2009
DOI: 10.2174/1389557510909030386
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Physiological and Pathophysiological Functions of SIRT1

Abstract: The human SIRT1 is a nuclear enzyme from the class III histone deacetylases (HDACs) which is widely distributed in mammalian tissues. A variety of SIRT1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. This review emphasizes catalytic properties of SIRT1 and its role in apoptosis, insulin pathway, and neuron survival.

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Cited by 38 publications
(26 citation statements)
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“…The SIRT1 gene plays an important role in glucose and lipid metabolism [32]. One potential explanation for the significant association observed between rs3758391 and T2D, but not MS, is that this polymorphism, which is located in the promoter region of the SIRT1 gene, could alter the function of SIRT1 as a regulator of gluconeogenesis and insulin secretion [32,[60][61][62][63].…”
Section: Discussionmentioning
confidence: 99%
“…The SIRT1 gene plays an important role in glucose and lipid metabolism [32]. One potential explanation for the significant association observed between rs3758391 and T2D, but not MS, is that this polymorphism, which is located in the promoter region of the SIRT1 gene, could alter the function of SIRT1 as a regulator of gluconeogenesis and insulin secretion [32,[60][61][62][63].…”
Section: Discussionmentioning
confidence: 99%
“…3 Sirtuin activities are thought to mediate the beneficial effects of calorie restriction (CR), 4 which increases lifespan in a variety of organisms from yeast to mammals. 57 This compelling idea has been reinforced by a growing body of evidence that sirtuins are involved in regulating numerous physiologic processes such as adipogenesis, 8 fatty acid catabolism, 9 mitochondrial biogenesis, 10 and insulin secretion. 11,12 In addition to being the “master regulator” of metabolic programming, sirtuins have also been implicated in various pathological conditions and have been shown to be forceful potentiators and sustainers of diseases such as cancer.…”
mentioning
confidence: 99%
“…Over the past years, SIRT1 has been considered as an essential modulator of glucose and lipid homeostasis in different metabolic tissues, including liver, skeletal muscle, and white adipose tissue, as well as insulin secretion by pancreatic b cells and inflammation [9,10]. Therefore, establishing whether SIRT1 is related to PI3-K delta in GDM was of great interest to us.…”
Section: Prace Oryginalnementioning
confidence: 99%
“…Moreover, we sought to determine the relationship between the expression of PI3KCD and Sirtuin 1 (SIRT1) in leukocytes of the GDM patients since SIRT1 has received significant attention as a key NAD+-dependent deacetylase linking caloric restriction to mammalian cell life span, insulin secretion, and glucose/lipid metabolism [9,10].…”
Section: Introductionmentioning
confidence: 99%