Physicochemical Stereospecificity in Taste Perception of α-D-Mannose and β-D-Mannose

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

“…It is clear from Figure 5 that Stokes–Einstein diffusion cannot account for the size dependence observed, but other more restrictive diffusion schemes akin to the diffusion of solutes through polymeric matrices might be at play as has been suggested by others. 6 Additionally, increased resolvation penalties associated with departitioning from the membrane may cause membrane exit to become an additional rate limiting step. 32 …”

“…More recent models have attempted to address this discrepancy by asserting that diffusion through the ordered membrane more closely resembles the diffusion of solutes in polymers. 6 In polymer-type diffusion, the solute migrates through the medium by traversing a series of stochastically appearing holes that are of greater volume than that of the compound. Extending this principle, Xiang and Anderson proposed that there was an additional penalty associated with a lateral pressure that must be overcome during partitioning into the membrane to create a cavity of sufficient volume to accommodate the solute.…”

Mannose metabolism: More than meets the eye

“…D-Mannose is the 2-epimer of glucose and exists primarily as sweet-tasting α- (67%) or as a bitter-tasting β- (33%) anomer of the pyranose [6,7]; furanose forms comprise <2%. Mannose is ~5x as active as glucose in non-enzyamtic glycation [8], which may explain why evolution did not favor it as a biological energy source.…”

Efeitos do extrato da parede de levedura na digestibilidade, no escore fecal e na palatabilidade de dietas para gatos

“…No entanto, essa diferença é suficiente para atuar em receptores distintos, provocando sensações diferentes ao paladar. Se uma mistura estiver em equilíbrio entre essas duas estruturas, é possível que seja encontrado um efeito ambíguo (Stewart et al, 1971). …”