Effects of Dietary Protein Restriction on Circulating Concentrations of Growth Hormone in Growing Domestic Fowl (Gallus domesticus)

Scanes, Colin G.; Griminger, Paul; Buonomo, Frances C.

doi:10.3181/00379727-168-41282

Cited by 40 publications

(7 citation statements)

References 7 publications

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“…Growth rates, body weights, and feed consumption data of birds maintained on these purified diets has been reported previously (Scanes et al, 1981). Two weeks after birds began receiving experimental diets, MCR and SR were determined as described above except that the MCR, SR, and plasma concentrations of GH were measured in sodium pentobarbital-anesthetized chicks as well as in unanesthetized chicks.…”

Section: Methodsmentioning

confidence: 99%

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Effect of Age and Protein Restriction on the Clearance and Secretion of Growth Hormone in the Domestic Fowl

Lauterio

Scanes

1988

Poultry Science

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Metabolic clearance rates (MCR) and secretion rates for growth hormone (GH) were determined in young (6-wk-old) chicks and adults (1 yr old) as well as in chicks fed low protein diets for 2 wk. Birds were either conscious or anesthetized during these determinations in the latter study. Age-related differences in plasma concentrations of GH reflect greater secretion of GH in younger chicks (3.5-fold increase). The MCR was reduced by 35% in chicks compared with adults, but when expressed per unit metabolic body weight, was higher in the young chickens. The MCR in protein-restricted chicks was 28% lower than in that of controls. However, when the MCR was calculated on a metabolic body weight basis, protein-restricted and control chicks did not differ in MCR. Elevated plasma concentrations of GH in unanesthetized, protein-restricted chicks were due to greater GH secretion (2.4-fold) of these chicks compared with secretions of chicks fed control diets. Basal secretions of GH, determined in the anesthetized chicks, did not differ between dietary treatments. These results indicate that secretion of GH but not clearance was affected by protein restriction in conscious birds.

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Section: Methodsmentioning

confidence: 99%

“…Another example of plasma GH change is observed when chickens are fed a diet that is low in protein (Scanes et al, 1981). Birds so treated have plasma concentrations of GH that are three to four-fold greater than controls fed a diet adequate in protein content.…”

Section: Introductionmentioning

confidence: 96%

Effect of Age and Protein Restriction on the Clearance and Secretion of Growth Hormone in the Domestic Fowl

Lauterio

Scanes

1988

Poultry Science

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“…An increase in protein efficiency by dietary manipulation is also accom-628 F. R. LEENSTRASTAL. panied by an increase in GH concentrations in plasma (Scanes et al, 1981;Scanes, 1987, 1988;Nir et al, 1983;Harvey et al, 1978). In general, GH increases protein deposition and reduces lipogenesis (Scanes et al, 1984).…”

Section: Effects Of Age Selection Line and Sexmentioning

confidence: 97%

Concentrations of hormones, glucose, triglycerides and free fatty acids in the plasma of broiler chickens selected for weight gain or food conversion

Leenstra¹,

Decuypere

Beuving³

et al. 1991

British Poultry Science

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1. The concentrations of growth hormone (GH), insulin-like growth factor I (IGF-I), thyroxine (T4), triiodothyronine (T3), reverse-triiodothyronine (rT3), triglycerides (Tri), free fatty acids (FFA) and glucose (Glu) were determined at 2, 4 and 6 weeks of age in blood plasma of male and female chickens of broiler lines selected for body weight (GL) or food conversion (FC). 2. Plasma concentrations measured in the same animal over a 24 h or a 2 week interval were not significantly correlated with each other. For different traits measured in the same plasma sample only the correlation between T4 and rT3 differed significantly from zero. 3. All traits were dependent on age. Line and sex effects were significant (P less than 0.05) for GH, T4, Tri, FFA and Glu. Additionally, line significantly influenced the plasma T3/T4 ratio and sex influenced plasma rT3. Interactions between line, sex and/or age were seldom significant. 4. Within line and sex, GH (at 6 weeks of age) and T3 (at 4 weeks of age) were negatively, and IGF-I and Tri (both at 6 weeks of age) positively correlated with the amount of abdominal fat at 6 weeks of age. No significant correlation between body weight at 2, 4 or 6 weeks of age and any of the plasma traits was found.

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“…Protein-restricted chickens have raised plasma con¬ centrations of growth hormone (GH) compared with control birds fed adequate levels of protein (Scanes, Griminger & Buonomo, 1981;Lauterio & Scanes, 1987a). The metabolic factors involved in this response are unknown, although certain endocrine changes are consistent with the increase in plasma GH.…”

Section: Introductionmentioning

confidence: 97%

The role of thyroid hormones in the growth hormone response to protein restriction in the domestic fowl (Gallus domesticus)

Lauterio

Scanes²

1988

Journal of Endocrinology

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The possible role of thyroid hormones in the rise in plasma GH observed in protein-restricted chicks was examined. Increased sensitivity of protein-restricted chicks to secretagogue challenge (TRH or GH-releasing factor) appears to account, at least in part, for increased GH concentrations in protein-restricted chicks. Thyroid hormones administered acutely were able to suppress plasma GH concentrations in protein-restricted chicks. Further, chronic thyroid hormone supplementation to low protein diets normalized circulating thyroid hormone concentrations and also normalized the response to GH secretagogue challenge. This decreased sensitivity to TRH provocation occurred without an accompanying change in plasma concentrations of insulin-like growth factor-I, a reputed inhibitor of GH secretion in the chicken.

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Effects of Dietary Protein Restriction on Circulating Concentrations of Growth Hormone in Growing Domestic Fowl (Gallus domesticus)

Cited by 40 publications

References 7 publications

Effect of Age and Protein Restriction on the Clearance and Secretion of Growth Hormone in the Domestic Fowl

Effect of Age and Protein Restriction on the Clearance and Secretion of Growth Hormone in the Domestic Fowl

Concentrations of hormones, glucose, triglycerides and free fatty acids in the plasma of broiler chickens selected for weight gain or food conversion

The role of thyroid hormones in the growth hormone response to protein restriction in the domestic fowl (Gallus domesticus)

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