Physiological and Pathological Remodeling of Cerebral Microvessels

Tregub, Pavel; Averchuk, Anton S.; Baranich, Tatyana I.; Ryazanova, Maria V.; Салмина, А. Б.

doi:10.3390/ijms232012683

Cited by 9 publications

(3 citation statements)

References 179 publications

(194 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The assessment of neurovascular dysfunction is of particular interest as it plays a crucial role in the onset and progression of the neurodegenerative process associated with the accumulation of β-amyloid peptide in brain neurons and cerebral vessel walls [ 85 , 86 ]. Special attention is given to the dysfunction of the blood–brain barrier, reduced cerebral blood flow, and impaired vascular clearance of beta-amyloid from the brain into the glymphatic system and meningeal lymphatic vessels [ 87 ].…”

Section: The Role Of Micrornas In Signaling Pathways Of Alzheimer’s-t...mentioning

confidence: 99%

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Tregub,

Ibrahimli,

Averchuk

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier.

show abstract

Section: The Role Of Micrornas In Signaling Pathways Of Alzheimer’s-t...mentioning

confidence: 99%

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Tregub,

Ibrahimli,

Averchuk

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Endothelial cells take part in the establishment of a new microvascular network either in embryogenesis (developmental vasculogenesis and angiogenesis) or in the adult brain (experience-and damage-driven angiogenesis). These mechanisms are based on the activity of endothelial progenitor cells, migrating non-proliferating tip-type endothelial cells, and proliferating stalk-type endothelial cells in the tissue [153]. Uptake of extracellular glucose for energy production is indispensable for angiogenesis and barriergenesis; thereby, blocking glucose transport in brain endothelial cells disrupts postnatal angiogenesis and the establishment of the barrier [154].…”

Section: Features Of Neurovascular Unit Cell Metabolism and Local Mic...mentioning

confidence: 99%

Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models

Kolotyeva,

Gilmiyarova,

Averchuk

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic transmission and remodeling, neurogenesis and angiogenesis, and changes in the metabolism associated with the establishment of new intercellular connections. Therefore, the extracellular scaffolds that are helpful in the establishment and maintenance of local microenvironments supporting brain plasticity mechanisms are of critical importance. In this review, we will focus on some carbohydrate metabolites—lactate, pyruvate, oxaloacetate, malate—that greatly contribute to the regulation of cell-to-cell communications and metabolic plasticity of brain cells and on some resorbable biopolymers that may reproduce the local microenvironment enriched in particular cell metabolites.

show abstract

“…Abnormal angiogenesis is involved in the pathogenesis of Moyamoya disease, which is often accompanied by cognitive and developmental delays or disability [127]. Aberrant angiogenesis and remodeling of brain microvessels is associated with disorganization of the BBB, neuroinflammation, and dysfunction of the neurovascular unit, resulting in neurological deficits [128,129]. In contrast, angiogenesis has curative roles in the recovery from ischemic stroke and depression [130,131].…”

Section: The Effects Of Ethanol On Angiogenesis/blood Vessel Remodelingmentioning

confidence: 99%

Blood Vessels as a Key Mediator for Ethanol Toxicity: Implication for Neuronal Damage

Nakayama

Hasegawa

2022

Life

View full text Add to dashboard Cite

Excessive intake of ethanol is associated with severe brain dysfunction, and the subsequent neurological and behavioral abnormalities are well-established social risks. Many research studies have addressed how ethanol induces neurological toxicity. However, the underlying mechanisms with which ethanol induces neurological toxicity are still obscure, perhaps due to the variety and complexity of these mechanisms. Epithelial cells are in direct contact with blood and can thus mediate ethanol neurotoxicity. Ethanol activates the endothelial cells of blood vessels, as well as lymphatic vessels, in a concentration-dependent manner. Among various signaling mediators, nitric oxide plays important roles in response to ethanol. Endothelial and inducible nitric oxide synthases (eNOS and iNOS) are upregulated and activated by ethanol and enhance neuroinflammation. On the other hand, angiogenesis and blood vessel remodeling are both affected by ethanol intake, altering blood supply and releasing angiocrine factors to regulate neuronal functions. Thus, ethanol directly acts on endothelial cells, yet the molecular target(s) on endothelial cells remain unknown. Previous studies on neurons and glial cells have validated the potential contribution of membrane lipids and some specific proteins as ethanol targets, which may also be the case in endothelial cells. Future studies, based on current knowledge, will allow for a greater understanding of the contribution and underlying mechanisms of endothelial cells in ethanol-induced neurological toxicity, protecting neurological health against ethanol toxicity.

show abstract

Physiological and Pathological Remodeling of Cerebral Microvessels

Cited by 9 publications

References 179 publications

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models

Blood Vessels as a Key Mediator for Ethanol Toxicity: Implication for Neuronal Damage

Contact Info

Product

Resources

About