule of connective tissue which surrounds the ganglia of the sympathetic trunk is continuous with the epineurium of the associated nerves.…”

Section: B978mentioning

confidence: 93%

Stereological and Allometric Studies on Neurons and Axo-Dendritic Synapses in Superior Cervical Ganglia

Ladd¹,

Ladd²,

Silva³

et al. 2014

International Review of Cell and Molecular Biology

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Physiology of prevertebral ganglia in mammals with special reference to inferior mesenteric ganglion

Cited by 23 publications

References 496 publications

Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

On the excitatory effects of ATP and its role as a neurotransmitter in coeliac neurons of the guinea‐pig.

Stereological and Allometric Studies on Neurons and Axo-Dendritic Synapses in Superior Cervical Ganglia

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