Physiological Control of Growth Hormone in the Rabbit

McINTYRE, H.; Odell, William D.

doi:10.1159/000122548

Cited by 38 publications

(12 citation statements)

References 8 publications

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“…There were no significant differences in pituitary content of GH mRNA but pituitary content of GH was increased in rams fed lupin (P<0\m=.\05) and cowpea (P=0\m=.\07). In conclusion, a high-protein diet decreases plasma GH levels and increases IGF-I without changing plasma INTRODUCTION Numerous studies have shown that food restriction increases growth hormone (GH) levels in a wide range of species including man (Merimee & Fineberg, 1974;Ho et al 1988), sheep (Thomas et al 1990(Thomas et al , 1991Driver & Forbes, 1981;Foster et al 1989), pigs (Antinmo et al 1978), cattle (Blum et al 1985;Breier et al 1986) and rabbits (Mclntyre & Odell, 1974).…”

mentioning

confidence: 99%

Effect of high-protein feed supplements on concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in plasma and on the amounts of GH and messenger RNA for GH in the pituitary glands of adult rams

Clarke¹,

Fletcher

Pomares

et al. 1993

Journal of Endocrinology

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Three groups of mature rams were maintained on diets of hay, hay + 2% lupin or hay + 2% cowpea for 11 weeks. Serial blood samples were taken at 15-min intervals for 12 h for the determination of GH and IGF-I content by radioimmunoassay and for IGF-binding protein-3 (IGFBP-3) levels by Western blotting. The rams were killed after 77 days of supplementary feeding and their pituitary glands analysed for content of GH and GH mRNA. Mean plasma GH and baseline GH levels were significantly (P < 0.01) decreased in the rams fed lupin and cowpea compared with controls fed hay and GH pulse amplitude was significantly (P < 0.001) decreased in the group fed the cowpea diet. The frequency of GH pulses was not significantly altered by either treatment. Plasma concentrations of IGF-I were elevated in rams fed lupin (P < 0.001) or cowpea (P < 0.05). IGFBP-3 levels were not significantly (P > 0.05) altered by either treatment. There were no significant differences in pituitary content of GH mRNA but pituitary content of GH was increased in rams fed lupin (P < 0.05) and cowpea (P = 0.07). In conclusion, a high-protein diet decreases plasma GH levels and increases IGF-I without changing plasma IGFBP-3 levels in rams. Thus ongoing synthesis of GH, as indicated by the mRNA levels, may cause a build up of GH stores in the pituitary gland.

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mentioning

confidence: 99%

Effect of high-protein feed supplements on concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in plasma and on the amounts of GH and messenger RNA for GH in the pituitary glands of adult rams

Clarke¹,

Fletcher

Pomares

et al. 1993

Journal of Endocrinology

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“…In primates, insulin is a potent stimulus for GH release (1, lo), as it is in ruminants (2). It is less effective in pigs (2) and depresses circulating concentrations of GH in rats and rabbits (e.g., 3,6,11).…”

mentioning

confidence: 99%

Effects of Dietary Protein Restriction on Circulating Concentrations of Growth Hormone in Growing Domestic Fowl (Gallus domesticus)

Scanes¹,

Griminger²,

Buonomo³

1981

Experimental Biology and Medicine

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Two-to three-week-old broiler chicks were fed isocaloric purified diets with varying levels of protein (soy protein supplemented with glycine and methionine). The growth rates of the birds were monitored throughout the period of 14 days on the purified diets, while the circulating concentrations of growth hormone (GH) were determined at the end of this period. As expected, decreases in the dietary protein level were associated with concomitant reductions in growth rate. While this decrease in growth rate was observed with chicks fed 12 and 18% protein (compared with 24%), circulating concentrations of GH were observed to be only elevated with severe protein restriction ( 10% and lower). There was also evidence for some progressive increase in plasma concentrations of GH as dietary protein levels were decreased. 334

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“…Higher basal TSH levels in delayed sleep condition than in nocturnal sleep condition remain to be clarified. It has been recognized that the secretory pattern of plasma GH has an ultradian rhythm in rats (28), rabbits (29), sheep (30), baboons (3 1 ) and rhesus monkeys (32,33). From this point of view, the well documented GH-release following the sleep onset in humans is rather exceptional among mammals.…”

Section: Discussionmentioning

confidence: 99%

The 24‐hour Rhythms in Plasma Growth Hormone, Prolactin and Thyroid Stimulating Hormone: Effect of Sleep Deprivation

Sadamatsu

Kato

Iida

et al. 1995

J Neuroendocrinology

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Twenty-four hour secretory rhythms of growth hormone (GH), prolactin (PRL) and thyroid stimulating hormone (TSH) were investigated in 9 normal adult men by means of serial blood sampling at 30 min intervals. The profiles of pituitary hormones were compared in 6 subjects between in normal nocturnal sleep condition and in delayed sleep condition. Plasma GH was measured with use of highly sensitive enzyme immunoassay (EIA) recently developed. Plasma TSH was also evaluated by highly sensitive time-resolved fluorometric immunoassay (TR-FIA). Time series analysis of plasma GH and PRL was performed by auto- and cross- correlation and spectral analysis. The detection limit of EIA for GH was 0.3 pg/ml and all plasma GH levels were within the detectable range of this EIA. Cross-correlation and spectral analysis suggested the presence of approximately 2-3 h rhythmicity of plasma GH. Plasma PRL appeared to have some 24-hour rhythmicity besides its sleep-dependent component. Sleep deprivation caused marked elevation of plasma TSH during night time. It is suggested that there appears two mechanisms regulating GH secretion: one has a sleep-independent and ultradian rhythm and another has a sleep-dependent rhythm.

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Physiological Control of Growth Hormone in the Rabbit

Cited by 38 publications

References 8 publications

Effect of high-protein feed supplements on concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in plasma and on the amounts of GH and messenger RNA for GH in the pituitary glands of adult rams

Effect of high-protein feed supplements on concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in plasma and on the amounts of GH and messenger RNA for GH in the pituitary glands of adult rams

Effects of Dietary Protein Restriction on Circulating Concentrations of Growth Hormone in Growing Domestic Fowl (Gallus domesticus)

The 24‐hour Rhythms in Plasma Growth Hormone, Prolactin and Thyroid Stimulating Hormone: Effect of Sleep Deprivation

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