Physiology and anatomy of neurons in the medial superior olive of the mouse

Fischl, Matthew J.; Burger, R. Michael; Schmidt-Pauly, Myriam; Alexandrova, Olga; Sinclair, James L.; Grothe, Benedikt; Forsythe, Ian D.; Kopp‐Scheinpflug, Conny

doi:10.1152/jn.00523.2016

Cited by 30 publications

(35 citation statements)

References 89 publications

(160 reference statements)

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“…Koch et al (2004) show that these channels are expressed in the somatic and dendritic compartments of MSO neurons. Block of Kv3 channels broadens the large action potentials in mice (Fischl et al, 2016). As action potentials in adult gerbil MSO neurons are very small, the presence and function of high voltage-activated potassium channels is unclear.…”

Section: Introductionmentioning

confidence: 99%

Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive

Nabel

Callan

Gleiss

et al. 2019

Front. Cell. Neurosci.

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Coincidence detector neurons of the medial superior olive (MSO) are sensitive to interaural time differences in the range of a few tens of microseconds. The biophysical basis for this remarkable acuity is a short integration time constant of the membrane, which is achieved by large low voltage-activated potassium and hyperpolarization-activated inward cation conductances. Additional temporal precision is thought to be achieved through a sub-cellular distribution of low voltage-activated potassium channel expression biased to the soma. To evaluate the contribution of potassium channels, we investigated the presence and sub-cellular distribution profile of seven potassium channel sub-units in adult MSO neurons of gerbils. We find that low- and high voltage-activated potassium channels are present with distinct sub-cellular distributions. Overall, low voltage-activated potassium channels appear to be biased to the soma while high voltage-activated potassium channels are more evenly distributed and show a clear expression at distal dendrites. Additionally, low voltage-activated potassium channel sub-units co-localize with glycinergic inputs while HCN1 channels co-localize more with high voltage-activated potassium channels. Functionally, high voltage-activated potassium currents are already active at low voltages near the resting potential. We describe a possible role of high voltage-activated potassium channels in modulating EPSPs in a computational model and contributing to setting the integration time window of coincidental inputs. Our data shows that MSO neurons express a large set of different potassium channels with distinct functional relevance.

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Section: Introductionmentioning

confidence: 99%

Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive

Nabel

Callan

Gleiss

et al. 2019

Front. Cell. Neurosci.

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“…In common laboratory rodents, the three main SOC (LSO, MSO and MNTB) are known targets of the cochlear nuclei and it is likely that a similar connectivity exists in marsupials (Aitkin et al, 1986;Bazwinsky-Wutschke, Hartig, Kretzschmar, & Rubsamen, 2016). The presence of a MSO is not surprising as it is known to persist in almost all mammalian species analysed including the mouse (Fischl et al, 2016;Ollo & Schwartz, 1979). The MSO is involved in detecting interaural timing differences related to sound localization of lower frequencies (Grothe & Sanes, 1994).…”

Section: Discussionmentioning

confidence: 99%

Physiological and anatomical investigation of the auditory brainstem in the Fat-tailed Dunnart (Sminthopsis crassicaudata)

Garrett

Lannigan

Yates

et al. 2019

Preprint

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The fat-tailed Dunnart (Sminthopsis crassicaudata) is a small (10-20g) native marsupial endemic to the south west of Western Australia. Currently little is known about the auditory capabilities of the dunnart, and of marsupials in general. Consequently, this study sought to investigate several electrophysiological and anatomical properties of the dunnart auditory system. Auditory brainstem responses (ABR) were recorded to brief (5ms) tone pips at a range of frequencies (4-47.5 kHz) and intensities to determine auditory brainstem thresholds. The dunnart ABR displayed multiple distinct peaks at all test frequencies, similar to other mammalian species. ABR showed the dunnart is most sensitive to higher frequencies increasing up to 47.5 kHz. Morphological observations (Nissl stain) revealed that the auditory structures thought to contribute to the first peaks of the ABR were all distinguishable in the dunnart. Structures identified include the dorsal and ventral subdivisions of the cochlear nucleus, including a cochlear nerve root nucleus as well as several distinct nuclei in the superior olivary complex, such as the medial nucleus of the trapezoid body, lateral superior olive and medial superior olive. This study is the first to show functional and anatomical aspects of the lower part of the auditory system in the Fat-tailed Dunnart.

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“…Likewise, CB-IR neurons were observed in the medial superior olive (MSO) of the bat [Zettel et al, 1991], whereas CB-IR neurons were not detected in the adult rat [Friauf, 1994], guinea pig [Caicedo et al, 1996], and cat [Adams and Mugnaini, 1990;Matsubara, 1990]. The MSO, which also belongs to the SOC in mice, is smaller and less organized than in many other mammals and is more difficult to distinguish from other nuclei [Fischl et al, 2016]. In mice, the MSO is difficult to identify in anatomical structure and function [Grothe, 2000], even though CaBPs were used as markers.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of Calbindin D28k, Parvalbumin, and Calretinin in the Superior Olivary Complex of Circling Mice

Lee¹,

Maskey

Kim

2017

Cells Tissues Organs

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The circling mouse serves as a hearing loss model. It has spontaneous tmie gene mutations that cause hair cell and cochlear degeneration. However, little is known about the role of the tmie gene in superior olivary complex (SOC) regions, in which sound information from the two ears is integrated and primarily relayed to the nuclei of the lateral lemniscus and inferior colliculus. Several studies have reported that abnormal calcium (Ca²⁺) homeostasis is associated with the pathology of hearing loss. This study investigated the distribution of Ca²⁺-binding proteins (CaBPs), such as calbindin D28k, parvalbumin, and calretinin, in the SOC of the circling mouse on postnatal day 16. A comparison of wild-type (+/+), heterozygous (+/cir), and homozygous (cir/cir) mice showed that CaBP immunoreactivity was significantly decreased in the auditory nucleus of the SOC of homozygous (cir/cir) mice. A decline in the CaBPs level in the SOC may be the result of hearing loss through hair cell and cochlear degeneration following tmie gene mutation.

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Physiology and anatomy of neurons in the medial superior olive of the mouse

Cited by 30 publications

References 89 publications

Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive

Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive

Physiological and anatomical investigation of the auditory brainstem in the Fat-tailed Dunnart (Sminthopsis crassicaudata)

Immunohistochemical Localization of Calbindin D28k, Parvalbumin, and Calretinin in the Superior Olivary Complex of Circling Mice

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