Physics aspects of prostate tomotherapy: Planning optimization and image-guidance issues

Phase I–II Study of Hypofractionated Simultaneous Integrated Boost With Tomotherapy for Prostate Cancer

“…Our results are achieved through HTT thanks to the dramatic reduction in the fraction of the intestinal cavity receiving a ''high'' dose. A recent review of the planning data of a large number of patients receiving pelvic nodes irradiation with 3D-CRT or conventional IMRT or HTT confirmed the ability of HTT to dramatically reduce the fraction of IC by between 30 and 50 Gy with a significant improvement also compared with conventional five-field IMRT (29).…”

Quality assurance for image‐guided radiation therapy utilizing CT‐based technologies: A report of the AAPM TG‐179

“…Alignments are based on soft tissue targets, bony anatomy, or implanted markers, depending on the visibility of the target in fan-based MVCT images. The use of fan-beam MVCT for alignments has been reported for prostate, 115,116 lung, 117 head and neck, 118,119 breast, 120 and gynecological tumors. 121 In addition to patient alignment, fanbeam MVCT imaging has been used to document anatomical variation for various anatomical sites.…”

PET-guided dose escalation tomotherapy in malignant pleural mesothelioma

“…95% of the PTV volume received at least 95% of the prescribed dose. Normal tissue constraints from published intensity-modulated radiotherapy (IMRT) studies [1,2,21] were adopted; in addition, planning optimization was always stressed to obtain the lowest dose possible for every OAR without compromising target coverage, an approach that we usually follow during tomotherapy optimization [7,11,12].…”