Physiological and Psychological Illness Symptoms at High Altitude and Their Relationship With Acute Mountain Sickness: A Prospective Cohort Study

Oliver, Samuel J.; Sanders, Stephan; Williams, Catherine J.; Smith, Zoë; Lloyd-Davies, Emma; Roberts, Ross; Arthur, Calum A.; Hardy, Lew; Macdonald, Jamie

doi:10.1111/j.1708-8305.2012.00609.x

Cited by 34 publications

(35 citation statements)

References 35 publications

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“…Thus, future studies should implement a more robust sleep questionnaire, for example, the Groningen Sleep Questionnaire and/or direct polysomnography assessments. Third, due to the relatively small numbers of questionnaire items, the effect of other potential candidate factors, such as a history of previous AMS, migraine (Richalet et al, 2012;Canouï-Poitrine et al, 2014;Vinnikov et al, 2014), body mass index (obesity) (Beidleman et al, 2013), physical activity level (Beidleman et al, 2013), physical exertion (Roach et al, 2000), current smoking status (Beidleman et al, 2013;Vinnikov et al, 2014), cardiorespiratory responses to hypoxia (Oliver et al, 2012;Richalet et al, 2012;Canouï-Poitrine et al, 2014), and hydration status, including drinking habits (Mairer et al, 2009;Oliver et al, 2012), which have been investigated previously, on AMS in this population remains uncertain. Although future studies that include these items are warranted, our results clearly demonstrated that sleeping altitude may play an important role in increasing the prevalence and severity of AMS.…”

Section: Limitationsmentioning

confidence: 99%

Impact of Sleeping Altitude on Symptoms of Acute Mountain Sickness on Mt. Fuji

Horiuchi

Uno

Endo

et al. 2018

High Altitude Medicine & Biology

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Horiuchi, Masahiro, Tadashi Uno, Junko Endo, Yoko Handa, and Tatsuya Hasegawa. Impact of sleeping altitude on symptoms of acute mountain sickness on Mt. Fuji. High Alt Med Biol. 19:193-200, 2018. Aims: We sought to investigate the factors influencing acute mountain sickness (AMS) on Mt. Fuji in Japan, in particular, to assess the effects of sleeping altitude, by means of a questionnaire survey. This study involved 1932 participants who climbed Mt. Fuji, and obtained information regarding sex, age, and whether participants stayed at the mountain lodges. The AMS survey excluded the perceived sleep difficulties assessed with the Lake Louise Scoring (LLS) system for all climbers. Results: The overall prevalence of AMS was 31.6% for all participants (LLS score ‡3 with headache, excluding sleep difficulties). A univariate analysis revealed that overnight stay at Mt. Fuji was associated with an increased prevalence of AMS, but that sex and age were not. For overnight lodgers, the mean sleeping altitude in participants with AMS was slightly higher than that in participants without AMS ( p < 0.05). Moreover, participants who stayed above 2870 m were more likely to experience AMS than those who stayed below 2815 m ( p < 0.001), but sex and age were not significantly associated with the probability of experiencing AMS. Conclusions: Staying overnight at a mountain lodge, especially one above 2870 m, may be associated with an increased prevalence of AMS on Mt. Fuji.

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Section: Limitationsmentioning

confidence: 99%

Impact of Sleeping Altitude on Symptoms of Acute Mountain Sickness on Mt. Fuji

Horiuchi

Uno

Endo

et al. 2018

High Altitude Medicine & Biology

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“…Studies have shown that maladjustment of multiple factors, including respiration, gas exchange, and fluid balance, can lead to AMS [5]. However, the exact etiology and pathogenesis of AMS are not yet entirely clear, and susceptibility to AMS is markedly variable among individuals [6,7]. As a result, clinicians still cannot effectively predict susceptibility to AMS.…”

Section: Introductionmentioning

confidence: 99%

Association of Arterial Oxygen Saturation and Acute Mountain Sickness Susceptibility: A Meta-analysis

Guo

Zhu

Sun

et al. 2014

Cell Biochem Biophys

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Acute mountain sickness (AMS) is the most common high altitude illnesses experienced during rapid ascent to a higher altitude without prior acclimation. It is mainly characterized by a headache which may be accompanied with nausea, vomiting, anorexia, dizziness, lethargy, fatigue, and sleep disturbance. If not diagnosed and treated in a timely manner, AMS can develop into deadly high altitude pulmonary edema or high altitude cerebral edema. In the previous studies of individual variation in susceptibility to AMS, arterial oxygen saturation (SO2) was identified as being associated with AMS. However, other studies have reported no association between AMS and arterial oxygen saturation. In this study, the association between SO2 and AMS was assessed through a meta-analysis of published data. The literature databases PubMed, Web of Science, LWW, Science Direct, and Embase were queried for papers published before 15 April 2014. A fixed-effects model and a random-effects model were applied (Revman 5.0) on the basis of heterogeneity, and the study quality was assessed in duplicate. Twelve studies with 614 AMS patients and 1,025 control subjects were analyzed. There was a significant association with differences in SO2 and the risk of developing AMS. SO2 values are associated with AMS incidence.

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“…19 Therefore, the recommendation to increase fluid intake could possibly be one of the simplest interventions to reduce symptoms of altitude illness, as was recently concluded by Gatterer and colleagues and others. [20][21][22] On the other hand, it might be that dark urine merely is a consequence and not a risk factor of altitude illness.…”

Section: Predictorsmentioning

confidence: 95%