Physiologic Control of Fertility

Henshaw, Paul S.

doi:10.1126/science.117.3048.572

Cited by 15 publications

(9 citation statements)

References 108 publications

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“…Jackson (319), in a review on antifertility substances, has pointed out a few alleged antifertility plants, as have Henshaw (320) and Jochle (S2l) in similar general reviews. DcLaszlo and Henshaw ( Other plants alleged to have antifertility effects in humans, and for which some (348), a fact that does not preclude the possibility of estrone contamination of the palm kernel residues during processing (348).…”

Section: Journal Of Pharmacetrtical Sciencesmentioning

confidence: 97%

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Biological and Phytochemical Screening of Plants

Farnsworth

1966

Journal of Pharmaceutical Sciences

815

436

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Section: Journal Of Pharmacetrtical Sciencesmentioning

confidence: 97%

“…Jackson (319), in a review on antifertility substances, has pointed out a few alleged antifertility plants, as have Henshaw (320) and Jochle (S2l) in similar general reviews. DcLaszlo and Henshaw (322), on the other hand, have compilcd a list of 60 antifertility plants used by primitive people.…”

Section: Journal Of Pharmacetrtical Sciencesmentioning

confidence: 99%

Biological and Phytochemical Screening of Plants

Farnsworth

1966

Journal of Pharmaceutical Sciences

815

436

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“…After Henshaw's work in 1953, there has been a steady accumulation of information regarding the screening of plants having male antifertility efficacy. The effects of these plants on such subjects were frequently evaluated measuring the hormonal profile, seminal fluid analysis and biochemical parameters (Henshaw, 1953).…”

Section: Introductionmentioning

confidence: 99%

Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

et al. 2011

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SUMMARY:Ubiquitous consumption of Momordica charantia is hinged on credence of its potency in alleviating ailments. Almost no data exist on its quantitative relationship to the testes. The aim was to study the histomorphometric effect of Momordica charantia seed extract (MC), ascorbic acid (C), alpha-tocopherol (E) and testosterone (T) on the testes of rats. Ninety five mature 6-8 week-old male Sprague-Dawley (S-D) rats allotted randomly into six groups. Group I: fed MC for 16 weeks. Group II: administered MC for 8 weeks, later distilled water for another 8 weeks. Group III: administered C, E, T and a combination of all three test solutions (CET) for 8 weeks and later fed MC for another 8 weeks. Group IV: received MC initially for 8 weeks and later administered C, E, T and CET for another 8 weeks. Group V: fed concurrently the extract, C, E, T and CET for 8 weeks. Group VI (control): administered C, E, T, CET and distilled water for 16 weeks. The doses for MC, C, E and T were 50 mg/100 g b.w/oral/day, 0.01, 20.0 and 0.05 mg/kg. The animals were sacrificed; testes estimated for volume. Diameter, cross sectional area (AC), number of profiles per unit area (NA), length density (LV) and numerical density (NV) of the seminiferous tubules determined. The mean testicular volumes, tubular diameters and AC showed significant decline (p ≤ 0.05) in Groups I and III compared to controls. On cessation of MC values recovered to baseline control value. Groups IV and V, were not significantly (p ≤ 0.05) different from controls. There was a significant (p ≤ 0.05) increase in NA, LV and NV of seminiferous tubules in Groups I and III compared to controls. Histomorphometric data supports a reversible deleterious effect of MC on testes.

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“…Although there exists an appreciable number of compounds capable of interfering with mammalian fertility (Jackson, 1964), very few, with the exception of certain steroidal compounds, have been of value in studying such problems. In spite of this inadequacy the number of new com¬ pounds added to this list since previous reviews (Henshaw, 1953;Parkes, 1953;Jackson, 1959) has been minimal.…”

Section: Introductionmentioning

confidence: 90%

The Inhibition of Pregnancy With an Oxazolidinethione (U-11634)

Duncan¹,

Johnston²,

Lyster³

1966

Reproduction

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U-11634 effectively inhibits pregnancy in rats and mice following either parenteral or oral administration. A single dose administered to rats on Day 4 was as effective as treatment for the first 7 days of pregnancy; however, a single dose on other days of pregnancy was not effective. Pregnancy could not be inhibited in hamsters. At therapeutic doses this compound did not exhibit uterotrophic, anti-oestrogenic, androgenic, gonadotrophic-inhibiting, blastolytic or foetal toxicity activities.Deciduomata formation in rats was inhibited by the compound. This effect was not reversed by progesterone or oestradiol administered simultaneously with U-11634 in ovariectomized, pseudopregnant rats with traumatized uterine horns. Inhibition of nidatory processes may be involved in the observed anti-fertility efficacy. The effects and the unique biological spectrum of this compound relative to other inhibitors of implantation are discussed.

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Physiologic Control of Fertility

Cited by 15 publications

References 108 publications

Biological and Phytochemical Screening of Plants

Biological and Phytochemical Screening of Plants

Stereological Evaluation of the Effects of Momordica charantia, antioxidants and Testosterone on Seminiferous Tubules of Rat

The Inhibition of Pregnancy With an Oxazolidinethione (U-11634)

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