Physiology of Hemostasis

Bick, Rodger L.; Murano, Genesio

doi:10.1016/s0272-2712(18)30352-4

Cited by 34 publications

(17 citation statements)

References 76 publications

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“…43 The Ca 2+ ion is also central in several of the enzymatic steps leading to the production of fibrin. 44 It further has an important function in tissue repair and regulation by being an essential part of the intracellular signal transduction system that brings about cell growth and metabolism. 45 The availability of inorganic phosphate is also essential for the biochemical processes related to mucositis.…”

Section: Discussionmentioning

confidence: 99%

A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation

Papas

Clark

Martuscelli

et al. 2003

Bone Marrow Transplant

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Summary:Oral mucositis is a complication common to many cancer therapies and produces considerable pain and morbidity. The present study reports a double-blind, prospective, randomized clinical trial testing the efficacy of a calcium phosphate mouth rinse (Caphosol s ) with fluoride treatments vs a standard regimen of fluoride rinsing and placebo tray treatments in 95 patients undergoing hematopoietic stem cell transplantation (HSCT). The days and severity of mucositis were prospectively evaluated. There were statistically significant decreases in days of mucositis (3.72 vs 7.22 P ¼ 0.001), duration of pain (2.86 vs 7.67, P ¼ 0.0001), dose of morphine (34.54 mg vs 122.78 mg), days of morphine (1.26 vs 4.02, P ¼ 0.0001) and days to the onset of engraftment ANC (absolute neurotrophil count)4200 mm 3 (11.12 vs 12.56) in the Caphosol s and fluoride treatment group vs fluoriderinse group, respectively. Caphosol s , a neutral, supersaturated, Ca 2+ /PO 4 3À mouth rinse, used in combination with topical fluoride treatments, is superior to fluoride rinse alone in reducing the frequency, intensity and duration of oral mucositis in patients undergoing HSCT.

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Section: Discussionmentioning

confidence: 99%

A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation

Papas

Clark

Martuscelli

et al. 2003

Bone Marrow Transplant

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“…However, the researchers agree that the saliva saturated with calcium and phosphorus ions promotes remineralization of the tooth enamel [7]. Ca 2+ ions are involved in changes of cell membrane potential which affects the enzymatic pathways of many metabolic processes that lead to the production of fibrin [8,9]. Moreover, Ca 2+ ions play a very important role in tissue repair and regulation mechanisms by being an essential part of the intracellular signal transduction system that brings about cell growth and metabolism [10].…”

Section: Discussionmentioning

confidence: 99%

Oral Hygiene Status and Selected Saliva Biomarkers in Children with Acute Lymphoblastic Leukaemia During Anticancer Therapy

Pels¹

2013

J Leuk

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Altered secretion of saliva and its changed composition in patients undergoing chemotherapy often results in oral mucosa pathologies. The aim of this study was to assess the impact of oral hygiene and the concentration of calcium, phosphate and magnesium ions in the saliva on developing oral mucositis in children with acute lymphoblastic leukaemia (ALL) during anticancer therapy. The study included 78 children, aged from 2 to 18 yrs suffering from ALL on anticancer therapy. The results of biochemical scores found that the concentrations of calcium, phosphate and magnesium ions in the saliva of children with ALL were affected. Oral hygiene condition and lower concentrations of selected biomarkers in the saliva in children with ALL during chemotherapy may affect the intensity of the pathological changes in the oral mucosa.In the group of children examined unstimulated saliva was collected in the morning two hours after a meal to determine the concentration of calcium, phosphorus and magnesium ions. The samples of collected saliva were centrifuged for 15 min at 5,000 rot/min. The centrifuged saliva samples were frozen at -80°C, until the time of biochemical scores.The concentration of calcium ions was determined by the colorimetric method of Arsenazo III at neutral pH, the complex was read at 660nm wavelength with the use of reagent kit Konelab™ CALCIUM, Thermo Electron Corporation.The concentration of phosphorus ions was determined calorimetrically by the direct method without deproteinization by measuring UV absorption of the resulting phosphorus-molybdenum complex formed in the acidic environment/absorption at 340 nm wavelength is proportional to the concentration of phosphate ions in the material tested. The measurement was done using reagent kit Phosphorus UV BioMerieux.The concentrations of magnesium ions were determined by colorimetric method without deproteinization, using calmagite as chromogen and the reagent kit Mg-Kit, BioMérieux.Microelements were determined on a biochemical analyzer Konelab Kone Pro.The results were analyzed statistically. The measurable parameters were presented as mean, Median, minimum and maximum values and standard deviation. Mann-Whitney U test was used to compare 2 independent groups, Spearman's Rank Order Correlation test was used to analyze the relationship between two quantitative parameters;

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“…Vascular damage has been reported to occur with several acute toxicities after BMT, [40][41][42] yet the vasculature remains the most poorly understood with respect to disorders of hemostasis. 43 Identification of underlying mechanisms may greatly assist in predicting the risk of bleeding in thrombocytopenic patients.…”

Section: Tablementioning

confidence: 99%

Acute bleeding and thrombocytopenia after bone marrow transplantation

Nevo¹,

Enger²,

Hartley³

et al. 2001

Bone Marrow Transplant

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Summary:The relationship between hemorrhage and low platelet count was first established in patients with acute leukemia, and has been widely applied to thrombocytopenic patients, including BMT patients. Yet, the role of thrombocytopenia in bleeding post BMT has not been systematically studied. We evaluated the risk of bleeding and outcome associated with thrombocytopenia in BMT patients who had prophylactic platelet transfusions at a trigger of 20 × 10 9 /l. Thrombocytopenia was investigated in 321 patients with moderate or severe bleeding (BLD), and in a matched comparison group of 287 patients who did not bleed (NBLD). Profound thrombocytopenia (р10 × 10 9 /l) was found in 8.6% of the BLD patients during the week before the bleeding onset, significantly more frequent than in NBLD patients (2.1% to 4%, P Ͻ 0.02), during weeks 2 to 6 post BMT (the period when 75% of the bleeding initiated). On the first day of bleeding, platelet counts Յ10 × 10 9 /l were found in 13.5%, 11-20 × 10 9 /l in 20.4%, and Ͼ20 × 10 9 /l in 66.1% of all episodes. Overall survival in BLD patients was not associated with the severity of thrombocytopenia before bleeding onset. Severity of thrombocytopenia was significantly associated with reduced survival in NBLD patients. We concluded that bleeding post BMT was significantly associated with thrombocytopenia, but the attributable risk of bleeding from profound thrombocytopenia was not large. Thrombocytopenia may be an important clinical sign in NBLD patients, and should be further explored in relation to acute toxicities other than bleeding. Bone Marrow Transplantation (2001) 27, 65-72.

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Physiology of Hemostasis

Cited by 34 publications

References 76 publications

A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation

A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation

Oral Hygiene Status and Selected Saliva Biomarkers in Children with Acute Lymphoblastic Leukaemia During Anticancer Therapy

Acute bleeding and thrombocytopenia after bone marrow transplantation

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