Physiology of fever

Broom, M.

doi:10.7748/paed.19.6.40.s32

Cited by 24 publications

(18 citation statements)

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“…Variable selection for studying potential characteristics of revisits were based on previously published decision models or risk scores [ 2 , 3 , 8 ] and a recent systematic review on characteristics of pediatric health care revisits (Table 1 ) [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Characteristics of revisits of children at risk for serious infections in pediatric emergency care

et al. 2018

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In this study, we aimed to identify characteristics of (unscheduled) revisits and its optimal time frame after Emergency Department (ED) discharge. Children with fever, dyspnea, or vomiting/diarrhea (1 month–16 years) who attended the ED of Erasmus MC-Sophia, Rotterdam (2010–2013), the Netherlands, were prospectively included. Three days after ED discharge, we applied standardized telephonic questionnaires on disease course and revisits. Multivariable logistic regression analysis was used to identify independent characteristics of revisits. Young age, parental concern, and alarming signs and symptoms (chest wall retractions, ill appearance, clinical signs of dehydration, and tachypnea) were associated with revisits (n = 527) in children at risk for serious infections discharged from the ED (n = 1765). Children revisited the ED within a median of 2 days (IQR 1.0–3.0), but this was proven to be shorter in children with vomiting/diarrhea (1.0 day (IQR 1.0–2.0)) compared to children with fever or dyspnea (2.0 (IQR 1.0–3.0)).Conclusion: Young age, parental concern, and alarming signs and symptoms (chest wall retractions, ill appearance, clinical signs of dehydration, and tachypnea) were associated with emergency health care revisits in children with fever, dyspnea, and vomiting/diarrhea. These characteristics could help to define targeted review of children during post-discharge period. We observed a disease specific and differential timing of control revisits after ED discharge. What is Known • Fever, dyspnea, and vomiting/diarrhea are major causes of emergency care attendance in children.• As uncertainty remains on uneventful recovery, patients at risk need to be identified on order to improve safety netting after discharge from the ED. What is New • In children with fever, dyspnea, and vomiting/diarrhea, young age, parental concern and chest wall retractions, ill appearance, clinical signs of dehydration, and tachypnea help to define targeted review of children during the post-discharge period.• A revisit after ED discharge is disease-specific and seems to be shorter for children with vomiting/diarrhea than others.Electronic supplementary materialThe online version of this article (10.1007/s00431-018-3095-0) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Characteristics of revisits of children at risk for serious infections in pediatric emergency care

et al. 2018

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“…1 Increased temperature that cannot be tolerated by children or that more than 41°C and left untreated, can cause brain damage in the future (secondary brain damage) which can trigger febrile fever. 2,3 A child who shows the risk of secondary brain damage should be monitored and treated to prevent further complications.…”

Section: Introductionmentioning

confidence: 99%

“…This happens because of a lack of information about the fever and its benefits as well as the inconsistent handling of fever in many hospitals. 3 Health education interventions to improve the knowledge of both the parents and caregivers about the fever and its management are very. It was also very effective in reducing the fear of parents and nurses, as well as reducing the use of antipyretics that are not required on the fever.…”

Section: Introductionmentioning

confidence: 99%

The effect of health education to parent’s behaviours on managing fever in children

Herman¹,

Nurshal²

2017

Int J Res Med Sci

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Background: Fever is one of the common signs that indicate the changes in the body. Generally, parents will do some aggressive actions in dealing with febrile children at home, especially in the use of antipyretic drugs that are not required by the body. The aim of this study is to describe the effect of health education on knowledge, attitude, and action of parents in managing fever of children in Pariaman’s General Hospital. The results of this research can be considered as one of the interventions in the treatment of children in hospital.Methods: The study design is a quasi-experimental with nonequivalent control group approach. Samples are parents who have children with fever sign that were treated in Pariaman’s General Hospital, West Sumatera, Indonesia. Samples were taken by a purposive sampling technique that is in accordance with the criteria set by the researchers. The samples were divided into two groups: the intervention and control groups. Health education about fever was given into intervention groups. In the control groups they received standard care from hospital. The data was collected by questionnaire, that consist of questions about knowledge, attitude an action of parent toward fever in their children. The data statistical was analyzed with independent t test.Results: There are significant differences on knowledge score (p value: 0.009), attitude (p value: 0:03) and action (p value: 0002) of parents between the intervention group and the control group.Conclusions: Therefore, it is expected that health workers and nurses can provide education / health education to parents about fever management in children.

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“…monocytes and macrophages) to release pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, which are often termed endogenous pyrogens, and can transmit fever reactions through an organism to the thermoregulatory centres of the brain. 2,4,5…”

Section: Introductionmentioning

confidence: 99%

Analysis of IL-6 and IL-1β release in cryopreserved pooled human whole blood stimulated with endotoxin

Gao

et al. 2018

Innate Immun

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To overcome the lack of availability of fresh human whole blood for pyrogen detection, we explored the feasibility of utilizing cryopreserved pooled human blood to detect the responses of the pro-inflammatory cytokines IL-6 and IL-1β to LPS. Whole blood was obtained from five donors and incubated with LPS. The quantities of pro-inflammatory cytokines were measured using ELISA, and the results were compared among the samples. After the blood was cryopreserved with Dimethyl sulfoxide (DMSO) (10% v/v) and stored for 4 mo at -196℃, the detection limits of the IL-6/IL-1β responses to LPS were 0.2/0.4 endotoxin units (EU)/ml, respectively, and IL-6/IL-1β release increased in response to LPS in a dose-dependent manner. When these experiments were performed in three separate laboratories, the within-laboratory reproducibility of the IL-6/IL-1β responses was 100%/86.7%, 93.3%/100%, and 86.7%/80%, and the inter-laboratory reproducibility was 92.9%/85.7%, 64.3%/63.6%, and 57.1%/66.7%, respectively. The sensitivity (the probability of correctly classifying positive samples) and specificity (the probability of correctly classifying negative samples) of the IL-6/IL-1β tests were 81.7%/82.5% and 100%/100%, respectively. The results of this study suggest that cryopreserved pooled blood is a convenient and viable alternative for evaluating in vitro pyrogenicity. Additionally, maintaining cryopreserved pooled blood promotes safety for the user because it is released only after pretesting for infection parameters and has lower variation than fresh donations from a variety of donors.

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Physiology of fever

Cited by 24 publications

References 0 publications

Characteristics of revisits of children at risk for serious infections in pediatric emergency care

Characteristics of revisits of children at risk for serious infections in pediatric emergency care

The effect of health education to parent’s behaviours on managing fever in children

Analysis of IL-6 and IL-1β release in cryopreserved pooled human whole blood stimulated with endotoxin

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