Physiological effects of hyperthermia: response of capillary blood flow and structure to local tumor heating.

Emami, Bahman; Nussbaum, Gilbert H.; TenHaken, R.; Hughes, Walter L.

doi:10.1148/radiology.137.3.7444065

Cited by 66 publications

(15 citation statements)

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“…Progressive endothelial damage and capillary thrombosis was noted for approximately 30 minutes following the application of heat. Similar finding are confirmed in other tumor studies [19,36]. Some of the alterations in microvasculature may also be related to the local release of various cytokine.…”

Section: Discussionsupporting

confidence: 90%

“…It is also known that heat has a major impact on the blood flow dynamics in liver and tumors [19][20][21][22][23]. The knowledge concerning the mechanisms of tumor destruction and microcirculatory effects are however largely derived from whole-body hyperthermia, regional hyperthermia, and in vitro experiments.…”

Section: Discussionmentioning

confidence: 99%

“…Sublethal injury of the endothelium leading to alterations in blood flow and small vessel thrombosis may occur following the cessation of focal hyperthermia [19,20,30]. In a flank implantation tumor model, tumor ablation by radiofrequency resulted in delayed cell death with morphologic features suggestive of ischemia [20].…”

Section: Discussionmentioning

confidence: 99%

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Progressive microvascular injury in liver and colorectal liver metastases following laser induced focal hyperthermia therapy

et al. 2005

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Focal hyperthermia produces both progressive microvascular and tissue damage in liver and colorectal liver metastases. An increase in tissue injury following focal hyperthermia may be a direct result of progressive microvascular damage. Tumor vessels appear more susceptible to direct focal hyperthermia destruction than liver sinusoids. The liver sinusoids are however more susceptible to progressive damage or occlusion following the initial laser thermal stimulus.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Progressive microvascular injury in liver and colorectal liver metastases following laser induced focal hyperthermia therapy

et al. 2005

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“…It is largely determined by the efficiency of nutritive blood flow through tumors. Some recent experimental evidence suggests that hyperthermia has profound effects on tumor blood flow, including tumor microcirculation [3,5,7,9,18,30,34,39]. Histopathological studies of hyperthermic effects on the tumor microvasculature reveal patterns of gradual changes which likely cause these variations in tumor blood flow [6,8,40].…”

Section: Resultsmentioning

confidence: 99%

Oxygenation of malignant tumors after localized microwave hyperthermia

Vaupel

Otte

Manz

1982

Radiat Environ Biophys

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The oxyhemoglobin saturation (HbO2) of single red blood cells within tumor microvessels (diameter: 3-12 micrometers) of DS-Carcinosarcoma was studied using a cryophotometric micromethod. In untreated control tumors (mean tissue temperature approx. 35 degrees C) the measured values scattered over the whole saturation range from zero to 100 sat. %, the mean being 51 sat. %. Upon heating at 40 degrees C for 30 min, the oxygenation of the tumor tissue significantly improved as compared with control conditions. After 40 degrees C-hyperthermia a mean oxyhemoglobin saturation of 66 sat. % was obtained. In contradistinction to this, after 43 degrees C-hyperthermia the tumor oxygenation was significantly lower and reached a mean HbO2 saturation value of 47 sat. %. A further temperature rise to 45 degrees C caused the oxygenation to drop drastically (mean oxyhemoglobin saturation value: 24 sat. %). This is due to a severe restriction of nutritive blood flow. The changes in tumor oxygenation after hyperthermia seem to be predominantly mediated through changes in tumor blood flow, including tumor microcirculation, which showed a similar temperature dependence. Metabolic effects probably play a minor role in the oxyhemoglobin saturation distribution within tumor microvessels.

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“…It is caused by vasodilation in the context of an instant inflammatory response to thermal damage resulting in reactive hyperaemia [8,19]. This reaction can raise significant heat sink effects in the proximity of the ablation zone already during thermal ablation, although this hypothesis has never been proven and is certainly hard to verify.…”

Section: Discussionmentioning

confidence: 99%

Characterization of benign periablational enhancement following multipolar radiofrequency ablation using perfusion CT in an in-vivo porcine liver model

Vahldiek

Thieme

Gemeinhardt

et al. 2017

JCB

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Abstract. PURPOSE:Thermal ablation is an important interventional option in the management of liver tumors. Immediate postablational imaging regularly shows periablational enhancement. This peripheral hyperperfusion may induce heat-sink effects which could contribute to incomplete tumor ablation. To reduce the effect of hyperperfusion the feeding vessels source must be known. The aim of this study was to dynamically characterize the type of blood supply of the periablational enhancement zone immediately after hepatic radiofrequency ablation (RFA) using perfusion CT. METHODS:We used an in-vivo porcine liver model. Multipolar RFA was performed in healthy pig livers. Immediate postablational perfusion CT was acquired. The contrast enhancement over time of the peripheral ablation zone, the aorta and the portal vein were recorded. Time differences of the peak periablational enhancement to the peak arterial perfusion and to the peak portalvenous perfusion were calculated and analyzed. RESULTS: The perfusion peak of the periablational enhancement zone always occurred in mean 8.1 s after the arterial peak in the aorta and in mean 16.9 s before the peak in the portal vein. CONCLUSIONS: Benign periablational enhancement is a result of primary arterial and not portalvenous hyperperfusion. In order to reduce heat sink effects, peri-ablational arterial balloon occlusion or transarterial chemoembolization may be beneficial during RFA.

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Physiological effects of hyperthermia: response of capillary blood flow and structure to local tumor heating.

Cited by 66 publications

References 0 publications

Progressive microvascular injury in liver and colorectal liver metastases following laser induced focal hyperthermia therapy

Progressive microvascular injury in liver and colorectal liver metastases following laser induced focal hyperthermia therapy

Oxygenation of malignant tumors after localized microwave hyperthermia

Characterization of benign periablational enhancement following multipolar radiofrequency ablation using perfusion CT in an in-vivo porcine liver model

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