Physiological and histopathological changes in the liver of male rats exposed to paracetamol and diazinon

Mossa, Abdel‐Tawab H.; Heikal, Tarek M.; Omara, Enayat A.

doi:10.1016/s2221-1691(12)60478-x

Cited by 29 publications

(23 citation statements)

References 33 publications

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“…No necrotic changes could be seen. Similar damage for liver tissues by APAP has been recorded [25][26][27][28]. SeNPs showed also ameliorative effect, histologically, on hepatotoxicity induced by drugs or parasites in several investigations [14,29].…”

Section: Resultssupporting

confidence: 56%

Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

AL-Harbi¹,

Amer²

2017

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Selenium nanoparticles (SeNPs) have been widely used as anti-inflammatory and anti-toxic agent. The present study used Bacillus tequilensis for biosynthesizing SeNPs from sodium selenite (Na 2 SeO 3 ) and investigated its ameliorative effects on acetaminophen (APAP) hepatotoxicity in male mice. The results indicated that Alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) significantly elevated in mice treated with APAP, while other liver markers (total proteins and albumin) did not change. SeNPs either alone or in combination with APAP showed ameliorative effects on liver enzymes to some extents where their activities decreased to be insignificant with those of normal group. A slight variation was shown in total antioxidant capacity (TAC). Histopathologically, the hepatocytes of the mice treated with APAP showed cloudy swelling and vacuolar degeneration, while those treated with SeNPs or both SeNPs and APAP appeared more or less histologically normal. In conclusion, SeNPs can be used to improve or replace today's therapies of APAP hepatotoxicity.

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Section: Resultssupporting

confidence: 56%

Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

AL-Harbi¹,

Amer²

2017

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“…The reduction in fructose content in seminal fluid collected from LCT intoxicated rats were drawn attention towards the secretory ability of seminal vesicles and the nutritive potential for the semen. Previous studies [42][43][44] reported that ROS were involved in the toxicity of various pesticides. ROS inhibits steroidogenesis by disrupting cholesterol transport to mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Ghosh¹,

Das²,

Paramanik³

et al. 2016

Toxicol Forensic Med Open J

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Extensive application of pesticides is usually accompanied with serious problems of pollution and health hazards. Lambda-cyhalothrin (LCT), a type II synthetic pyrethroid, is widely used in agriculture, home pest control and protection of foodstuff. This study designed to evaluate the dose dependent haematological, hepatic and gonadal toxicity of LCT at different dose levels in Wistar rat. Investigations were also done to find out the toxic effect of lambda cyhalothrin on lipid metabolism in female rat and its amelioration by taurine. Rats were exposed to different doses of lambda cyhalothrin over a period of 14 consecutive days. Exposure to LCT produced ataxia, agitation, rolling and also tremors which were considered as the signs of toxicity. Significant decrease in erythrocyte count, haemoglobin percentage, seminal fructose concentration, hepatic and testicular reduced glutathione (GSH) content was observed. Increase in leukocyte count, serum aspartic and alanine transaminase, hepatic and testicular malondialdehyde (MDA), testicular and ovarian cholesterol after LCT treatment were seen in male rats at the dose level of 10.83 mg/kg body wt. (1/7 th LD 50 ). Elevated ovarian cholesterol and MDA and reduced 3β hydroxy steroid dehydrogenase (HSD) and GSH level were also observed in lambda cyhalothrin exposed female rat at the dose level of 6.29 mg/kg body wt.(1/9 th LD 50 ). LCT caused increase in serum triglyceride, cholesterol, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and bilirubin and decrease in serum high density lipoproteins (HDL) in female rat. Taurine pretreatment ameliorated LCT induced altered lipid metabolic biomarkers in female rat.

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“…Lipid peroxidation has been suggested as one of the molecular mechanisms involved in pesticide-induced toxicity [10,11,14]. Malondialdehyde (MDA) level in LCH treatment was significantly higher than that in control.…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with its lipophilic nature [5] pyrethroid insecticide such as lambda-cyhalothrin has been found to accumulate in biologicalmembranes leading to oxidative damage. It has been suggested that some effects directly related to pesticide toxicity could be due to changes in membrane fluidity [6,7], in lipid composition [8] and inhibition of enzyme activities [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…They act as free radical scavengers and slow down not only radical oxidation but also the accompanying damaging effects in the body [13]. Previous studies [10,11,[14][15][16]reported that ROS were involved in the toxicity of various pesticides. Zinc (Zn) is an essential trace element, is relatively nontoxic and is integral to several key functions in human metabolism [17,18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Abbassy¹,

Marzouk²,

Mansour³

et al. 2014

J Environ Anal Toxicol

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Physiological and histopathological changes in the liver of male rats exposed to paracetamol and diazinon

Cited by 29 publications

References 33 publications

Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

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