Physiological Changes at Parturition and Their Relationship to Metabolic Disorders

Goff, Jesse P.; Horst, Ronald L.

doi:10.3168/jds.s0022-0302(97)76055-7

Cited by 866 publications

(772 citation statements)

References 50 publications

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“…As a general practice, dairy cows receive two diets including far-off and close-up diets during a traditional dry period (,60 days) . The far-off diet is delivered during the first 5 weeks of the dry period and is designed to preserve body condition of the cow (Goff and Horst, 1997), whereas the close-up diet is delivered during the final 3 weeks of the dry period and is designed for adaptation of rumen microorganisms to the high-energy diet during early lactation . Nutritional stress may have negative physiological consequences during the dry period and in the subsequent lactation.…”

Section: Altered Dry Periodsmentioning

confidence: 99%

Effects of continuous lactation and short dry periods on mammary function and animal health

Collier

Annen-Dawson

Pezeshki

2012

Animal

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The dry period is required to facilitate cell turnover in the bovine mammary gland in order to optimize milk yield in the next lactation. Traditionally, an 8-week dry period has been a standard management practice for dairy cows based on retrospective analyses of milk yields following various dry period lengths. However, as milk production per cow has increased, transitioning cows from the nonlactating state to peak milk yield has grown more problematic. This has prompted new studies on dry period requirements for dairy cows. These studies indicate a clear parity effect on dry period requirement. First parity animals require a 60-day dry period, whereas lactations following later parities demonstrate no negative impact with 30-day dry period or even eliminating the dry period when somatotropin (ST) is also used to maintain milk yields. Shortened dry periods in first parity animals were associated with reduced mammary cell turnover during the dry period and early lactation and increased numbers of senescent cells and reduced functionality of lactating alveolar mammary cells postpartum. Use of ST and increased milking frequency postpartum reduced the impact of shortened dry periods. The majority of new intramammary infections occur during the dry period and persist into the following lactation. There is therefore the possibility of altering mastitis incidence by modifying or eliminating the dry period in older parity animals. As the composition of mammary secretions including immunoglobulins may be reduced when the dry period is reduced or eliminated, there is the possibility that the immune status of cows during the peripartum period is influenced by the length of the dry period.

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Section: Altered Dry Periodsmentioning

confidence: 99%

Effects of continuous lactation and short dry periods on mammary function and animal health

Collier

Annen-Dawson

Pezeshki

2012

Animal

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“…An excess of rumen degradable protein in the ration requires extra energy for the removal of surplus ammonia from the rumen [1], and this can lead to a higher incidence of clinical ketosis [45]. The most frequent reason for decompensated NEB, however, is probably the insufficient preparation of ruminal microorganisms for the digestion of large amounts of starch after calving when the roughage based ration of the dry period is replaced by substantial amounts of concentrate [32].…”

Section: Ketogenesis In Negative Energy Balance Cows During the Postpmentioning

confidence: 99%

Hyperketonemia and the impairment of udder defense: a review

et al. 2000

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-The objective of this study was to review the possible relationships between hyperketonemia and the function of phagocytes with respect to the bovine udder defense mechanism. We hypothesize that an increased incidence of clinical mastitis in high-producing cows is caused by the impairment of the udder defense mechanism during hyperketonemia. First, we review the acute phase of udder defense mechanisms after intramammary infection. The physiological changes of cows in negative energy balance are subsequently discussed. Finally, possible relationships between udder defense and physiological changes during negative energy balance, especially hyperketonemia, are reviewed. The three stages of an acute phase of udder defense are: (1) immediately eliminating invading pathogens by phagocytes, (2) releasing inflammatory substances, especially chemoattractants, and (3) migration of polymorphonuclear leukocytes into the infected udder. Leukocytes from hyperketonemia subjects show a lower capacity of the phagocytic defense mechanism. In addition, the phagocytic and bactericidal capacities of neutrophils are reduced when these cells are acting in the presence of high concentrations of ketone bodies. Lower amounts of cytokine production after bacterial infection are observed in ketotic subjects. The chemotactic capacity of blood leukocytes is impaired in leukocytes obtained from ketotic cows. Lower numbers of blood leukocytes are observed in ketotic cows. In conclusion, the impairment of the udder defense mechanism in negative energy balance cows seems related to hyperketonemia. ketosis / negative energy balance / mastitis / udder defense mechanism / cow Résumé -Hypercétonémie et diminution des défenses mammaires : une synthèse. L'objectif de cette étude est de présenter des relations possibles entre l'hypercétonémie et la fonction des phagocytes pour ce qui est des mécanismes de défense de la mamelle. Notre hypothèse est qu'une Vet. Res. 31 (2000) 397-412 397

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“…The transition from gestation to lactation is considered a critical period for high-producing dairy cows (Goff and Horst, 1997). The transition period is an important homeoretic event, in which several physiological modifications occur in a coordinated manner to support postpartum milk production (Drackley, 1999).…”

Section: Introductionmentioning

confidence: 99%

Effect of butaphosphan and cyanocobalamin on postpartum metabolism and milk production in dairy cows

Pereira

Silveira

Montagner

et al. 2013

Animal

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The aim of this study was to determine the effect of butaphosphan and cyanocobalamin (BTPC) supplementation on plasma metabolites and milk production in postpartum dairy cows. A total of fifty-two Holstein cows were randomly assigned to receive either: (1) 10 ml of saline (NaCl 0.9%, control group); (2) 1000 mg of butaphosphan and 0.5 mg of cyanocobalamin (BTPC1 group); and (3) 2000 mg of butaphosphan and 1.0 mg of cyanocobalamin (BTPC2 group). All cows received injections every 5 days from calving to 20 days in milk (DIM). Blood samples were collected every 15 days from calving until 75 DIM to determine serum concentration of glucose, non-esterified fatty acids (NEFA), b-hydroxybutyrate (BHB), cholesterol, urea, calcium (Ca), phosphorus (P), magnesium (Mg), aminotransferase aspartate (AST) and g-glutamyltransferase (GGT). The body condition score (BCS) and milk production were evaluated from calving until 90 DIM. Increasing doses of BTPC caused a linear reduction in plasma concentrations of NEFA and cholesterol. Supplementation of BTPC also reduced concentrations of BHB but it did not differ between the two treatment doses. Milk yield and milk protein had a linear increase with increasing doses of BTPC. A quadratic effect was detected for milk fat and total milk solids according to treatment dose, and BTPC1 had the lowest mean values. Concentrations of glucose, urea, P, Mg, AST, GGT, milk lactose and BCS were not affected by treatment. These results indicate that injections of BTPC during the early postpartum period can reduce NEFA and BHB concentrations and increase milk production in Holstein cows.Keywords: butaphosphan, cyanocobalamin, postpartum dairy cows, non-esterified fatty acid ImplicationsThis study presents a new metaphylactic strategy aimed to reduce the intensity of negative energy balance (NEB) in postpartum dairy cows. Unlike previous studies, the current protocol consists of five injections of cyanocobalamin and butaphosphan at 5 days interval during the first 20 days in milk (DIM), the period of greatest metabolic challenge for dairy cows. The results of this experiment indicate that this protocol can improve metabolic adaptation in the early postpartum period, by reducing adipose tissue mobilization and increasing milk production.

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Physiological Changes at Parturition and Their Relationship to Metabolic Disorders

Cited by 866 publications

References 50 publications

Effects of continuous lactation and short dry periods on mammary function and animal health

Effects of continuous lactation and short dry periods on mammary function and animal health

Hyperketonemia and the impairment of udder defense: a review

Effect of butaphosphan and cyanocobalamin on postpartum metabolism and milk production in dairy cows

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