Physiological Daily Inhalation Rates for Free-Living Individuals Aged 1 Month to 96 Years, Using Data from Doubly Labeled Water Measurements: A Proposal for Air Quality Criteria, Standard Calculations and Health Risk Assessment

Brochu, Pierre; Ducré-Robitaille, Jean-François; Brodeur, Jean‐Paul

doi:10.1080/10807030600801550

Cited by 71 publications

(58 citation statements)

References 79 publications

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“…The adult human lungs inhale between 10,000 and 20,000 L of air daily, which interact with the vast 70 m 2 surface of the lungs (Brochu, Ducré-Robitaille, and Brodeur 2006;Frohlich et al 2016). While this makes lungs efficient for enabling gas exchange, it also makes pulmonary tissue highly vulnerable to airborne toxicants.…”

Section: Health Hazards Of Respiratory Exposuresmentioning

confidence: 99%

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

Benedikter

Wouters

Savelkoul

et al. 2018

Journal of Toxicology and Environmental Health, Part B

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Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses. Respiratory exposures such as cigarette smoke and air pollution exert cellular stresses and are associated with an increased risk of several chronic diseases. The aim of this review was to examine the evidence that modifications in EV contribute to respiratory exposure-associated diseases. Publications were searched using PubMed and Google Scholar with the search terms (cigarette smoke OR tobacco smoke OR air pollution OR particulate matter) AND (extracellular vesicles OR exosomes OR microvesicles OR microparticles OR ectosomes). All original research articles were included and reviewed. Fifty articles were identified, most of which investigated the effect of respiratory exposures on EV release in vitro (25) and/or on circulating EV in human plasma (24). The majority of studies based their main observations on the relatively insensitive scatter-based flow cytometry of EV (29). EV induced by respiratory exposures were found to modulate inflammation (19), thrombosis (13), endothelial dysfunction (11), tissue remodeling (6), and angiogenesis (3). By influencing these processes, EV may play a key role in the development of cardiovascular diseases and chronic obstructive pulmonary disease and possibly lung cancer and allergic asthma. The current findings warrant additional research with improved methodologies to evaluate the contribution of respiratory exposure-induced EV to disease etiology, as well as their potential as biomarkers of exposure or risk and as novel targets for preventive or therapeutic strategies.

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Section: Health Hazards Of Respiratory Exposuresmentioning

confidence: 99%

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

Benedikter

Wouters

Savelkoul

et al. 2018

Journal of Toxicology and Environmental Health, Part B

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“…Human being, on an average, inhales 14 m 3 air per day (Brochu et al, 2006). Presence of high concentration of microorganisms in the inhaled air thus can adversely affect health and activities of the people.…”

Section: Introductionmentioning

confidence: 99%

Microbiological pollutants in air and antibiotic resistance profile of some bacterial isolates

Kabir

Mridha

Islam

et al. 2016

Jahangirnagar Univ. J. Biol. Sci.

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Microbiological quality assessment is one of the most important investigations to determine the pollution of indoor and outdoor air. To evaluate the microbial load in air, samples were collected from 3 different outdoor and 3 different indoor sites within Jahangirnagar University campus. In outdoor air, bacterial and fungal counts varied from 117 -7284 CFU/m 3 and 88 -5287 CFU/m 3 , respectively. On the other hand, in indoor air bacterial and fungal counts varied from 440 -6226 CFU/m 3 and 88 -5874 CFU/m 3 , respectively. Furthermore, to reveal the antibiotic resistance profile, Staphylococcus aureus isolates were subjected to antibiogram study against 14 antibiotics. Among the isolates, 87.5% exhibited resistance to ceftazidime; 50% to penicillin G; 31.25 % to cefotaxime; 25 % to ceftriaxone, cefuroxime, cloxacillin; and 18.75% to amoxicillin. None of the isolates showed resistance to amikacin, ciprofloxacin, erythromycin, gentamicin, imipenem, nitrofurantoin and vancomycin. The presence of antibiotic-resistant bacteria in air may cause serious health hazard to the people living in this area.

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“…Daily average inhaled dose The daily average inhaled dose for each elder (E di ) was assessed by integrating the time spend in each micro-environment, the concentration of the pollutants for the period of interest, the inhalation rate (IR) and the body weight (BW) according Equation (3): The IR's associated with the three different micro-environments e bedroom, living-room and outdoor e were recommended by U.S. EPA (2011) for people with more than 61 years old in three distinct activities e sleep, sedentary and light intensity, respectively. These values were selected to be used as the recommended inhalation rates since they were based on three studies: U.S. EPA (2009), Stifelman (2007) and Brochu et al (2006). Table 6 presents the inhalation values used in this study.…”

Section: Daily Average Exposurementioning

confidence: 99%

Exposure and dose assessment to particle components among an elderly population

Almeida-Silva

Almeida

Pegas

et al. 2015

Atmospheric Environment

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h i g h l i g h t sElderly spend 95% of their time indoors. Indoor air quality was closely linked to personal exposure. The exposure and the inhaled dose of the studied elders differed significantly. The contribution of each indoor micro-environment depended on the particle constituents and respective sources. a r t i c l e i n f o b s t r a c tPeople spend the majority of their time indoors and the composition and toxicity of indoor particles is very complex and present significant differences comparing with outdoor aerosols. Consequently, ambient particles cannot represent a real exposure. The aim of this work was to determine the daily exposure and the daily inhaled dose to particle components of elders living in Elderly Care Centers. A questionnaire was applied to 193 institutionalized elders in order to achieve their daily time pattern and to define the micro-environments where PM 10 and its components (carbonaceous components and trace elements) were assessed. Daily exposure was calculated by integrating the elder's time spend in each micro-environment and the concentration of the pollutants for the period of interest. This parameter, together with the inhalation rate and the standard body weight, were used to calculate the daily inhaled dose. PM 10 daily exposure and daily inhaled dose ranged between 11 e 16 mg m À3 and 20 Â 10 À3 e 28 Â 10, respectively. This work not only allowed a fully quantification of the magnitude of the elders exposure, but also showed that the assessment of the integrated exposure to PM components is determinant to accomplish the dose inhaled by elders living in ECCs.

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Physiological Daily Inhalation Rates for Free-Living Individuals Aged 1 Month to 96 Years, Using Data from Doubly Labeled Water Measurements: A Proposal for Air Quality Criteria, Standard Calculations and Health Risk Assessment

Cited by 71 publications

References 79 publications

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

Microbiological pollutants in air and antibiotic resistance profile of some bacterial isolates

Exposure and dose assessment to particle components among an elderly population

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