Physiological Growth, Remodeling Potential, and Preserved Function of a Novel Bioprosthetic Tricuspid Valve

Zafar, Farhan; Hinton, Robert B.; Moore, Ryan; Baker, Richard S.; Bryant, Roosevelt; Narmoneva, Daria A.; Taylor, Michael D.; Morales, David L.S.

doi:10.1016/j.jacc.2015.06.1091

Cited by 58 publications

(31 citation statements)

References 37 publications

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“…The report of Zafar et al (8) represents an important step towards the Holy Grail of developing a tissueengineered living heart valve. It also highlights several issues that need to be addressed before this becomes a clinical reality.…”

Section: Discussionmentioning

confidence: 99%

“…It should also reproduce the mechanical properties of the native valve, both in the short and long term. Two major types of scaffolds are currently being considered, the first are natural bioscaffolds prepared from decellularized non-cross-linked ECM, such as the one used in the report by Zafar et al (8), and decellularized valves and whole organs (9).…”

Section: Choice Of a Smart Scaffold Materialsmentioning

confidence: 99%

See 1 more Smart Citation

In Search of Living Valve Substitutes

Yacoub

2015

Journal of the American College of Cardiology

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Section: Discussionmentioning

confidence: 99%

Section: Choice Of a Smart Scaffold Materialsmentioning

confidence: 99%

In Search of Living Valve Substitutes

Yacoub

2015

Journal of the American College of Cardiology

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“…In less than four months after being sutured into pericardium this patch has transformed into pericardium itself [ 16 ], and used as tubular form sutured into tricuspid valve has formed into the valve tissue [ 17 ]. Provided the shaved aortic valve leaflets were fibrous, ECM-SIS patch attached might possibly form into keloid.…”

Section: Discussionmentioning

confidence: 99%

Aortic cusp extension valvuloplasty: repair with an extracellular patch

Przybylski¹,

Pawlak²,

Śliwka³

et al. 2015

kitp

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IntroductionThe proportion of valve repair procedures is increasing in experienced centers. The aim of the study was to assess the clinical and echocardiographic outcomes after aortic valve reconstruction with a novel surgical technique.Material and methodsThe study group consisted of 30 patients (23 male and 7 female) at a mean age of 35 ± 14 years. In patients with aortic root aneurysm the reimplantation or Florida sleeve technique was used. A sub-commissural annuloplasty, plication of the free edge of the cusp, shaving, and commissurotomy were performed. At this stage of surgery aortic repair was then attempted by cusp extension. Since 2013 the strips have been tailored from extracellular matrix.ResultsThe mean aortic cross-clamp time was 90 ± 32 min. The mean cardiopulmonary bypass time was 126 ± 38 min. There was no in-hospital death. Re-exploration for bleeding was required in 1 patient. During follow-up, 1 patient needed reoperation at 1 year due to endocarditis. All patients remained alive in New York Heart Association (NYHA) functional class I. The echocardiographic findings remained unchanged in all cases during follow-up.ConclusionsOur modification of aortic valve repair results in a good outcome.

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“…Zafar et al assessed the remodeling potential of TV by evaluating its growth, structure, and function in a growing ovine model. 59 The tricuspid valves of young sheep were replaced with TVs. At the 3-month and 8-month follow-ups, an incremental increase in the annular diameter similar to that of native valve was found.…”

Section: Heart Valvesmentioning

confidence: 99%

Regenerative Therapy for Patients with Congenital Heart Disease

Kimura

2018

Keio J. Med.

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Congenital heart disease (CHD) is the most common birth defect, affecting 1 in 100 babies. Among CHDs, single ventricle (SV) physiologies, such as hypoplastic left heart syndrome and tricuspid atresia, are particularly severe conditions that require multiple palliative surgeries, including the Fontan procedure. Although the management strategies for SV patients have markedly improved, the prevalence of ventricular dysfunction continues to increase over time, especially after the Fontan procedure. At present, the final treatment for SV patients who develop heart failure is heart transplantation; however, transplantation is difficult to achieve because of severe donor shortages. Recently, various regenerative therapies for heart failure have been developed that increase cardiomyocytes and restore cardiac function, with promising results in adults. The clinical application of various forms of regenerative medicine for CHD patients with heart failure is highly anticipated, and the latest research in this field is reviewed here. In addition, regenerative therapy is important for children with CHD because of their natural growth. The ideal pediatric cardiovascular device would have the potential to adapt to a child's growth. Therefore, if a device that increases in size in accordance with the patient's growth could be developed using regenerative medicine, it would be highly beneficial. This review provides an overview of the available regenerative technologies for CHD patients.

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Physiological Growth, Remodeling Potential, and Preserved Function of a Novel Bioprosthetic Tricuspid Valve

Abstract: In an ovine model, tubular SIS-ECM TV bioprostheses demonstrate "growth" and a cell-matrix structure similar to mature NVs while maintaining normal valve function. The SIS-ECM valve may provide a novel solution for TV replacement in children and adults.

Cited by 58 publications

References 37 publications

In Search of Living Valve Substitutes

In Search of Living Valve Substitutes

Aortic cusp extension valvuloplasty: repair with an extracellular patch

Regenerative Therapy for Patients with Congenital Heart Disease

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