Physiology of cerebral venous blood flow: from experimental data in animals to normal function in humans

Schaller, Bernhard

doi:10.1016/j.brainresrev.2004.04.005

Cited by 229 publications

(271 citation statements)

References 71 publications

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“…The blood leaves the brain by using the back propulsion of the residual arterial pressure (vis a tergo), complemented by antegrade postural and respiratory mechanisms (vis a fronte) as shown in Figure 3 (Ursino and Lodi, 1997;Schaller, 2004;Menegatti and Zamboni, 2008).…”

Section: Physiology Of Cerebral Venous Return and Venous Blood Flow Amentioning

confidence: 99%

“…Additionally, the suboccipital cavernous sinus and the hemiazygous-lumbar venous anastomosis with the left renal vein may also become prominent substitute circles. Collateral circulation prevents brain edema and intracranial hypertension (Schaller, 2004;Zamboni et al, 2009a), and ensures a correct but slower, and thus insufficient, venous drainage.…”

Section: Figure 4 Extracranial Venous Stenosis Associated To Ms (Ccsvi)mentioning

confidence: 99%

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Anomalous Venous Blood Flow and Iron Deposition in Multiple Sclerosis

Singh

Zamboni

2009

J Cereb Blood Flow Metab

180

155

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Multiple sclerosis (MS) is primarily an autoimmune disorder of unknown origin. This review focuses iron overload and oxidative stress as surrounding cause that leads to immunomodulation in chronic MS. Iron overload has been demonstrated in MS lesions, as a feature common with other neurodegenerative disorders. However, the recent description of chronic cerebrospinal venous insufficiency (CCSVI) associated to MS, with significant anomalies in cerebral venous outflow hemodynamics, permit to propose a parallel with chronic venous disorders (CVDs) in the mechanism of iron deposition. Abnormal cerebral venous reflux is peculiar to MS, and was not found in a miscellaneous of patients affected by other neurodegenerative disorders characterized by iron stores, such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis. Several recently published studies support the hypothesis that MS progresses along the venous vasculature. The peculiarity of CCSVI-related cerebral venous blood flow disturbances, together with the histology of the perivenous spaces and recent findings from advanced magnetic resonance imaging techniques, support the hypothesis that iron deposits in MS are a consequence of altered cerebral venous return and chronic insufficient venous drainage.

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Section: Physiology Of Cerebral Venous Return and Venous Blood Flow Amentioning

confidence: 99%

Section: Figure 4 Extracranial Venous Stenosis Associated To Ms (Ccsvi)mentioning

confidence: 99%

Anomalous Venous Blood Flow and Iron Deposition in Multiple Sclerosis

Singh

Zamboni

2009

J Cereb Blood Flow Metab

180

155

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“…Labbé's vein (the inferior anastomotic vein) connects the superficial middle cerebral vein posteriorly over the lateral aspect of the temporal lobe to the transverse sinus. Its calibre shows an inverse relationship with that of Trolard's vein (the superior anastomotic vein connecting the superficial middle cerebral vein to the superior sagittal sinus) (3). We report a case of aseptic thrombosis of the left vein of Labbé associated with an ipsilateral dural sinus thrombosis, suspected on nonenhanced CT and confirmed on CT venography (CTV).…”

mentioning

confidence: 90%

Left vein of Labbé thrombosis associated with ipsilateral dural sinus thrombosis: non-enhanced CT and contrast-enhanced CT (CTV) findings

Stýblo-Sramek¹,

Temmerman

Verbist

2012

Journal of the Belgian Society of Radiology

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“…Recent models have even suggested that the blood flow that produces CSF affects not only the quantity and pulsatility of CSF, but also the pulsatility that is transmitted from the cerebral blood vessels to the CSF [10]. Various models have been postulated that describes the systemic arterial flow and whole cerebral blood flow, but as yet it is difficult to establish at the present time an accurate model that explains the relationship between cerebral blood flow and CSF pressure [9,11].…”

Section: Hemodynamics and Csf Dynamicsmentioning

confidence: 99%