Physiochemical properties of a bioceramic-based root canal sealer reinforced with multi-walled carbon nanotubes, titanium carbide and boron nitride biomaterials

Baghdadi, Inaam; Am, Zaazou; Tarboush, Belal J. Abu; Zakhour, M.; Özcan, Mutlu; Salameh, Ziad

doi:10.1016/j.jmbbm.2020.103892

Cited by 20 publications

(14 citation statements)

References 80 publications

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“…Various materials, including zinc oxide eugenol, resin, glass ionomer, and calcium hydroxide, have been utilized as root canal sealers [ 3 ]. In recent years, bioceramic-based sealers have attracted attention [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

Yan

et al. 2020

Stem Cells International

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The regeneration of bone and tooth tissues, and related cellular therapies, has attracted widespread attention. Bone marrow mesenchymal stem cells (BMSCs) are potential candidates for such regeneration. iRoot SP is a premixed bioceramic root canal sealer widely used in clinical settings. However, the effect of iRoot SP on the biological features of BMSCs has not been elucidated. In the present study, we found that 0.2 mg/ml iRoot SP conditioned medium promoted osteo/odontogenic differentiation and enhanced mineralization of BMSCs without affecting the proliferative ability. Mechanistically, the NF-κB and MAPK signaling pathways were activated in SP-treated BMSCs, and differentiation was inhibited when cultured with the specific inhibitor. Taken together, these findings demonstrate that iRoot SP promotes osteo/odontogenic differentiation of BMSCs via the NF-κB and MAPK signaling pathways, which could provide a new theoretical basis for clinical applications of iRoot SP and a new therapeutic target for the regeneration of bone and tooth tissue in the future.

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Section: Introductionmentioning

confidence: 99%

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

Yan

et al. 2020

Stem Cells International

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“…Bioactive glass (BG) which is composed of silicon oxide, calcium oxide and phosphorus pentoxide has higher bioactivity potential comparing to other bioceramic materials accounting for the amorphous structure (34) . The ions exchange between BG and body fluids could induce the formation of hydroxyapatite via biochemical reactions at the interface, forming a firm chemical bond with bones and soft tissues and stimulating tissue repair and regeneration (35) . Recently, BG has been applied in endodontics due to its biocompatibility, regenerative and antimicrobial properties.…”

Section: Discussionmentioning

confidence: 99%

An in- vitro comparative assessment of the sealing ability of AH ‎Plus sealer with different root canal nano sealers ‎

Desouky

El-Razik

Bayiumy

2022

Egyptian Dental Journal

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Objectives:The aim of the present study was to evaluate the sealing ability of experimental nano sealers (nano calcium hydroxide and nano bioactive glass) and to compare it with the commercial AH plus sealer using a dye penetration method. Materials and methods:Sixty single-rooted mandibular premolars were selected. The coronal portion of each tooth was removed to standardize root length at 16 mm and the root canals were prepared with NiTi rotary files (ProTaper Next) up to X4 (40/0.06). Teeth were randomly assigned and divided according to the sealer used for obturation into three groups of 20 each. Group I: AH plus, Group 2: Nano calcium hydroxide and Group 3: Nano-bioactive glass. All root canals were obturated using single cone gutta-percha(#40/.06) and one of the tested sealers. Root canal sealing was assessed by a dye penetration test. The data were statistically analyzed by ANOVA test followed by post hoc analysis (P < 0.05).Results: Significant improvement shown by the presented study suggests that nano calcium hydroxide sealer showed significantly less dye leakage than nano bioactive glass sealers and Ah plus sealer. Conclusion:The results of this study showed that the synthesized nano-powder sealers are suitable for use in root canal therapy to prevent leakage. The root canal can be sealed better by using smaller nano-powder particle sizes. In addition, the two groups exhibited significant differences in leakage in comparison with commonly used AH plus sealer.

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“…In order to provide more uniform HNTs, ball-milling (with zirconia bowl and balls) was used to break down the longer tubes into smaller ones. 65 To remove the unwanted materials from the interior spaces, and to make a neat structure of the ground HNTs, calcination 66 and acid-treatment processes 67 were applied, respectively. Afterward, surface-modification of the neat HNTs by a mercaptosilane compound was considered to create free thiol sites onto the surfaces for further formation of the thioester bonds with the CPP sequence.…”

Section: Preparation Of Lvx@hnt/au-cpp Nano-cargomentioning

confidence: 99%

Synergies in antimicrobial treatment by a levofloxacin-loaded halloysite and gold nanoparticles with a conjugation to a cell-penetrating peptide

et al. 2022

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Physiochemical properties of a bioceramic-based root canal sealer reinforced with multi-walled carbon nanotubes, titanium carbide and boron nitride biomaterials

Cited by 20 publications

References 80 publications

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

An in- vitro comparative assessment of the sealing ability of AH ‎Plus sealer with different root canal nano sealers ‎

Synergies in antimicrobial treatment by a levofloxacin-loaded halloysite and gold nanoparticles with a conjugation to a cell-penetrating peptide

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