Physiological neutrophilia of pregnancy is not associated with a rise in plasma granulocyte colony‐stimulating factor (G‐CSF)

Abstract

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Changes in blood parameters in New Zealand White rabbits during pregnancy

“…WBC parameters, except for neutrophils, showed significant decreases during the late stage of pregnancy in the present study, and this is thought to be brought about by haemodilution. 2 However, it was reported that WBC parameters increased during the whole period of gestation in pregnant women 19–21 and rats, 12 and the reason for such a discrepancy between species remains obscure.…”

Changes in Clinical Pathology Parameters During Gestation in the New Zealand White Rabbit

“…WBC have been reported to increase throughout gestation in women, despite the hemodilutional effect that occurs (10,40,46 (56) and another has reported no change (12), many others have reported decreases (38,43,49). Decreases in platelet numbers were attributed solely to hemodilution because no evidence of increased platelet turnover (e.g., increased mean platelet volume, reticulated platelets) was observed.…”

Biologic and molecular effects of granulocyte colony-stimulating factor in healthy individuals: recent findings and current challenges

“…Whether the physiologic neutrophilia of pregnancy is associated with a rise in plasma G-CSF levels remains controversial. 6 In one study, 7 the serum G-CSF level in healthy volunteers was found to be 25.3 (Ϯ 19.7) pg/mL, with no detectable difference due to age or sex. The normal range is considered to be less than 78 pg/mL.…”