2010
DOI: 10.1590/s0103-50532010000600008
|View full text |Cite
|
Sign up to set email alerts
|

Physicochemical stability of poly(lactide-co-glycolide) nanocapsules containing the local anesthetic Bupivacaine

Abstract: Neste trabalho foi realizada a preparação de nanocápsulas de poli (DL-lactídeo-co-glicolídeo) (PLGA) como um sistema carreador para o anestésico local bupivacaína. A preparação foi caracterizada e sua estabilidade físico-química avaliada. Os resultados da caracterização mostram uma distribuição de tamanho com um índice de polidispersão de 0,12, um diâmetro médio de 148 nm, um potencial zeta de -43,5 mV e uma eficiência de associação da BVC nas nanocápsulas de 75,8%. As propriedades físico-químicas das suspensõ… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
16
0
1

Year Published

2012
2012
2020
2020

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 35 publications
(19 citation statements)
references
References 29 publications
2
16
0
1
Order By: Relevance
“…Size (hydrodynamic diameter), Polydispersity index (PDI) and zeta potential of particles are parameters that indicate the stability of nanoparticles (40)(41). High PDI indicates the heterogeneity of the particle size in suspension.…”
Section: Insert Figure 2 Herementioning
confidence: 99%
“…Size (hydrodynamic diameter), Polydispersity index (PDI) and zeta potential of particles are parameters that indicate the stability of nanoparticles (40)(41). High PDI indicates the heterogeneity of the particle size in suspension.…”
Section: Insert Figure 2 Herementioning
confidence: 99%
“…[94][95][96][97][98][99] The first technique consists of making a solution (oily phase) in which the polymer and the drug are dissolved in organic solvents (typically methylene chloride or chloroform). The organic solution is subsequently poured into an aqueous solution (which often contains PVA, which acts as the emulsifier) and the suspension is vortexed.…”
Section: Nanostructured Systemsmentioning
confidence: 99%
“…The solution initially, is clear and colorless then changed into cloudy solution indicated that the solution containing highly dispersed nanoparticles containing LOR-glycerin. Desirable size, zeta potential, PDI and adjusting the surface charge are parameters that indicate the colloidal stability of the obtained nanoparticles system [13][14][22][23][24].…”
Section: Resultsmentioning
confidence: 99%