New concept of cerebrospinal fluid dynamics in cerebral venous sinus thrombosis

Spontaneous intracranial hypotension and venous sinus thrombosis

“…32 In keeping with this, the area of the dural sinuses increases by ∼70% in SIH33 and reduced velocity of blood flow has been demonstrated in the straight sinus after lumbar puncture 36. However, increased blood viscosity due to reduced absorption of CSF into cerebral venous blood37 and distortion of venous structures due to the downward displacement of the brain32 may also contribute to the increased risk of thrombosis.…”

Hypothesis for lateral ventricular dilatation in communicating hydrocephalus: New understanding of the Monro-Kellie hypothesis in the aspect of cardiac energy transfer through arterial blood flow

“…The reduced venous drainage in venous sinus thrombosis usually decreases the CSF drainage and results in ventricular dilatation [25,26]. In some cases, the venous sinus thrombosis causes increased intracranial pressure without manifest ventricular enlargement, while in other cases of venous sinus thrombosis ventricular dilatation is observed in the initial stages but which gradually returns to normal dimensions as time passes [27]. This may be due to the degree of drainage from the obstructed venous sinus to the CSF and the extracellular fluid (ECF) of the brain parenchyme.…”

“…If there exists a venous sinus thrombosis that nonspecifically drains the ECF and CSF, a portion of the CSF would not be adequately drained, and the resulting disruption of the energy transfer and dissipation system would lead to mild lateral ventricular dilatation. However, compensatory collateral circulation formation via the capillaries would increase the CSF drainage to the brain parenchyme ECF as time passes [27]. Therefore, the disruption of the energy transfer and dissipation system that is caused by the decreased CSF drainage is compensated by the CSF drainage to the ECF.…”

Intracranial Hypotension Syndrome with Cortical Venous Thrombosis: A Rare Case

“…Secondly, SIH leads to caudal displacement of the brain due to decreased CSF buoyancy (10), which stretches the venous sinuses resulting in endothelial injury (6). Thirdly, CSF loss leads to its decreased absorption, which causes increased viscosity (11). However, the presence of SIH should not prevent the search for other thrombotic risk factors.…”